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Ulf Dettmer
Ulf Dettmer
Harvard Medical School/Brigham and Women's Hospital
Verified email at harvard.edu
Title
Cited by
Cited by
Year
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ...
Nature communications 6 (1), 7314, 2015
3272015
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells
U Dettmer, AJ Newman, ES Luth, T Bartels, D Selkoe
Journal of Biological Chemistry 288 (9), 6371-6385, 2013
2782013
Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for Parkinson treatment
S Fanning, A Haque, T Imberdis, V Baru, MI Barrasa, S Nuber, D Termine, ...
Molecular cell 73 (5), 1001-1014. e8, 2019
2122019
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
U Dettmer, AJ Newman, VE von Saucken, T Bartels, D Selkoe
Proceedings of the National Academy of Sciences 112 (31), 9596-9601, 2015
1772015
Parkinson’s disease: proteinopathy or lipidopathy?
S Fanning, D Selkoe, U Dettmer
NPJ Parkinson's disease 6 (1), 3, 2020
1602020
Abrogating native α-synuclein tetramers in mice causes a L-DOPA-responsive motor syndrome closely resembling Parkinson’s disease
S Nuber, M Rajsombath, G Minakaki, J Winkler, CP Müller, M Ericsson, ...
Neuron 100 (1), 75-90. e5, 2018
1202018
New insights into cellular α-synuclein homeostasis in health and disease
U Dettmer, D Selkoe, T Bartels
Current opinion in neurobiology 36, 15-22, 2016
1012016
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity
ES Luth, T Bartels, U Dettmer, NC Kim, DJ Selkoe
Biochemistry 54 (2), 279-292, 2015
922015
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells
U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ...
Human Molecular Genetics 26 (18), 3466-3481, 2017
822017
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase
T Imberdis, J Negri, N Ramalingam, E Terry-Kantor, GPH Ho, S Fanning, ...
Proceedings of the National Academy of Sciences 116 (41), 20760-20769, 2019
722019
Defining the native state of α-synuclein
D Selkoe, U Dettmer, E Luth, N Kim, A Newman, T Bartels
Neurodegenerative Diseases 13 (2-3), 114-117, 2014
562014
Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex
U Dettmer, PH Kuhn, C Abou-Ajram, SF Lichtenthaler, M Krüger, ...
Journal of biological chemistry 285 (34), 26174-26181, 2010
552010
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
R Kayed, U Dettmer, SE Lesné
Journal of Parkinson's Disease 10 (3), 791-818, 2020
472020
A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice
S Nuber, AY Nam, MM Rajsombath, H Cirka, X Hronowski, J Wang, ...
Annals of Neurology 89 (1), 74-90, 2021
402021
The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex
C Haffner, U Dettmer, T Weiler, C Haass
Journal of biological chemistry 282 (14), 10632-10638, 2007
402007
A new method for quantitative immunoblotting of endogenous α-synuclein
AJ Newman, D Selkoe, U Dettmer
PLoS One 8 (11), e81314, 2013
392013
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form
TJ Collier, KR Srivastava, C Justman, T Grammatopoulous, B Hutter-Paier, ...
Neurobiology of disease 106, 191-204, 2017
352017
Rationally designed variants of α-synuclein illuminate its in vivo structural properties in health and disease
U Dettmer
Frontiers in Neuroscience 12, 403598, 2018
342018
Vesicle trafficking and lipid metabolism in synucleinopathy
S Fanning, D Selkoe, U Dettmer
Acta neuropathologica 141 (4), 491-510, 2021
322021
Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice
KE Glajch, TE Moors, Y Chen, PA Bechade, AY Nam, MM Rajsombath, ...
Proceedings of the National Academy of Sciences 118 (31), e2103425118, 2021
242021
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