Giorgio Colombo
Giorgio Colombo
Professor of Organic Chemistry, University of Pavia; Head of Biocomputing Group, SCITEC-CNR Milan
Email verificata su unipv.it - Home page
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Mechanism by which 2, 2, 2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: a molecular dynamics study
D Roccatano, G Colombo, M Fioroni, AE Mark
Proceedings of the National Academy of Sciences 99 (19), 12179-12184, 2002
5152002
Rational design of shepherdin, a novel anticancer agent
J Plescia, W Salz, F Xia, M Pennati, N Zaffaroni, MG Daidone, M Meli, ...
Cancer cell 7 (5), 457-468, 2005
3782005
Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif
G Colombo, F Curnis, GMS De Mori, A Gasparri, C Longoni, A Sacchi, ...
Journal of Biological Chemistry 277 (49), 47891-47897, 2002
2292002
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
BH Kang, J Plescia, HY Song, M Meli, G Colombo, K Beebe, B Scroggins, ...
The Journal of clinical investigation 119 (3), 454-464, 2009
1982009
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
M Mollapour, S Tsutsumi, AC Donnelly, K Beebe, MJ Tokita, MJ Lee, ...
Molecular cell 37 (3), 333-343, 2010
1642010
Peptide self-assembly at the nanoscale: a challenging target for computational and experimental biotechnology
G Colombo, P Soto, E Gazit
TRENDS in Biotechnology 25 (5), 211-218, 2007
1572007
Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer
G Morra, G Verkhivker, G Colombo
PLoS Comput Biol 5 (3), e1000323, 2009
1462009
Solvent dynamics and mechanism of proton transfer in human carbonic anhydrase II
S Toba, G Colombo, KM Merz
Journal of the American Chemical Society 121 (10), 2290-2302, 1999
1241999
β‐Hairpin conformation of fibrillogenic peptides: Structure and α‐β transition mechanism revealed by molecular dynamics simulations
I Daidone, F Simona, D Roccatano, RA Broglia, G Tiana, G Colombo, ...
Proteins: Structure, Function, and Bioinformatics 57 (1), 198-204, 2004
1132004
Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead
M Meli, M Pennati, M Curto, MG Daidone, J Plescia, S Toba, DC Altieri, ...
Journal of medicinal chemistry 49 (26), 7721-7730, 2006
1052006
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors
B Gyurkocza, J Plescia, CM Raskett, DS Garlick, PA Lowry, BZ Carter, ...
Journal of the National Cancer Institute 98 (15), 1068-1077, 2006
1052006
Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis (oxazoline)-Cu (II) complexes
A Bernardi, G Colombo, C Scolastico
Tetrahedron letters 37 (49), 8921-8924, 1996
1031996
Sequence dependence of amyloid fibril formation: insights from molecular dynamics simulations
ML de la Paz, GMS de Mori, L Serrano, G Colombo
Journal of molecular biology 349 (3), 583-596, 2005
942005
Effect of hexafluoroisopropanol alcohol on the structure of melittin: A molecular dynamics simulation study
D Roccatano, M Fioroni, M Zacharias, G Colombo
Protein Science 14 (10), 2582-2589, 2005
882005
Simulation of MscL gating in a bilayer under stress
G Colombo, SJ Marrink, AE Mark
Biophysical journal 84 (4), 2331-2337, 2003
882003
Corresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulations
G Morra, R Potestio, C Micheletti, G Colombo
PLoS Comput Biol 8 (3), e1002433, 2012
872012
Pharmacological enhancement of α-glucosidase by the allosteric chaperone N-acetylcysteine
C Porto, MC Ferrara, M Meli, E Acampora, V Avolio, M Rosa, ...
Molecular Therapy 20 (12), 2201-2211, 2012
832012
Understanding the determinants of stability and folding of small globular proteins from their energetics
G Tiana, F Simona, GMS De Mori, RA Broglia, G Colombo
Protein Science 13 (1), 113-124, 2004
812004
Stability and activity of mesophilic subtilisin E and its thermophilic homolog: insights from molecular dynamics simulations
G Colombo, KM Merz
Journal of the American Chemical Society 121 (29), 6895-6903, 1999
781999
A multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35
J Nasica-Labouze, M Meli, P Derreumaux, G Colombo, N Mousseau
PLoS Comput Biol 7 (5), e1002051, 2011
772011
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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