Mario Niepel
Mario Niepel
Instructor in Systems Biology, Harvard Medical School
Email verificata su hms.harvard.edu - Home page
TitoloCitata daAnno
Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data
WW Chen, B Schoeberl, PJ Jasper, M Niepel, UB Nielsen, ...
Molecular systems biology 5 (1), 2009
4112009
The nuclear pore complex: bridging nuclear transport and gene regulation
C Strambio-De-Castillia, M Niepel, MP Rout
Nature reviews Molecular cell biology 11 (7), 490, 2010
3932010
Classic and contemporary approaches to modeling biochemical reactions
WW Chen, M Niepel, PK Sorger
Genes & development 24 (17), 1861-1875, 2010
2932010
Discovery of potent and selective covalent inhibitors of JNK
T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ...
Chemistry & biology 19 (1), 140-154, 2012
2032012
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures
Q Duan, C Flynn, M Niepel, M Hafner, JL Muhlich, NF Fernandez, ...
Nucleic acids research 42 (W1), W449-W460, 2014
1872014
Non-genetic cell-to-cell variability and the consequences for pharmacology
M Niepel, SL Spencer, PK Sorger
Current opinion in chemical biology 13 (5-6), 556-561, 2009
1842009
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
M Hafner, M Niepel, M Chung, PK Sorger
Nature methods 13 (6), 521, 2016
1472016
Identification and characterization of the functional elements within the tobacco etch virus 5′ leader required for cap-independent translation
M Niepel, DR Gallie
Journal of virology 73 (11), 9080-9088, 1999
1251999
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR
Q Liu, C Xu, S Kirubakaran, X Zhang, W Hur, Y Liu, NP Kwiatkowski, ...
Cancer research 73 (8), 2574-2586, 2013
1232013
Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE)
EO Paull, DE Carlin, M Niepel, PK Sorger, D Haussler, JM Stuart
Bioinformatics 29 (21), 2757-2764, 2013
1002013
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems 6 (1), 13-24, 2018
962018
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics
Q Liu, S Kirubakaran, W Hur, M Niepel, K Westover, CC Thoreen, J Wang, ...
Journal of Biological Chemistry 287 (13), 9742-9752, 2012
932012
A cell cycle phosphoproteome of the yeast centrosome
JM Keck, MH Jones, CCL Wong, J Binkley, D Chen, SL Jaspersen, ...
Science 332 (6037), 1557, 2011
922011
The nuclear pore complex–associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly
M Niepel, C Strambio-de-Castillia, J Fasolo, BT Chait, MP Rout
The Journal of cell biology 170 (2), 225-235, 2005
832005
L1000CDS2: LINCS L1000 characteristic direction signatures search engine
Q Duan, SP Reid, NR Clark, Z Wang, NF Fernandez, AD Rouillard, ...
NPJ systems biology and applications 2, 16015, 2016
782016
Profiles of basal and stimulated receptor signaling networks predict drug response in breast cancer lines
M Niepel, M Hafner, EA Pace, M Chung, DH Chai, L Zhou, B Schoeberl, ...
Sci. Signal. 6 (294), ra84-ra84, 2013
782013
Adaptive informatics for multifactorial and high-content biological data
BL Millard, M Niepel, MP Menden, JL Muhlich, PK Sorger
Nature methods 8 (6), 487, 2011
672011
The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome
M Niepel, KR Molloy, R Williams, JC Farr, AC Meinema, N Vecchietti, ...
Molecular Biology of the Cell, mbc. E13-07-0412, 2013
642013
Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway
T Shi, M Niepel, JE McDermott, Y Gao, CD Nicora, WB Chrisler, ...
Sci. Signal. 9 (436), rs6-rs6, 2016
542016
Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis
M Fallahi‐Sichani, NJ Moerke, M Niepel, T Zhang, NS Gray, PK Sorger
Molecular systems biology 11 (3), 2015
542015
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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