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Iain McFadyen
Iain McFadyen
Tessera Therapeutics
Email verificata su tesseratx.com
Titolo
Citata da
Citata da
Anno
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
KJ Hassett, KE Benenato, E Jacquinet, A Lee, A Woods, O Yuzhakov, ...
Molecular Therapy-Nucleic Acids 15, 1-11, 2019
5642019
A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates
KEB Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai ...
Molecular Therapy, 2018
4962018
mRNA structure regulates protein expression through changes in functional half-life
DM Mauger, BJ Cabral, V Presnyak, SV Su, DW Reid, B Goodman, K Link, ...
Proceedings of the National Academy of Sciences 116 (48), 24075-24083, 2019
3422019
Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
PJ Sample, B Wang, DW Reid, V Presnyak, IJ McFadyen, DR Morris, ...
Nature Biotechnology 37 (7), 803, 2019
2442019
A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino) dibenzo [b …
W Li, J Li, Y Wu, J Wu, R Hotchandani, K Cunningham, I McFadyen, ...
Journal of medicinal chemistry 52 (7), 1799-1802, 2009
1102009
Application of a high‐throughput screening procedure with PEG‐induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal …
TJ Gibson, K Mccarty, IJ McFadyen, E Cash, P Dalmonte, KD Hinds, ...
Journal of pharmaceutical sciences 100 (3), 1009-1021, 2011
1032011
Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio)
RE Rodriguez, A Barrallo, F Garcia-Malvar, IJ McFadyen, ...
Neuroscience letters 288 (3), 207-210, 2000
652000
Towards ambient temperature-stable vaccines: The identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay
LD Schlehuber, IJ McFadyen, Y Shu, J Carignan, WP Duprex, WR Forsyth, ...
Vaccine 29 (31), 5031-5039, 2011
592011
Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease
P Martini, SG Hoge, K Benenato, V Presnyak, I McFadyen, ...
US Patent 10,519,455, 2019
562019
Polynucleotides encoding citrin for the treatment of Citrullinemia type 2
P Martini, S Hoge, K Benenato, V Presnyak, I McFadyen, ...
US Patent 10,993,918, 2021
512021
Polynucleotides encoding jagged1 for the treatment of alagille syndrome
K Benenato, S Hoge, P Martini, I McFadyen, V Presnyak, D An, ...
US Patent App. 16/302,607, 2019
512019
Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models
C Wang, IJ McFadyen, JR Traynor, HI Mosberg
Bioorganic & medicinal chemistry letters 8 (19), 2685-2688, 1998
481998
MRNA combination therapy for the treatment of cancer
JP Frederick, S Hewitt, A Bai, SG Hoge, V Presnyak, I McFadyen, ...
US Patent 10,335,486, 2019
462019
Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors
AM Gilbert, M Kirisits, P Toy, DS Nunn, A Failli, EG Dushin, E Novikova, ...
Bioorganic & medicinal chemistry letters 14 (1), 37-41, 2004
442004
Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
P Martini, S Hoge, K Benenato, V Presnyak, L Jiang, I McFadyen, ...
US Patent App. 16/302,339, 2020
422020
POLYNUCLEOTIDE SECONDARY STRUCTURE
D Mauger, I Mcfadyen, V Presnyak
US Patent App. 16/483,012, 2020
412020
Polynucleotides Encoding Lipoprotein Lipase for the Treatment of Hyperlipidemia
K Benenato, S Hoge, P Martini, I McFadyen, V Presnyak, ...
US Patent App. 16/302,368, 2019
412019
Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
P Martini, S Hoge, K Benenato, V Presnyak, I McFadyen, ...
US Patent App. 16/302,298, 2019
412019
A sensitivity analysis of RNA folding nearest neighbor parameters identifies a subset of free energy parameters with the greatest impact on RNA secondary structure prediction.
J Zuber, H Sun, X Zhang, I McFadyen, D Mathews
Nucleic Acids Research, 2017
402017
Polynucleotides encoding relaxin
B Ticho, N Briancon-Eris, Z Xia, A Dousis, S De Picciotto, V Presnyak, ...
US Patent 10,730,924, 2020
392020
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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