Photoswitchable inhibitors of microtubule dynamics optically control mitosis and cell death M Borowiak, W Nahaboo, M Reynders, K Nekolla, P Jalinot, J Hasserodt, ... Cell 162 (2), 403-411, 2015 | 375 | 2015 |
A microtubule-organizing center directing intracellular transport in the early mouse embryo J Zenker, MD White, RM Templin, RG Parton, O Thorn-Seshold, ... Science 357 (6354), 925-928, 2017 | 111 | 2017 |
Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis A Singh, T Saha, I Begemann, A Ricker, H Nüsse, O Thorn-Seshold, ... Nature Cell Biology 20 (10), 1126-1133, 2018 | 85 | 2018 |
Microtubules control cellular shape and coherence in amoeboid migrating cells A Kopf, J Renkawitz, R Hauschild, I Girkontaite, K Tedford, J Merrin, ... Journal of Cell Biology 219 (6), e201907154, 2020 | 82 | 2020 |
Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton A Müller-Deku, JCM Meiring, K Loy, Y Kraus, C Heise, R Bingham, ... Nature communications 11 (1), 4640, 2020 | 58 | 2020 |
Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fidelity via tubulin polymerization at the calyx of held K Eguchi, Z Taoufiq, O Thorn-Seshold, D Trauner, M Hasegawa, ... Journal of Neuroscience 37 (25), 6043-6052, 2017 | 55 | 2017 |
Optical manipulation of F-actin with photoswitchable small molecules M Borowiak, F Küllmer, F Gegenfurtner, S Peil, V Nasufovic, S Zahler, ... Journal of the American Chemical Society 142 (20), 9240-9249, 2020 | 52 | 2020 |
A robust, high-sensitivity stealth probe for peptidases O Thorn-Seshold, M Vargas-Sanchez, S McKeon, J Hasserodt Chemical communications 48 (50), 6253-6255, 2012 | 49 | 2012 |
A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton L Gao, JCM Meiring, Y Kraus, M Wranik, T Weinert, SD Pritzl, R Bingham, ... Cell Chemical Biology 28 (2), 228-241. e6, 2021 | 46* | 2021 |
Pyrrole Hemithioindigo Antimitotics with Near‐Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single‐Cell Precision A Sailer, JCM Meiring, C Heise, LN Pettersson, A Akhmanova, ... Angewandte Chemie International Edition 60 (44), 23695-23704, 2021 | 42 | 2021 |
Hemithioindigos for cellular photopharmacology: desymmetrised molecular switch scaffolds enabling design control over the isomer‐dependency of potent antimitotic bioactivity A Sailer, F Ermer, Y Kraus, FH Lutter, C Donau, M Bremerich, J Ahlfeld, ... ChemBioChem 20 (10), 1305-1314, 2019 | 42 | 2019 |
Models for randomly hyperbranched polymers: Theory and simulation D Konkolewicz, O Thorn-Seshold, A Gray-Weale The Journal of chemical physics 129 (5), 2008 | 39 | 2008 |
Selective, modular probes for thioredoxins enabled by rational tuning of a unique disulfide structure motif JG Felber, L Zeisel, L Poczka, K Scholzen, S Busker, MS Maier, ... Journal of the American Chemical Society 143 (23), 8791-8803, 2021 | 32 | 2021 |
In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P … L Gao, JCM Meiring, A Varady, IE Ruider, C Heise, M Wranik, CD Velasco, ... Journal of the American Chemical Society 144 (12), 5614-5628, 2022 | 31 | 2022 |
Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo A Sailer, F Ermer, Y Kraus, R Bingham, FH Lutter, J Ahlfeld, ... Beilstein Journal of Organic Chemistry 16 (1), 125-134, 2020 | 29 | 2020 |
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically JG Felber, L Poczka, KC Scholzen, L Zeisel, MS Maier, S Busker, ... Nature Communications 13 (1), 1754, 2022 | 25 | 2022 |
Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1, 2-thiaselenane redox probe L Zeisel, JG Felber, KC Scholzen, L Poczka, D Cheff, MS Maier, Q Cheng, ... Chem 8 (5), 1493-1517, 2022 | 22 | 2022 |
Photoswitchable epothilone‐based microtubule stabilisers allow GFP‐imaging‐compatible, optical control over the microtubule cytoskeleton L Gao, JCM Meiring, C Heise, A Rai, A Müller‐Deku, A Akhmanova, ... Angewandte Chemie 134 (10), e202114614, 2022 | 17 | 2022 |
BTDAzo: A photoswitchable Trpc5 channel activator M Müller, K Niemeyer, N Urban, NK Ojha, F Zufall, T Leinders‐Zufall, ... Angewandte Chemie 134 (36), e202201565, 2022 | 13 | 2022 |
Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors Y Kraus, C Glas, B Melzer, L Gao, C Heise, M Preusse, J Ahlfeld, ... European Journal of Medicinal Chemistry 186, 111865, 2020 | 12 | 2020 |