Jean Piero Margaria
Jean Piero Margaria
Universitą di Torino, Molecular Biotechnology Center
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PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
I Franco, F Gulluni, CC Campa, C Costa, JP Margaria, E Ciraolo, ...
Developmental cell 28 (6), 647-658, 2014
Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth
M Li, V Sala, MC De Santis, J Cimino, P Cappello, N Pianca, A Di Bona, ...
Circulation 138 (7), 696-711, 2018
Class II PI3K functions in cell biology and disease
F Gulluni, MC De Santis, JP Margaria, M Martini, E Hirsch
Trends in cell biology 29 (4), 339-359, 2019
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes
CC Campa, JP Margaria, A Derle, M Del Giudice, MC De Santis, ...
Nature chemical biology 14 (8), 801-810, 2018
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, ...
Nature communications 9 (1), 5232, 2018
Mitotic spindle assembly and genomic stability in breast cancer require PI3K-C2α scaffolding function
F Gulluni, M Martini, MC De Santis, CC Campa, A Ghigo, JP Margaria, ...
Cancer Cell 32 (4), 444-459. e7, 2017
The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium
JP Margaria, CC Campa, MC De Santis, E Hirsch, I Franco
Cellular signalling 66, 109468, 2020
Phosphoinositide 3-kinase-C2α regulates polycystin-2 ciliary entry and protects against kidney cyst formation
I Franco, JP Margaria, MC De Santis, A Ranghino, D Monteyne, ...
Journal of the American Society of Nephrology: JASN 27 (4), 1135, 2016
Class II PI3Ks at the intersection between signal transduction and membrane trafficking
JP Margaria, E Ratto, L Gozzelino, H Li, E Hirsch
Biomolecules 9 (3), 104, 2019
Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure
S Karam, JP Margaria, A Bourcier, D Mika, A Varin, I Bedioune, M Lindner, ...
Circulation 142 (2), 161-174, 2020
A novel multiplex qRT-PCR assay to detect SARS-CoV-2 infection: high sensitivity and increased testing capacity
S Petrillo, G Carrą, P Bottino, E Zanotto, MC De Santis, JP Margaria, ...
Microorganisms 8 (7), 1064, 2020
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
ML Jenkins, JP Margaria, JTB Stariha, RM Hoffmann, JA McPhail, ...
Nature Communications 9 (1), 3772, 2018
PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation
F Gulluni, L Prever, H Li, P Krafcikova, I Corrado, WT Lo, JP Margaria, ...
Science 374 (6573), eabk0410, 2021
PI3K signaling in mechanisms and treatments of pulmonary fibrosis following sepsis and acute lung injury
JP Margaria, L Moretta, JC Alves-Filho, E Hirsch
Biomedicines 10 (4), 756, 2022
Identification of a potent phosphoinositide 3‐kinase pan inhibitor displaying a strategic carboxylic acid group and development of its prodrugs
T Pirali, E Ciraolo, S Aprile, A Massarotti, A Berndt, A Griglio, M Serafini, ...
ChemMedChem 12 (18), 1542-1554, 2017
Phosphoinositide conversion inactivates R‐RAS and drives metastases in breast cancer
H Li, L Prever, MY Hsu, WT Lo, JP Margaria, MC De Santis, C Zanini, ...
Advanced Science 9 (9), 2103249, 2022
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
MC De Santis, L Gozzelino, JP Margaria, A Costamagna, E Ratto, ...
Gut 72 (2), 360-371, 2023
Therapeutic targeting of PDEs and PI3K in heart failure with preserved ejection fraction (HFpEF)
V Sala, JP Margaria, A Murabito, F Morello, A Ghigo, E Hirsch
Current heart failure reports 14, 187-196, 2017
The guareschi pyridine scaffold as a valuable platform for the identification of selective PI3K inhibitors
U Galli, E Ciraolo, A Massarotti, JP Margaria, G Sorba, E Hirsch, GC Tron
Molecules 20 (9), 17275-17287, 2015
A novel multiplex qRT-PCR assay to detect SARS-CoV-2 infection: high sensitivity and increased testing capacity. Microorganisms [Internet]. 2020
S Petrillo, G Carrą, P Bottino, E Zanotto, MC De Santis, JP Margaria, ...
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