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Matt Hepworth
Matt Hepworth
Verified email at manchester.ac.uk - Homepage
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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
MR Hepworth, LA Monticelli, TC Fung, CGK Ziegler, S Grunberg, R Sinha, ...
Nature 498 (7452), 113-117, 2013
8422013
TSLP elicits IL-33–independent innate lymphoid cell responses to promote skin inflammation
BS Kim, MC Siracusa, SA Saenz, M Noti, LA Monticelli, GF Sonnenberg, ...
Science translational medicine 5 (170), 170ra16-170ra16, 2013
7752013
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells
MR Hepworth, TC Fung, SH Masur, JR Kelsen, FM McConnell, J Dubrot, ...
Science 348 (6238), 1031-1035, 2015
5212015
IL-33, a potent inducer of adaptive immunity to intestinal nematodes
NE Humphreys, D Xu, MR Hepworth, FY Liew, RK Grencis
The Journal of Immunology 180 (4), 2443-2449, 2008
5042008
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
LC Osborne, LA Monticelli, TJ Nice, TE Sutherland, MC Siracusa, ...
Science 345 (6196), 578-582, 2014
2742014
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
LA Monticelli, MD Buck, AL Flamar, SA Saenz, ED Tait Wojno, ...
Nature immunology 17 (6), 656-665, 2016
2532016
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells
DR Withers, MR Hepworth, X Wang, EC Mackley, EE Halford, EE Dutton, ...
Nature medicine 22 (3), 319-323, 2016
2342016
Functional interactions between innate lymphoid cells and adaptive immunity
GF Sonnenberg, MR Hepworth
Nature Reviews Immunology 19 (10), 599-613, 2019
2172019
CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
EC Mackley, S Houston, CL Marriott, EE Halford, B Lucas, V Cerovic, ...
Nature communications 6 (1), 5862, 2015
2092015
Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines
MR Hepworth, E Daniłowicz-Luebert, S Rausch, M Metz, C Klotz, ...
Proceedings of the National Academy of Sciences 109 (17), 6644-6649, 2012
2002012
Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
F Melo‐Gonzalez, MR Hepworth
Immunology 150 (3), 265-275, 2017
1892017
Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation
J Emgård, H Kammoun, B García-Cassani, J Chesné, SM Parigi, ...
Immunity 48 (1), 120-132. e8, 2018
1702018
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages
C Klotz, T Ziegler, AS Figueiredo, S Rausch, MR Hepworth, N Obsivac, ...
PLoS pathogens 7 (1), e1001248, 2011
1632011
Lymphoid-tissue-resident commensal bacteria promote members of the IL-10 cytokine family to establish mutualism
TC Fung, NJ Bessman, MR Hepworth, N Kumar, N Shibata, D Kobuley, ...
Immunity 44 (3), 634-646, 2016
1542016
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria
F Melo-Gonzalez, H Kammoun, E Evren, EE Dutton, M Papadopoulou, ...
Journal of Experimental Medicine 216 (4), 728-742, 2019
1302019
A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation
T Ziegler, S Rausch, S Steinfelder, C Klotz, MR Hepworth, AA Kühl, ...
The Journal of Immunology 194 (4), 1555-1564, 2015
1042015
The role of sex hormones in the development of Th2 immunity in a gender‐biased model of Trichuris muris infection
MR Hepworth, MJ Hardman, RK Grencis
European journal of immunology 40 (2), 406-416, 2010
1032010
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells
S Rausch, J Huehn, C Loddenkemper, MR Hepworth, C Klotz, ...
European journal of immunology 39 (11), 3066-3077, 2009
922009
Group 3 innate lymphoid cells: communications hubs of the intestinal immune system
DR Withers, MR Hepworth
Frontiers in immunology 8, 300799, 2017
912017
IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology
J Stange, MR Hepworth, S Rausch, L Zajic, AA Kühl, C Uyttenhove, ...
The Journal of Immunology 188 (5), 2410-2418, 2012
772012
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