James Cantley
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G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, ...
Diabetologia 55 (10), 2682-2692, 2012
Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice
J Cantley, C Selman, D Shukla, AY Abramov, F Forstreuter, MA Esteban, ...
The Journal of clinical investigation 119 (1), 125-135, 2009
The hypoxia response pathway and β‐cell function
J Cantley, ST Grey, PH Maxwell, DJ Withers
Diabetes, Obesity and Metabolism 12, 159-167, 2010
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
J Cantley, AI Choudhury, H Asare-Anane, C Selman, S Lingard, H Heffron, ...
Diabetologia 50 (6), 1248-1256, 2007
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
J Cantley, FM Ashcroft
BMC biology 13 (1), 1-7, 2015
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells
E Boslem, JM Weir, G MacIntosh, N Sue, J Cantley, PJ Meikle, TJ Biden
Journal of Biological Chemistry 288 (37), 26569-26582, 2013
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity
LE Wu, D Samocha-Bonet, PT Whitworth, DJ Fazakerley, N Turner, ...
Molecular metabolism 3 (4), 465-473, 2014
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis
J Cantley
Mammalian Genome 25 (9), 442-454, 2014
Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice
XY Zeng, YP Wang, J Cantley, TJ Iseli, JC Molero, BD Hegarty, ...
PLoS One 7 (7), e42115, 2012
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
K Raddatz, N Turner, G Frangioudakis, BM Liao, DJ Pedersen, J Cantley, ...
Diabetologia 54 (6), 1447-1456, 2011
Deletion of PKCε selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse β-cells
J Cantley, JG Burchfield, GL Pearson, C Schmitz-Peiffer, M Leitges, ...
Diabetes 58 (8), 1826-1834, 2009
Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice
M Simmgen, C Knauf, M Lopez, AI Choudhury, M Charalambous, ...
Diabetologia 49 (3), 552-561, 2006
A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis
J Cantley, SN Walters, MH Jung, A Weinberg, MJ Cowley, PT Whitworth, ...
Cell transplantation 22 (11), 2147-2159, 2013
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells
GL Pearson, N Mellett, KY Chu, J Cantley, A Davenport, P Bourbon, ...
Diabetologia 57 (1), 129-139, 2014
Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
EK Malle, NW Zammit, SN Walters, YC Koay, J Wu, BM Tan, ...
Journal of Experimental Medicine 212 (8), 1239-1254, 2015
The diverse roles of protein kinase C in pancreatic β-cell function
TJ Biden, C Schmitz-Peiffer, JG Burchfield, E Gurisik, J Cantley, ...
Biochemical Society Transactions 36 (5), 916-919, 2008
High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice
JG Burchfield, MA Kebede, CC Meoli, J Stöckli, PT Whitworth, AL Wright, ...
Journal of biological chemistry 293 (15), 5731-5745, 2018
DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake
J Li, J Cantley, JG Burchfield, CC Meoli, J Stöckli, PT Whitworth, H Pant, ...
Diabetologia 57 (10), 2173-2182, 2014
Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in female mice
YC Shi, K Loh, M Bensellam, K Lee, L Zhai, J Lau, J Cantley, J Luzuriaga, ...
Endocrinology 156 (9), 3122-3136, 2015
Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo
J Cantley, E Boslem, DR Laybutt, DV Cordery, G Pearson, L Carpenter, ...
Diabetologia 54 (2), 380-389, 2011
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