Adam E. Locke
Adam E. Locke
Director, Statistical Genetics, Regeneron Genetics Center
Email verificata su regeneron.com
Titolo
Citata da
Citata da
Anno
Genetic studies of body mass index yield new insights for obesity biology
AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day, C Powell, ...
Nature 518 (7538), 197-206, 2015
27192015
Defining the role of common variation in the genomic and biological architecture of adult human height
AR Wood, T Esko, J Yang, S Vedantam, TH Pers, S Gustafsson, AY Chu, ...
Nature genetics 46 (11), 1173-1186, 2014
15122014
Next-generation genotype imputation service and methods
S Das, L Forer, S Schnherr, C Sidore, AE Locke, A Kwong, SI Vrieze, ...
Nature genetics 48 (10), 1284-1287, 2016
9562016
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, AE Locke, ...
Nature 518 (7538), 187-196, 2015
9262015
The genetic architecture of type 2 diabetes
C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, ...
Nature 536 (7614), 41-47, 2016
7342016
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, ...
Nature genetics 50 (11), 1505-1513, 2018
3892018
Rare and low-frequency coding variants alter human adult height
E Marouli, M Graff, C Medina-Gomez, KS Lo, AR Wood, TR Kjaer, RS Fine, ...
Nature 542 (7640), 186-190, 2017
3662017
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
JC Randall, TW Winkler, Z Kutalik, SI Berndt, AU Jackson, KL Monda, ...
PLoS Genet 9 (6), e1003500, 2013
3202013
Quality control and conduct of genome-wide association meta-analyses
TW Winkler, FR Day, DC Croteau-Chonka, AR Wood, AE Locke, R Mgi, ...
Nature protocols 9 (5), 1192-1212, 2014
2752014
Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project
SB Freeman, LH Bean, EG Allen, SW Tinker, AE Locke, C Druschel, ...
Genetics in Medicine 10 (3), 173-180, 2008
2732008
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mgi, ME Reschen, ...
Nature genetics 47 (12), 1415-1425, 2015
2682015
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
LA Lange, Y Hu, H Zhang, C Xue, EM Schmidt, ZZ Tang, C Bizon, ...
The American Journal of Human Genetics 94 (2), 233-245, 2014
1922014
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Y Lu, FR Day, S Gustafsson, ML Buchkovich, J Na, V Bataille, ...
Nature communications 7 (1), 1-15, 2016
1662016
Population genetic differentiation of height and body mass index across Europe
MR Robinson, G Hemani, C Medina-Gomez, M Mezzavilla, T Esko, ...
Nature genetics 47 (11), 1357-1362, 2015
1482015
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
V Turcot, Y Lu, HM Highland, C Schurmann, AE Justice, RS Fine, ...
Nature genetics 50 (1), 26-41, 2018
1342018
Genetic evidence of assortative mating in humans
MR Robinson, A Kleinman, M Graff, AAE Vinkhuyzen, D Couper, ...
Nature Human Behaviour 1 (1), 1-13, 2017
1232017
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
AR Majithia, J Flannick, P Shahinian, M Guo, MA Bray, P Fontanillas, ...
Proceedings of the National Academy of Sciences 111 (36), 13127-13132, 2014
1152014
An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects
C Ackerman, AE Locke, E Feingold, B Reshey, K Espana, J Thusberg, ...
The American Journal of Human Genetics 91 (4), 646-659, 2012
852012
Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome
AE Locke, KJ Dooley, SW Tinker, SY Cheong, E Feingold, EG Allen, ...
Genetic epidemiology 34 (6), 613-623, 2010
812010
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus
A Mahajan, X Sim, HJ Ng, A Manning, MA Rivas, HM Highland, AE Locke, ...
PLoS Genet 11 (1), e1004876, 2015
772015
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