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Stephen J. Polyak
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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
MJ Gale Jr, MJ Korth, NM Tang, SL Tan, DA Hopkins, TE Dever, ...
Virology 230 (2), 217-227, 1997
10691997
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation
M Gale Jr, CM Blakely, B Kwieciszewski, SL Tan, M Dossett, NM Tang, ...
Molecular and cellular biology, 1998
8081998
Arbidol as a broad-spectrum antiviral: an update
J Blaising, SJ Polyak, EI Pécheur
Antiviral research 107, 84-94, 2014
5482014
Arbidol: a broad-spectrum antiviral compound that blocks viral fusion
YS Boriskin, IA Leneva, EI Pecheur, SJ Polyak
Current medicinal chemistry 15 (10), 997-1005, 2008
5242008
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
SJ Polyak, KSA Khabar, DM Paschal, HJ Ezelle, G Duverlie, GN Barber, ...
Journal of virology 75 (13), 6095-6106, 2001
4532001
Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins
ST Shi, SJ Polyak, H Tu, DR Taylor, DR Gretch, MMC Lai
Virology 292 (2), 198-210, 2002
4212002
Identification of hepatoprotective flavonolignans from silymarin
SJ Polyak, C Morishima, V Lohmann, S Pal, DYW Lee, Y Liu, TN Graf, ...
Proceedings of the national academy of sciences 107 (13), 5995-5999, 2010
3892010
Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy
SJ Polyak, KSA Khabar, M Rezeiq, DR Gretch
Journal of virology 75 (13), 6209-6211, 2001
3102001
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-κB signaling, and HCV infection by standardized silymarin
SJ Polyak, C Morishima, MC Shuhart, CC Wang, Y Liu, DYW Lee
Gastroenterology 132 (5), 1925-1936, 2007
3002007
Multiple effects of silymarin on the hepatitis C virus lifecycle
J Wagoner, A Negash, OJ Kane, LE Martinez, Y Nahmias, N Bourne, ...
Hepatology 51 (6), 1912-1921, 2010
2912010
Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry
JE Kyle, X Zhang, KK Weitz, ME Monroe, YM Ibrahim, RJ Moore, J Cha, ...
Analyst 141 (5), 1649-1659, 2016
2392016
Myeloid suppressor cells induced by hepatitis C virus suppress T‐cell responses through the production of reactive oxygen species
RS Tacke, HC Lee, C Goh, J Courtney, SJ Polyak, HR Rosen, YS Hahn
Hepatology 55 (2), 343-353, 2012
2332012
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase
Y He, H Nakao, SL Tan, SJ Polyak, P Neddermann, S Vijaysri, BL Jacobs, ...
Journal of virology 76 (18), 9207-9217, 2002
2232002
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection
JA Mengshol, L Golden-Mason, T Arikawa, M Smith, T Niki, R McWilliams, ...
PloS one 5 (3), e9504, 2010
2192010
Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon‐sensitive virus replication
SJ Polyak, DM Paschal, S McArdle, MJ Jr, D Moradpour, DR Gretch
Hepatology 29 (4), 1262-1271, 1999
1891999
Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection
SJ Polyak, S McArdle, SL Liu, DG Sullivan, M Chung, WT Hofgärtner, ...
Journal of virology 72 (5), 4288-4296, 1998
1861998
The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses
EI Pécheur, V Borisevich, P Halfmann, JD Morrey, DF Smee, M Prichard, ...
Journal of virology 90 (6), 3086-3092, 2016
1792016
Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients
DR Gretch, SJ Polyak, JJ Wilson, RL Carithers Jr, JD Perkins, L Corey
Journal of virology 70 (11), 7622-7631, 1996
1751996
Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection
C Morishima, MC Shuhart, CC Wang, DM Paschal, MC Apodaca, Y Liu, ...
Gastroenterology 138 (2), 671-681. e2, 2010
1692010
Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection
SJ Polyak, P Ferenci, JM Pawlotsky
Hepatology 57 (3), 1262-1271, 2013
1622013
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