| A novel human protease similar to the interleukin‐1 beta converting enzyme induces apoptosis in transfected cells. C Faucheu, A Diu, AW Chan, AM Blanchet, C Miossec, F Herve, ... The EMBO Journal 14 (9), 1914-1922, 1995 | 421 | 1995 |
| Genomic-scale prioritization of drug targets: the TDR Targets database F Agüero, B Al-Lazikani, M Aslett, M Berriman, FS Buckner, RK Campbell, ... Nature reviews Drug discovery 7 (11), 900-907, 2008 | 357 | 2008 |
| Two‐and three‐dimensional rings in drugs M Aldeghi, S Malhotra, DL Selwood, AWE Chan Chemical biology & drug design 83 (4), 450-461, 2014 | 288 | 2014 |
| Tri-tert-butylsilyl) imido complexes of titanium: benzene carbon-hydrogen activation and structure of [(tert-Bu3SiNH) Ti] 2 (. mu.-NSi-tert-Bu3) 2 CC Cummins, CP Schaller, GD Van Duyne, PT Wolczanski, AWE Chan, ... Journal of the American Chemical Society 113 (8), 2985-2994, 1991 | 250 | 1991 |
| Identification, classification, and analysis of beta‐bulges in proteins AWE Chan, EG Hutchinson, D Harris, JM Thornton Protein Science 2 (10), 1574-1590, 1993 | 237 | 1993 |
| Synthesis, Structure−Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- N-[3 … EA Kuo, PT Hambleton, DP Kay, PL Evans, SS Matharu, E Little, ... Journal of medicinal chemistry 39 (23), 4608-4621, 1996 | 113 | 1996 |
| Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis J Warne, G Pryce, JM Hill, X Shi, F Lennerås, F Puentes, M Kip, L Hilditch, ... Journal of Biological Chemistry 291 (9), 4356-4373, 2016 | 95 | 2016 |
| Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis J Warne, G Pryce, JM Hill, X Shi, F Lennerås, F Puentes, M Kip, L Hilditch, ... Journal of Biological Chemistry 291 (9), 4356-4373, 2016 | 95 | 2016 |
| Small molecule neuropilin-1 antagonists combine antiangiogenic and antitumor activity with immune modulation through reduction of transforming growth factor beta (TGFβ … J Powell, F Mota, D Steadman, C Soudy, JT Miyauchi, S Crosby, A Jarvis, ... Journal of medicinal chemistry 61 (9), 4135-4154, 2018 | 72 | 2018 |
| Theoretical aspects of photoinitiated chemisorption, dissociation, and desorption of oxygen on platinum (111) AWE Chan, R Hoffmann, W Ho Langmuir 8 (4), 1111-1119, 1992 | 66 | 1992 |
| Covalent Aurora A regulation by the metabolic integrator coenzyme A Y Tsuchiya, DP Byrne, SG Burgess, J Bormann, J Baković, Y Huang, ... Redox biology 28, 101318, 2020 | 52 | 2020 |
| Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization AWH Lo, K Van de Water, PJ Gane, AWE Chan, D Steadman, K Stevens, ... Journal of antimicrobial chemotherapy 69 (4), 1017-1026, 2014 | 52 | 2014 |
| PDBLIG: classification of small molecular protein binding in the Protein Data Bank AJ Chalk, CL Worth, JP Overington, AWE Chan Journal of medicinal chemistry 47 (15), 3807-3816, 2004 | 51 | 2004 |
| Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis S Al-Izki, G Pryce, DJR Hankey, K Lidster, SM von Kutzleben, L Browne, ... Brain 137 (1), 92-108, 2014 | 50 | 2014 |
| Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites AWE Chan, RA Laskowski, DL Selwood Journal of medicinal chemistry 53 (8), 3086-3094, 2010 | 44 | 2010 |
| PF3, PF2, and PF on Ni(111): Theoretical aspects of their chemisorption AWE Chan, R Hoffmann The Journal of chemical physics 92 (1), 699-708, 1990 | 37 | 1990 |
| Prediction of relative potency of ketone protease inhibitors using molecular orbital theory AWE Chan, JMC Golec Bioorganic & medicinal chemistry 4 (10), 1673-1677, 1996 | 28 | 1996 |
| Architecture and hydration of the arginine‐binding site of neuropilin‐1 F Mota, C Fotinou, RR Rana, AWE Chan, T Yelland, MT Arooz, ... The FEBS journal 285 (7), 1290-1304, 2018 | 27 | 2018 |
| N‐terminal modification of VEGF‐AC terminus‐derived peptides delineates structural features involved in neuropilin‐1 binding and functional activity H Jia, R Aqil, L Cheng, C Chapman, S Shaikh, A Jarvis, AWE Chan, ... ChemBioChem 15 (8), 1161-1170, 2014 | 27 | 2014 |
| A small-molecule PI3Kα activator for cardioprotection and neuroregeneration GQ Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, ... Nature 618 (7963), 159-168, 2023 | 25 | 2023 |
