Silvia Soddu
Silvia Soddu
Regina Elena Cancer Institute
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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi, B Cecchinelli, T Bruno, I Manni, Y Higashimoto, S Saito, ...
Nature cell biology 4 (1), 11-19, 2002
p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis
I Cordone, S Masi, FR Mauro, S Soddu, O Morsilli, T Valentini, ML Vegna, ...
Blood, The Journal of the American Society of Hematology 91 (11), 4342-4349, 1998
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
C Rinaldo, A Prodosmo, F Mancini, S Iacovelli, A Sacchi, F Moretti, ...
Molecular cell 25 (5), 739-750, 2007
p53 inhibits α6β4 integrin survival signaling by promoting the caspase 3–dependent cleavage of AKT/PKB
RE Bachelder, MJ Ribick, A Marchetti, R Falcioni, S Soddu, KR Davis, ...
The Journal of cell biology 147 (5), 1063-1072, 1999
NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest
I Manni, G Mazzaro, A Gurtner, R Mantovani, U Haugwitz, K Krause, ...
Journal of Biological Chemistry 276 (8), 5570-5576, 2001
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells
F Moretti, A Farsetti, S Soddu, S Misiti, M Crescenzi, S Filetti, M Andreoli, ...
Oncogene 14 (6), 729-740, 1997
TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
R Tomasini, AA Samir, A Carrier, D Isnardon, B Cecchinelli, S Soddu, ...
Journal of Biological Chemistry 278 (39), 37722-37729, 2003
Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways
B Valentinis, G Romano, F Peruzzi, A Morrione, M Prisco, S Soddu, ...
Journal of Biological Chemistry 274 (18), 12423-12430, 1999
Interference with p53 protein inhibits hematopoietic and muscle differentiation.
S Soddu, G Blandino, R Scardigli, S Coen, A Marchetti, MG Rizzo, ...
The Journal of Cell Biology 134 (1), 193-204, 1996
p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle
M Ciciarello, R Mangiacasale, M Casenghi, MZ Limongi, M D'Angelo, ...
Journal of Biological Chemistry 276 (22), 19205-19213, 2001
From p63 to p53 across p73
S Strano, M Rossi, G Fontemaggi, E Munarriz, S Soddu, A Sacchi, ...
FEBS letters 490 (3), 163-170, 2001
p53 regulates myogenesis by triggering the differentiation activity of pRb
A Porrello, MA Cerone, S Coen, A Gurtner, G Fontemaggi, L Cimino, ...
The Journal of cell biology 151 (6), 1295-1304, 2000
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
T Bruno, F De Nicola, S Iezzi, D Lecis, C D'Angelo, M Di Padova, N Corbi, ...
Cancer cell 10 (6), 473-486, 2006
HIPK2: a multitalented partner for transcription factors in DNA damage response and development
C Rinaldo, A Prodosmo, F Siepi, S Soddu
Biochemistry and Cell Biology 85 (4), 411-418, 2007
Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis
B Cecchinelli, L Lavra, C Rinaldo, S Iacovelli, A Gurtner, A Gasbarri, ...
Molecular and cellular biology 26 (12), 4746-4757, 2006
p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation
A Tritarelli, E Oricchio, M Ciciarello, R Mangiacasale, A Palena, P Lavia, ...
Molecular biology of the cell 15 (8), 3751-3757, 2004
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
GM Pierantoni, C Rinaldo, M Mottolese, A Di Benedetto, F Esposito, ...
The Journal of clinical investigation 117 (3), 693-702, 2007
Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
V Di Stefano, C Rinaldo, A Sacchi, S Soddu, G D'Orazi
Experimental cell research 293 (2), 311-320, 2004
Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers
G Federici, S Soddu
Journal of Experimental & Clinical Cancer Research 39, 1-12, 2020
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation
R Amato, L D’Antona, G Porciatti, V Agosti, M Menniti, C Rinaldo, N Costa, ...
Journal of molecular medicine 87, 1221-1239, 2009
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