Role of pancreatic stellate cells in chemoresistance in pancreatic cancer JA McCarroll, S Naim, G Sharbeen, J Lee, M Kavallaris, D Goldstein, ... Frontiers in physiology 5, 141, 2014 | 187 | 2014 |
Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers C Boyer, J Teo, P Phillips, RB Erlich, S Sagnella, G Sharbeen, T Dwarte, ... Molecular pharmaceutics 10 (6), 2435-2444, 2013 | 117 | 2013 |
A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo J Teo, JA McCarroll, C Boyer, J Youkhana, SM Sagnella, HTT Duong, ... Biomacromolecules 17 (7), 2337-2351, 2016 | 82 | 2016 |
βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer JA McCarroll, G Sharbeen, J Liu, J Youkhana, D Goldstein, N McCarthy, ... Oncotarget 6 (4), 2235, 2015 | 76 | 2015 |
A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling TW Yao, WS Kim, DMT Yu, G Sharbeen, GW McCaughan, KY Choi, P Xia, ... Molecular Cancer Research 9 (7), 948-959, 2011 | 70 | 2011 |
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition G Sharbeen, JA McCarroll, A Akerman, C Kopecky, J Youkhana, ... Cancer research 81 (13), 3461-3479, 2021 | 67 | 2021 |
Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase G Sharbeen, CWY Yee, AL Smith, CJ Jolly Journal of Experimental Medicine 209 (5), 965-974, 2012 | 64 | 2012 |
Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs J Kokkinos, RMC Ignacio, G Sharbeen, C Boyer, E Gonzales-Aloy, ... Biomaterials 240, 119742, 2020 | 57 | 2020 |
Ex vivo culture of intact human patient derived pancreatic tumour tissue J Kokkinos, G Sharbeen, KS Haghighi, RMC Ignacio, C Kopecky, ... Scientific reports 11 (1), 1944, 2021 | 39 | 2021 |
Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer G Sharbeen, J McCarroll, D Goldstein, PA Phillips Frontiers in nutrition 2, 10, 2015 | 27 | 2015 |
Can the shape of nanoparticles enable the targeting to cancer cells over healthy cells? VT Cong, W Wang, RD Tilley, G Sharbeen, PA Phillips, K Gaus, ... Advanced Functional Materials 31 (32), 2007880, 2021 | 24 | 2021 |
Identification of novel medulloblastoma cell-targeting peptides for use in selective chemotherapy drug delivery KC Tjandra, N McCarthy, L Yang, AJ Laos, G Sharbeen, PA Phillips, ... Journal of medicinal chemistry 63 (5), 2181-2193, 2019 | 23 | 2019 |
Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth Z Ma, SW Wong, H Forgham, L Esser, M Lai, MN Leiske, K Kempe, ... Biomaterials 285, 121539, 2022 | 19 | 2022 |
Delineating the role of βIV-tubulins in pancreatic cancer: βIVb-tubulin inhibition sensitizes pancreatic cancer cells to vinca alkaloids G Sharbeen, J McCarroll, J Liu, J Youkhana, LF Limbri, AV Biankin, ... Neoplasia 18 (12), 753-764, 2016 | 19 | 2016 |
Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2 ES Thientosapol, G Sharbeen, KKE Lau, D Bosnjak, T Durack, ... Nucleic acids research 45 (6), 3146-3157, 2017 | 17 | 2017 |
MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity G Sharbeen, J Youkhana, A Mawson, J McCarroll, A Nunez, A Biankin, ... Oncotarget 8 (6), 9216, 2017 | 16 | 2017 |
Biochemical Characterization of the Multidrug Regulator QacR Distinguishes Residues That Are Crucial to Multidrug Binding and Induction of qacA Transcription KM Peters, G Sharbeen, T Theis, RA Skurray, MH Brown Biochemistry 48 (41), 9794-9800, 2009 | 14 | 2009 |
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer JL Chitty, M Yam, L Perryman, AL Parker, JN Skhinas, YFI Setargew, ... Nature Cancer 4 (9), 1326-1344, 2023 | 11 | 2023 |
Interfacial curvature in confined coculture directs stromal cell activity with spatial corralling of pancreatic cancer cells S Nemec, J Lam, J Zhong, C Heu, P Timpson, Q Li, J Youkhana, ... Advanced Biology 5 (6), 2000525, 2021 | 11 | 2021 |
Australian Pancreatic Cancer Genome Initiative A., McCarroll JA, Phillips PA Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs J Kokkinos, RMC Ignacio, G Sharbeen, C Boyer, E Gonzales-Aloy, ... Biomaterials 240 (119742), 10.1016, 2020 | 11 | 2020 |