| PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function I Franco, F Gulluni, CC Campa, C Costa, JP Margaria, E Ciraolo, ... Developmental cell 28 (6), 647-658, 2014 | 203 | 2014 |
| Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth M Li, V Sala, MC De Santis, J Cimino, P Cappello, N Pianca, A Di Bona, ... Circulation 138 (7), 696-711, 2018 | 163 | 2018 |
| Class II PI3K functions in cell biology and disease F Gulluni, MC De Santis, JP Margaria, M Martini, E Hirsch Trends in cell biology 29 (4), 339-359, 2019 | 120 | 2019 |
| Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes CC Campa, JP Margaria, A Derle, M Del Giudice, MC De Santis, ... Nature chemical biology 14 (8), 801-810, 2018 | 96 | 2018 |
| Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, ... Nature communications 9 (1), 5232, 2018 | 86 | 2018 |
| Mitotic spindle assembly and genomic stability in breast cancer require PI3K-C2α scaffolding function F Gulluni, M Martini, MC De Santis, CC Campa, A Ghigo, JP Margaria, ... Cancer Cell 32 (4), 444-459. e7, 2017 | 77 | 2017 |
| The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium JP Margaria, CC Campa, MC De Santis, E Hirsch, I Franco Cellular signalling 66, 109468, 2020 | 58 | 2020 |
| Phosphoinositide 3-kinase-C2α regulates polycystin-2 ciliary entry and protects against kidney cyst formation I Franco, JP Margaria, MC De Santis, A Ranghino, D Monteyne, ... Journal of the American Society of Nephrology 27 (4), 1135-1144, 2016 | 55 | 2016 |
| Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure S Karam, JP Margaria, A Bourcier, D Mika, A Varin, I Bedioune, M Lindner, ... Circulation 142 (2), 161-174, 2020 | 50 | 2020 |
| Class II PI3Ks at the intersection between signal transduction and membrane trafficking JP Margaria, E Ratto, L Gozzelino, H Li, E Hirsch Biomolecules 9 (3), 104, 2019 | 50 | 2019 |
| A novel multiplex qRT-PCR assay to detect SARS-CoV-2 infection: high sensitivity and increased testing capacity S Petrillo, G Carrà, P Bottino, E Zanotto, MC De Santis, JP Margaria, ... Microorganisms 8 (7), 1064, 2020 | 42 | 2020 |
| Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 ML Jenkins, JP Margaria, JTB Stariha, RM Hoffmann, JA McPhail, ... Nature Communications 9 (1), 3772, 2018 | 38 | 2018 |
| PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation F Gulluni, L Prever, H Li, P Krafcikova, I Corrado, WT Lo, JP Margaria, ... Science 374 (6573), eabk0410, 2021 | 34 | 2021 |
| PI3K signaling in mechanisms and treatments of pulmonary fibrosis following sepsis and acute lung injury JP Margaria, L Moretta, JC Alves-Filho, E Hirsch Biomedicines 10 (4), 756, 2022 | 25 | 2022 |
| Identification of a potent phosphoinositide 3‐kinase pan inhibitor displaying a strategic carboxylic acid group and development of its prodrugs T Pirali, E Ciraolo, S Aprile, A Massarotti, A Berndt, A Griglio, M Serafini, ... ChemMedChem 12 (18), 1542-1554, 2017 | 22 | 2017 |
| Phosphoinositide conversion inactivates R‐RAS and drives metastases in breast cancer H Li, L Prever, MY Hsu, WT Lo, JP Margaria, MC De Santis, C Zanini, ... Advanced Science 9 (9), 2103249, 2022 | 12 | 2022 |
| Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer MC De Santis, L Gozzelino, JP Margaria, A Costamagna, E Ratto, ... Gut 72 (2), 360-371, 2023 | 10 | 2023 |
| Therapeutic targeting of PDEs and PI3K in heart failure with preserved ejection fraction (HFpEF) V Sala, JP Margaria, A Murabito, F Morello, A Ghigo, E Hirsch Current heart failure reports 14, 187-196, 2017 | 8 | 2017 |
| The guareschi pyridine scaffold as a valuable platform for the identification of selective PI3K inhibitors U Galli, E Ciraolo, A Massarotti, JP Margaria, G Sorba, E Hirsch, GC Tron Molecules 20 (9), 17275-17287, 2015 | 7 | 2015 |
| A novel multiplex qRT-PCR assay to detect SARS-CoV-2 infection: high sensitivity and increased testing capacity. Microorganisms [Internet]. 2020 S Petrillo, G Carrà, P Bottino, E Zanotto, MC De Santis, JP Margaria | 4 | 2021 |
