Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain JD Osteen, V Herzig, J Gilchrist, JJ Emrick, C Zhang, X Wang, J Castro, ... Nature 534 (7608), 494-499, 2016 | 280 | 2016 |
Crystallographic insights into sodium-channel modulation by the β4 subunit J Gilchrist, S Das, F Van Petegem, F Bosmans Proceedings of the National Academy of Sciences 110 (51), E5016-E5024, 2013 | 105 | 2013 |
The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel CJ Peters, JM Gilchrist, J Tien, NP Bethel, L Qi, T Chen, L Wang, YN Jan, ... Neuron 97 (5), 1063-1077. e4, 2018 | 79 | 2018 |
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a NS Bende, S Dziemborowicz, M Mobli, V Herzig, J Gilchrist, J Wagner, ... Nature communications 5 (1), 4350, 2014 | 76 | 2014 |
Animal toxins influence voltage-gated sodium channel function J Gilchrist, BM Olivera, F Bosmans Voltage Gated Sodium Channels, 203-229, 2014 | 74 | 2014 |
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis D Crottès, YHT Lin, CJ Peters, JM Gilchrist, AP Wiita, YN Jan, LY Jan Proceedings of the National Academy of Sciences 116 (26), 13026-13035, 2019 | 61 | 2019 |
Binary architecture of the Nav1.2-β2 signaling complex S Das, J Gilchrist, F Bosmans, F Van Petegem Elife 5, e10960, 2016 | 51 | 2016 |
Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents J Gilchrist, S Dutton, M Diaz-Bustamante, A McPherson, N Olivares, ... ACS chemical biology 9 (5), 1204-1212, 2014 | 51 | 2014 |
NaV1. 1 inhibition can reduce visceral hypersensitivity J Salvatierra, J Castro, A Erickson, Q Li, J Braz, J Gilchrist, L Grundy, ... JCI insight 3 (11), 2018 | 41 | 2018 |
Animal toxins can alter the function of Nav1. 8 and Nav1. 9 J Gilchrist, F Bosmans Toxins 4 (8), 620-632, 2012 | 38 | 2012 |
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami V Herzig, M Ikonomopoulou, JJ Smith, S Dziemborowicz, J Gilchrist, ... Scientific reports 6 (1), 29538, 2016 | 30 | 2016 |
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity JS Wingerd, CA Mozar, CA Ussing, SS Murali, YKY Chin, ... Scientific reports 7 (1), 974, 2017 | 22 | 2017 |
Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents WG Schroeder, LM Mitrescu, ML Hart, R Unnithan, JM Gilchrist, EE Smith, ... BioTechniques 46 (3), 2009 | 19 | 2009 |
Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix MP Ikonomopoulou, JJ Smith, V Herzig, SS Pineda, S Dziemborowicz, ... Toxicon 123, 62-70, 2016 | 15 | 2016 |
Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry MA Early, M Lishnevsky, JM Gilchrist, DM Higgins, IM Orme, WA Muller, ... Experimental and molecular pathology 87 (2), 152-158, 2009 | 15 | 2009 |
Using voltage‐sensor toxins and their molecular targets to investigate NaV1.8 gating J Gilchrist, F Bosmans The Journal of Physiology 596 (10), 1863-1872, 2018 | 14 | 2018 |
Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice M Lishnevsky, LC Young, SJ Woods, SD Groshong, RJ Basaraba, ... Experimental and molecular pathology 97 (1), 128-136, 2014 | 11 | 2014 |
Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1. 7 DB Rupasinghe, V Herzig, I Vetter, Z Dekan, J Gilchrist, F Bosmans, ... Biochemical pharmacology 181, 114080, 2020 | 10 | 2020 |
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses M Early, WG Schroeder, R Unnithan, JM Gilchrist, WA Muller, A Schenkel PeerJ 5, e3555, 2017 | 5 | 2017 |
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1. 8 with a Unique Mechanism of Action JM Gilchrist, ND Yang, V Jiang, BD Moyer Molecular Pharmacology 105 (3), 233-249, 2024 | | 2024 |