Segui
Philip C Wong, Professor of Pathology
Philip C Wong, Professor of Pathology
Johns Hopkins Medicine
Email verificata su jhmi.edu
Titolo
Citata da
Citata da
Anno
Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong
Annual review of neuroscience 34, 185-204, 2011
23302011
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ...
Neuron 14 (6), 1105-1116, 1995
17461995
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong
Nature neuroscience 4 (3), 233-234, 2001
14592001
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
PC Wong, H Zheng, H Chen, MW Becher, DJS Sirinathsinghji, ...
Nature 387 (6630), 288-292, 1997
9131997
An overview of APP processing enzymes and products
VW Chow, MP Mattson, PC Wong, M Gleichmann
Neuromolecular medicine 12, 1-12, 2010
9012010
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ...
Nature medicine 9 (1), 3-4, 2003
8862003
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
BD Freibaum, Y Lu, R Lopez-Gonzalez, NC Kim, S Almeida, KH Lee, ...
Nature 525 (7567), 129-133, 2015
8462015
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ...
Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994
7881994
Bace1 modulates myelination in the central and peripheral nervous system
X Hu, CW Hicks, W He, P Wong, WB Macklin, BD Trapp, R Yan
Nature neuroscience 9 (12), 1520-1525, 2006
7572006
The β-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential
R Vassar, DM Kovacs, R Yan, PC Wong
Journal of neuroscience 29 (41), 12787-12794, 2009
6982009
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ...
Journal of Neuroscience 25 (50), 11693-11709, 2005
6762005
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ...
Proceedings of the National Academy of Sciences 101 (10), 3632-3637, 2004
6512004
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
J Liu, C Lillo, PA Jonsson, CV Velde, CM Ward, TM Miller, ...
Neuron 43 (1), 5-17, 2004
6362004
Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues
M Watanabe, M Dykes-Hoberg, VC Culotta, DL Price, PC Wong, ...
Neurobiology of disease 8 (6), 933-941, 2001
5322001
Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes
KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ...
Journal of Biological Chemistry 279 (43), 44945-44954, 2004
5282004
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
JP Ling, O Pletnikova, JC Troncoso, PC Wong
Science 349 (6248), 650-655, 2015
4892015
Effects of PS1 deficiency on membrane protein trafficking in neurons
S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ...
Neuron 21 (5), 1213-1221, 1998
4761998
Neurofilaments are obligate heteropolymers in vivo
MK Lee, Z Xu, PC Wong, DW Cleveland
The Journal of cell biology 122 (6), 1337-1350, 1993
4731993
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
S Rabizadeh, EB Gralla, DR Borchelt, R Gwinn, JS Valentine, S Sisodia, ...
Proceedings of the National Academy of Sciences 92 (7), 3024-3028, 1995
4331995
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
R Vassar, PH Kuhn, C Haass, ME Kennedy, L Rajendran, PC Wong, ...
Journal of neurochemistry 130 (1), 4-28, 2014
4022014
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
Articoli 1–20