| Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility PE Tomatis, SM Fabiane, F Simona, P Carloni, BJ Sutton, AJ Vila Proceedings of the National Academy of Sciences 105 (52), 20605-20610, 2008 | 120 | 2008 |
| Mimicking natural evolution in metallo-β-lactamases through second-shell ligand mutations PE Tomatis, RM Rasia, L Segovia, AJ Vila Proceedings of the National Academy of Sciences 102 (39), 13761-13766, 2005 | 111 | 2005 |
| Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions JM González, MR Meini, PE Tomatis, FJM Martín, JA Cricco, AJ Vila Nature chemical biology 8 (8), 698-700, 2012 | 70 | 2012 |
| Quantitative description of a protein fitness landscape based on molecular features MR Meini, PE Tomatis, DM Weinreich, AJ Vila Molecular biology and evolution 32 (7), 1774-1787, 2015 | 64 | 2015 |
| Optimization of conformational dynamics in an epistatic evolutionary trajectory MM González, LA Abriata, PE Tomatis, AJ Vila Molecular Biology and Evolution 33 (7), 1768-1776, 2016 | 55 | 2016 |
| A minimalistic approach to identify substrate binding features in B1 metallo-β-lactamases AA Poeylaut-Palena, PE Tomatis, AI Karsisiotis, C Damblon, EG Mata, ... Bioorganic & medicinal chemistry letters 17 (18), 5171-5174, 2007 | 44 | 2007 |
| Biochemical Characterization of Metallo-β-Lactamase VIM-11 from a Pseudomonas aeruginosa Clinical Strain P Marchiaro, PE Tomatis, MA Mussi, F Pasteran, AM Viale, AS Limansky, ... Antimicrobial agents and chemotherapy 52 (6), 2250-2252, 2008 | 40 | 2008 |
| Sequence–function–stability relationships in proteins from datasets of functionally annotated variants: The case of TEM β-lactamases LA Abriata, MLM Salverda, PE Tomatis FEBS letters 586 (19), 3330-3335, 2012 | 32 | 2012 |
| Engineered Mononuclear Variants in Bacillus cereus Metallo-β-lactamase BcII Are Inactive LA Abriata, LJ González, LI Llarrull, PE Tomatis, WK Myers, AL Costello, ... Biochemistry 47 (33), 8590-8599, 2008 | 32 | 2008 |
| Analysis of Mesorhizobium loti glycogen operon: effect of phosphoglucomutase (pgm) and glycogen synthase (glgA) null mutants on nodulation of Lotus tenuis VC Lepek, AL D'Antuono, PE Tomatis, JE Ugalde, S Giambiagi, ... Molecular plant-microbe interactions 15 (4), 368-375, 2002 | 26 | 2002 |
| Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli PE Tomatis, M Schütz, E Umudumov, A Plückthun Scientific reports 9 (1), 2483, 2019 | 9 | 2019 |
| Longitudinal evolution of the Pseudomonas-derived cephalosporinase (PDC) structure and activity in a cystic fibrosis patient treated with β-lactams CA Colque, AG Albarracin Orio, PE Tomatis, G Dotta, DM Moreno, ... Mbio 13 (5), e01663-22, 2022 | 6 | 2022 |
| The biochemistry and enzymology of zinc enzymes G Bahr, PE Tomatis, AJ Vila Elsevier, 2023 | 1 | 2023 |
| WS13. 06 Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient CA Colque, PE Tomatis, AGA Orio, G Dotta, DM Moreno, LG Hedemann, ... Journal of Cystic Fibrosis 21, S26, 2022 | | 2022 |
| BioF is a novel B2 metallo‐β‐lactamase from Pseudomonas sp. isolated from an on‐farm biopurification system JH Cafiero, MC Martini, MJ Lozano, C Vacca, A Lagares, PE Tomatis, ... Environmental Microbiology 24 (3), 1247-1262, 2022 | | 2022 |
| Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient CA Colque, PE Tomatis, AO AG, G Dotta, DM Moreno, LG Hedemann, ... | | 2021 |
| β-lactamase remodeling and evolution of collateral resistance in hypermutator Pseudomonas aeruginosa upon long-term antibiotic therapy CA Colque, PE Tomatis, AGA Orio, G Dotta, DM Moreno, LG Hedemann, ... bioRxiv, 2021.05. 14.444257, 2021 | | 2021 |
| B-lactamase remodeling and evolution of collateral resistance in hypermutator Pseudomonas aeruginosa upon long-term antibiotic therapy CA Colque, PE Tomatis, AG Albarracín Orio, G Dotta, DM Moreno, ... Cold Spring Harbor, 2021 | | 2021 |
| Engineered Mononuclear Variants in Bacillus cereus Metallo--lactamase BcII Are Inactive LA Abriata, LJ González, LI Llarrull, PE Tomatis, WK Myers, AL Costello, ... | | |
Alejandro J. VilaIBR (Instituto de Biologia Molecular y Celular de Rosario), CONICET-UNREmail verificata su ibr-conicet.gov.ar
