Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria JS Pinkner, H Remaut, F Buelens, E Miller, V Åberg, N Pemberton, ... Proceedings of the National Academy of Sciences 103 (47), 17897-17902, 2006 | 367 | 2006 |
Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation M Friden-Saxin, N Pemberton, K da Silva Andersson, C Dyrager, ... The Journal of Organic Chemistry 74 (7), 2755-2759, 2009 | 65 | 2009 |
Synthesis of multi ring-fused 2-pyridones via an acyl-ketene imine cyclocondensation N Pemberton, L Jakobsson, F Almqvist Organic Letters 8 (5), 935-938, 2006 | 58 | 2006 |
Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic acid bioisostere N Pemberton, H Graden, E Evertsson, E Bratt, M Lepistö, ... ACS Medicinal Chemistry Letters 3 (7), 574-578, 2012 | 57 | 2012 |
Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones N Pemberton, V Åberg, H Almstedt, A Westermark, F Almqvist The Journal of organic chemistry 69 (23), 7830-7835, 2004 | 56 | 2004 |
A class of highly selective inhibitors bind to an active state of PI3Kγ G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ... Nature chemical biology 15 (4), 348-357, 2019 | 45 | 2019 |
Discovery of highly isoform selective orally bioavailable phosphoinositide 3-kinase (PI3K)-γ inhibitors N Pemberton, M Mogemark, S Arlbrandt, P Bold, RJ Cox, C Gardelli, ... Journal of Medicinal Chemistry 61 (12), 5435-5441, 2018 | 43 | 2018 |
KHMDS Enhanced SmI2-Mediated Reformatsky Type α-Cyanation T Ankner, M Friden-Saxin, N Pemberton, T Seifert, M Grøtli, K Luthman, ... Organic Letters 12 (10), 2210-2213, 2010 | 42 | 2010 |
Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli N Pemberton, JS Pinkner, JM Jones, L Jakobsson, SJ Hultgren, ... Tetrahedron letters 48 (26), 4543-4546, 2007 | 31 | 2007 |
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly M Hedenström, H Emtenäs, N Pemberton, V Åberg, SJ Hultgren, ... Organic & biomolecular chemistry 3 (23), 4193-4200, 2005 | 29 | 2005 |
Synthesis and evaluation of dihydroimidazolo and dihydrooxazolo ring-fused 2-pyridones—targeting pilus biogenesis in uropathogenic bacteria N Pemberton, JS Pinkner, S Edvinsson, SJ Hultgren, F Almqvist Tetrahedron 64 (40), 9368-9376, 2008 | 27 | 2008 |
Cycloaddition of Δ2-Thiazolines and Acyl Ketenes under Acidic Conditions Results in Bicyclic 1,3-Oxazinones and Not 6-Acylpenams as Earlier Reported N Pemberton, H Emtenäs, D Boström, PJ Domaille, WA Greenberg, ... Organic Letters 7 (6), 1019-1021, 2005 | 27 | 2005 |
Discovery of AZD8154, a dual PI3Kγδ inhibitor for the treatment of asthma MWD Perry, K Bjorhall, P Bold, M Brulls, U Borjesson, J Carlsson, ... Journal of Medicinal Chemistry 64 (12), 8053-8075, 2021 | 24 | 2021 |
Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration MWD Perry, K Björhall, B Bonn, J Carlsson, Y Chen, A Eriksson, ... Journal of Medicinal Chemistry 60 (12), 5057-5071, 2017 | 24 | 2017 |
Chroman-4-one and chromone based somatostatin β-turn mimetics M Friden-Saxin, T Seifert, M Malo, K da Silva Andersson, N Pemberton, ... European Journal of Medicinal Chemistry 114, 59-64, 2016 | 16 | 2016 |
Enantiomeric purity determination by NMR: proving the purity of a single enantiomer RJ Lewis, MA Bernstein, HF Chang, D Chapman, N Pemberton Tetrahedron: Asymmetry 24 (13-14), 866-870, 2013 | 11 | 2013 |
Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones N Pemberton, E Chorell, F Almqvist Microwave-Assisted Synthesis of Heterocycles, 1-30, 2006 | 9 | 2006 |
Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA M Andréasson, N Bhuma, N Pemberton, E Chorell Chemistry–A European Journal 28 (65), e202202020, 2022 | 5 | 2022 |
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1, 3, 4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism L Ripa, J Sandmark, G Hughes, I Shamovsky, A Gunnarsson, ... Journal of Medicinal Chemistry 66 (20), 14188-14207, 2023 | 3 | 2023 |
Amino methylated 2-pyridinones SJ Hultgren, JS Pinkner, F Almqvist, N Pemberton, V Aberg, A Larsson US Patent 7,411,066, 2008 | 3 | 2008 |