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David Leggett
David Leggett
Affiliazione sconosciuta
Email verificata su theleggettfamily.com
Titolo
Citata da
Citata da
Anno
Multiple associated proteins regulate proteasome structure and function
DS Leggett, J Hanna, A Borodovsky, B Crosas, M Schmidt, RT Baker, ...
Molecular cell 10 (3), 495-507, 2002
7552002
Proteasome subunit Rpn1 binds ubiquitin-like protein domains
S Elsasser, RR Gali, M Schwickart, CN Larsen, DS Leggett, B Müller, ...
Nature cell biology 4 (9), 725-730, 2002
5732002
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release
A Köhler, P Cascio, DS Leggett, KM Woo, AL Goldberg, D Finley
Molecular cell 7 (6), 1143-1152, 2001
5452001
Suppression of cancer relapse and metastasis by inhibiting cancer stemness
Y Li, HA Rogoff, S Keates, Y Gao, S Murikipudi, K Mikule, D Leggett, W Li, ...
Proceedings of the National Academy of Sciences 112 (6), 1839-1844, 2015
4722015
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation
J Hanna, NA Hathaway, Y Tone, B Crosas, S Elsasser, DS Kirkpatrick, ...
Cell 127 (1), 99-111, 2006
4282006
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
N Munshi, S Jeay, Y Li, CR Chen, DS France, MA Ashwell, J Hill, ...
Molecular cancer therapeutics 9 (6), 1544-1553, 2010
3752010
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities
B Crosas, J Hanna, DS Kirkpatrick, DP Zhang, Y Tone, NA Hathaway, ...
Cell 127 (7), 1401-1413, 2006
3672006
Ubiquitin depletion as a key mediator of toxicity by translational inhibitors
J Hanna, DS Leggett, D Finley
Molecular and cellular biology 23 (24), 9251-9261, 2003
2612003
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast
DS Leggett, MH Glickman, D Finley
Ubiquitin-Proteasome Protocols, 57-70, 2005
1242005
STAT3 pathway inhibitors and cancer stem cell inhibitors
Z Jiang, CJ Li, W Li, D Leggett
US Patent 8,877,803, 2014
312014
A dose-escalation phase I study of a first-in-class cancer stemness inhibitor in patients with advanced malignancies.
A Langleben, JG Supko, SJ Hotte, G Batist, HW Hirte, H Rogoff, Y Li, W Li, ...
Journal of Clinical Oncology 31 (15_suppl), 2542-2542, 2013
282013
A phase I extension study of BBI608, a first-in-class cancer stem cell (CSC) inhibitor, in patients with advanced solid tumors.
DJ Jonker, J Stephenson, WJ Edenfield, JG Supko, Y Li, W Li, M Hitron, ...
Journal of Clinical Oncology 32 (15_suppl), 2546-2546, 2014
272014
A phase 1b study of the cancer stem cell inhibitor BBI608 administered with paclitaxel in patients with advanced malignancies.
M Hitron, J Stephenson, KN Chi, WJ Edenfield, D Leggett, Y Li, W Li, ...
Journal of Clinical Oncology 32 (15_suppl), 2530-2530, 2014
242014
ARQ 197, a highly selective small molecule inhibitor of c-Met, with selective antitumor properties in a broad spectrum of human cancer cells
S Jeay, N Munshi, J Hill, M Moussa, M Ashwell, D Leggett, C Li
Cancer Research 67 (9_Supplement), 2369-2369, 2007
242007
Biochemical characterization of Caenorhabditis elegans UBC-1: self-association and auto-ubiquitination of a RAD6-like ubiquitin-conjugating enzyme in vitro
SD LEGGETT, MEP CANDIDO
Biochemical Journal 327 (2), 357-361, 1997
191997
High-content fluorescent-based assay for screening activators of DNA damage checkpoint pathways
B Zhang, X Gu, U Uppalapati, MA Ashwell, DS Leggett, CJ Li
Journal of biomolecular screening 13 (6), 538-543, 2008
182008
Caenorhabditis elegans UBC-1, a Ubiquitin-Conjugating Enzyme Homologous to Yeast RAD6/UBC2, Contains a Novel Carboxy-Terminal Extension That Is …
DS LEGGETT, D JONES, EPM CANDIDO
DNA and cell biology 14 (10), 883-891, 1995
171995
Compounds and compositions for targeting cancer stem cells
CJ Li, D Leggett, Y Li, W Li
US Patent 9,084,766, 2015
112015
Broad spectrum anti-cancer activity of ARQ 197, a highly selective oral c-Met Inhibitor, in multiple xenograft models
Y Li, D Chen, W Zhou, W Li, J Sun, E Hyatt, Z Jiang, S Makhija, ...
Cancer Research 67 (9_Supplement), 2216-2216, 2007
112007
Stat3 pathway inhibitors and cancer stem cell inhibitors
Z Jiang, CJ Li, W Li, D Leggett
US Patent 9,834,532, 2017
92017
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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