John H Viles
TitoloCitata daAnno
Structure of the recombinant full-length hamster prion protein PrP (29–231): the N terminus is highly flexible
DG Donne, JH Viles, D Groth, I Mehlhorn, TL James, FE Cohen, ...
Proceedings of the National Academy of Sciences 94 (25), 13452-13457, 1997
7991997
Copper binding to the prion protein: structural implications of four identical cooperative binding sites
JH Viles, FE Cohen, SB Prusiner, DB Goodin, PE Wright, HJ Dyson
Proceedings of the National Academy of Sciences 96 (5), 2042-2047, 1999
6461999
Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease FOLDING, COORDINATION GEOMETRY, pH DEPENDENCE, STOICHIOMETRY, AND AFFINITY OF Aβ-(1–28…
CD Syme, RC Nadal, SEJ Rigby, JH Viles
Journal of Biological Chemistry 279 (18), 18169-18177, 2004
4572004
Amyloid β protein and Alzheimer’s disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone, O Berthoumieu, NV Buchete, ...
Chemical reviews 115 (9), 3518-3563, 2015
3352015
Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
JH Viles
Coordination Chemistry Reviews 256 (19-20), 2271-2284, 2012
2692012
Preferential Cu2+ coordination by His96 and His111 induces β-sheet formation in the unstructured amyloidogenic region of the prion protein
CE Jones, SR Abdelraheim, DR Brown, JH Viles
Journal of Biological Chemistry 279 (31), 32018-32027, 2004
2592004
Involvement of a lysine residue in the N‐terminal Ni2+ and Cu2+ binding site of serum albumins: Comparison with Co2+, Cd2+ and Al3+
PJ Sadler, A Tucker, JH Viles
European Journal of Biochemistry 220 (1), 193-200, 1994
2421994
Copper Binding to the Octarepeats of the Prion Protein Affinity, Specificity, Folding, and Cooperativity: Insights from Circular Dichroism
AP Garnett, JH Viles
Journal of Biological Chemistry 278 (9), 6795-6802, 2003
2212003
Copper (II) binding to amyloid-β fibrils of Alzheimer’s disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Aβ oligomeric form
CJ Sarell, CD Syme, SEJ Rigby, JH Viles
Biochemistry 48 (20), 4388-4402, 2009
1952009
Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics
JH Viles, D Donne, G Kroon, SB Prusiner, FE Cohen, HJ Dyson, ...
Biochemistry 40 (9), 2743-2753, 2001
1912001
1H and 113Cd NMR investigations of Cd2+ and Zn2+ binding sites on serum albumin: competition with Ca2+, Ni2+, Cu2+, and Zn2+
PJ Sadler, JH Viles
Inorganic Chemistry 35 (15), 4490-4496, 1996
1871996
Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at…
CE Jones, M Klewpatinond, SR Abdelraheim, DR Brown, JH Viles
Journal of molecular biology 346 (5), 1393-1407, 2005
1662005
Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Aβ) of Alzheimer's disease
CD Syme, JH Viles
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1764 (2), 246-256, 2006
1622006
Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-β from Alzheimer disease
CJ Sarell, SR Wilkinson, JH Viles
Journal of biological chemistry 285 (53), 41533-41540, 2010
1462010
Amyloid β−Cu2+ Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2 Catalytically but Quench Hydroxyl Radicals
RC Nadal, SEJ Rigby, JH Viles
Biochemistry 47 (44), 11653-11664, 2008
1162008
Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium IMPLICATIONS FOR ALZHEIMER DISEASE
HF Stanyon, JH Viles
Journal of Biological Chemistry 287 (33), 28163-28168, 2012
1112012
Deconvoluting the Cu2+ binding modes of full-length prion protein
M Klewpatinond, P Davies, S Bowen, DR Brown, JH Viles
Journal of Biological Chemistry 283 (4), 1870-1881, 2008
1092008
Manganese binding to the prion protein
MW Brazier, P Davies, E Player, F Marken, JH Viles, DR Brown
Journal of Biological Chemistry 283 (19), 12831-12839, 2008
922008
A comparison of three fluorophores for the detection of amyloid fibers and prefibrillar oligomeric assemblies. ThT (thioflavin T); ANS (1-anilinonaphthalene-8-sulfonic acid…
ND Younan, JH Viles
Biochemistry 54 (28), 4297-4306, 2015
862015
Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals
RC Nadal, SR Abdelraheim, MW Brazier, SEJ Rigby, DR Brown, JH Viles
Free Radical Biology and Medicine 42 (1), 79-89, 2007
842007
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
Articoli 1–20