Bryan Briney
Bryan Briney
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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
TF Rogers, F Zhao, D Huang, N Beutler, A Burns, WT He, O Limbo, ...
Science 369 (6506), 956-963, 2020
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
JG Jardine, T Ota, D Sok, M Pauthner, DW Kulp, O Kalyuzhniy, PD Skog, ...
Science 349 (6244), 156-161, 2015
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
JG Jardine, DW Kulp, C Havenar-Daughton, A Sarkar, B Briney, D Sok, ...
Science 351 (6280), 1458-1463, 2016
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
D Sok, MJ van Gils, M Pauthner, JP Julien, KL Saye-Francisco, J Hsueh, ...
Proceedings of the National Academy of Sciences 111 (49), 17624-17629, 2014
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
JM Steichen, DW Kulp, T Tokatlian, A Escolano, P Dosenovic, ...
Immunity 45 (3), 483-496, 2016
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
D Sok, U Laserson, J Laserson, Y Liu, F Vigneault, JP Julien, B Briney, ...
PLoS pathogens 9 (11), e1003754, 2013
Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
B Briney, D Sok, JG Jardine, DW Kulp, P Skog, S Menis, R Jacak, ...
Cell 166 (6), 1459-1470. e11, 2016
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV
D Sok, KJ Doores, B Briney, KM Le, KL Saye-Francisco, A Ramos, ...
Science translational medicine 6 (236), 236ra63-236ra63, 2014
Commonality despite exceptional diversity in the baseline human antibody repertoire
B Briney, A Inderbitzin, C Joyce, DR Burton
Nature 566 (7744), 393-397, 2019
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
LE McCoy, MJ van Gils, G Ozorowski, T Messmer, B Briney, JE Voss, ...
Cell reports 16 (9), 2327-2338, 2016
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes
BS Briney, JR Willis, JE Crowe Jr
PloS one 7 (5), e36750, 2012
Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design
R Andrabi, JE Voss, CH Liang, B Briney, LE McCoy, CY Wu, CH Wong, ...
Immunity 43 (5), 959-973, 2015
Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer
C Havenar-Daughton, DG Carnathan, AT de la Peņa, M Pauthner, ...
Cell reports 17 (9), 2195-2209, 2016
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
D Sok, B Briney, JG Jardine, DW Kulp, S Menis, M Pauthner, A Wood, ...
Science 353 (6307), 1557-1560, 2016
Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch
DT MacLeod, NM Choi, B Briney, F Garces, LS Ver, E Landais, B Murrell, ...
Immunity 44 (5), 1215-1226, 2016
A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans
D Sok, M Pauthner, B Briney, JH Lee, KL Saye-Francisco, J Hsueh, ...
Immunity 45 (1), 31-45, 2016
Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence
JC Krause, T Tsibane, TM Tumpey, CJ Huffman, BS Briney, SA Smith, ...
The Journal of Immunology 187 (7), 3704-3711, 2011
Human germline antibody gene segments encode polyspecific antibodies
JR Willis, BS Briney, SL DeLuca, JE Crowe Jr, J Meiler
PLoS computational biology 9 (4), e1003045, 2013
Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design
JG Jardine, D Sok, JP Julien, B Briney, A Sarkar, CH Liang, EA Scherer, ...
PLoS pathogens 12 (8), e1005815, 2016
High-throughput antibody sequencing reveals genetic evidence of global regulation of the naive and memory repertoires that extends across individuals
BS Briney, JR Willis, BA McKinney, JE Crowe
Genes & Immunity 13 (6), 469-473, 2012
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