| Design of an in vitro biocatalytic cascade for the manufacture of islatravir MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske, KR Campos, ... Science 366 (6470), 1255-1259, 2019 | 465* | 2019 |
| Asymmetric reduction of activated alkenes by pentaerythritol tetranitrate reductase: specificity and control of stereochemical outcome by reaction optimisation A Fryszkowska, H Toogood, M Sakuma, JM Gardiner, GM Stephens, ... Advanced synthesis & catalysis 351 (17), 2976-2990, 2009 | 136 | 2009 |
| Biocatalysis with thermostable enzymes: structure and properties of a thermophilic ‘ene’‐reductase related to old yellow enzyme BV Adalbjörnsson, HS Toogood, A Fryszkowska, CR Pudney, TA Jowitt, ... ChemBioChem 11 (2), 197-207, 2010 | 134 | 2010 |
| Biocatalysis in drug discovery and development A Fryszkowska, PN Devine Current Opinion in Chemical Biology 55, 151-160, 2020 | 126 | 2020 |
| Highly Enantioselective Reduction of β,β-Disubstituted Aromatic Nitroalkenes Catalyzed by Clostridium sporogenes A Fryszkowska, K Fisher, JM Gardiner, GM Stephens The Journal of organic chemistry 73 (11), 4295-4298, 2008 | 117 | 2008 |
| Structure‐based insight into the asymmetric bioreduction of the C C double bond of α, β‐unsaturated nitroalkenes by pentaerythritol tetranitrate reductase HS Toogood, A Fryszkowska, V Hare, K Fisher, A Roujeinikova, D Leys, ... Advanced synthesis & catalysis 350 (17), 2789-2803, 2008 | 104 | 2008 |
| Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19 JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ... ACS Central Science 7 (12), 1980-1985, 2021 | 100 | 2021 |
| A site‐saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity HS Toogood, A Fryszkowska, M Hulley, M Sakuma, D Mansell, ... ChemBioChem 12 (5), 738-749, 2011 | 79 | 2011 |
| Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site‐saturated libraries ME Hulley, HS Toogood, A Fryszkowska, D Mansell, GM Stephens, ... ChemBioChem 11 (17), 2433-2447, 2010 | 68 | 2010 |
| Canada, KA; Devine, PN; Duan, D MA Huffman, A Fryszkowska, O Alvizo, M Borra-Garske, KR Campos Forstater, J. H, 1255-1259, 2019 | 59 | 2019 |
| Enzymatic desymmetrization of 3-arylglutaric acid anhydrides A Fryszkowska, M Komar, D Koszelewski, R Ostaszewski Tetrahedron: Asymmetry 16 (14), 2475-2485, 2005 | 46 | 2005 |
| Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug P Ramesh, D Suman, KSN Reddy Synthesis 50 (02), 211-226, 2018 | 37 | 2018 |
| A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria A Fryszkowska, K Fisher, JM Gardiner, GM Stephens Organic & biomolecular chemistry 8 (3), 533-535, 2010 | 36 | 2010 |
| Synthesis of Liquid Crystalline 4H-Benzo[1,2,4]thiadiazines and Generation of Persistent Radicals J Zienkiewicz, A Fryszkowska, K Zienkiewicz, F Guo, P Kaszynski, ... The Journal of Organic Chemistry 72 (9), 3510-3520, 2007 | 30 | 2007 |
| Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical … A Fryszkowska, H Toogood, M Sakuma, GM Stephens, JM Gardiner, ... Catalysis Science & Technology 1 (6), 948-957, 2011 | 29 | 2011 |
| Studies on enzymatic synthesis of chiral non-racemic 3-arylglutaric acid monoesters A Fryszkowska, M Komar, D Koszelewski, R Ostaszewski Tetrahedron: Asymmetry 17 (6), 961-966, 2006 | 26 | 2006 |
| Structural insights into the ene-reductase synthesis of profens J Waller, HS Toogood, V Karuppiah, NJW Rattray, DJ Mansell, D Leys, ... Organic & Biomolecular Chemistry 15 (20), 4440-4448, 2017 | 24 | 2017 |
| Synthesis of islatravir enabled by a catalytic, enantioselective alkynylation of a ketone NR Patel, CC Nawrat, M McLaughlin, Y Xu, MA Huffman, H Yang, H Li, ... Organic Letters 22 (12), 4659-4664, 2020 | 23 | 2020 |
| A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins A Fryszkowska, C An, O Alvizo, G Banerjee, KA Canada, Y Cao, ... Science 376 (6599), 1321-1327, 2022 | 21 | 2022 |
| Electrochemical activation of galactose oxidase: Mechanistic studies and synthetic applications S Zhang, S Ruccolo, A Fryszkowska, A Klapars, N Marshall, NA Strotman ACS Catalysis 11 (12), 7270-7280, 2021 | 21 | 2021 |
john gardinerManchester UniversityEmail verificata su manchester.ac.uk
