On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments M Pirazzini, O Leka, G Zanetti, O Rossetto, C Montecucco Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (3), 467-474, 2016 | 106 | 2016 |
The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain I Zornetta, D Azarnia Tehran, G Arrigoni, F Anniballi, L Bano, O Leka, ... Scientific reports 6 (1), 30257, 2016 | 104 | 2016 |
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals D Azarnia Tehran, M Pirazzini, O Leka, A Mattarei, F Lista, T Binz, ... Cellular Microbiology 19 (2), e12647, 2017 | 47 | 2017 |
Diphtheria toxin conformational switching at acidic pH O Leka, F Vallese, M Pirazzini, P Berto, C Montecucco, G Zanotti The FEBS journal 281 (9), 2115-2122, 2014 | 40 | 2014 |
A novel inhibitor prevents the peripheral neuroparalysis of botulinum neurotoxins D Azarnia Tehran, G Zanetti, O Leka, F Lista, S Fillo, T Binz, CC Shone, ... Scientific Reports 5 (1), 17513, 2015 | 34 | 2015 |
Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice M Pirazzini, A Grinzato, D Corti, S Barbieri, O Leka, F Vallese, M Tonellato, ... The Journal of Clinical Investigation 131 (22), 2021 | 8 | 2021 |
Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3 O Leka, Y Wu, X Li, RA Kammerer Journal of Biological Chemistry 296, 2021 | 7 | 2021 |
Structural insights into the interaction of botulinum neurotoxin a with its neuronal receptor SV2C X Li, C Brunner, Y Wu, O Leka, G Schneider, RA Kammerer Toxicon 175, 36-43, 2020 | 2 | 2020 |
A DARPin promotes faster onset of botulinum neurotoxin A1 action O Leka, Y Wu, G Zanetti, S Furler, T Reinberg, J Marinho, JV Schaefer, ... Nature Communications 14 (1), 8317, 2023 | | 2023 |
A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors M Amer, O Leka, P Jasko, D Frey, X Li, RA Kammerer Scientific Reports 13 (1), 10159, 2023 | | 2023 |
A DARPin Increases the Catalytic Activity of Botulinum Neurotoxin A1 O Leka, Y Wu, G Zanetti, S Furler, T Reinberg, J Marinho, J Schaefer, ... | | 2023 |
Antigen-Binding Fragments From Purified Human Monoclonal Antibodies Open to the Intrathecal Therapy of Tetanus F Fabris, P Šoštarić, P Meglić, T Marika, G Alessandro, C Davide, ... Toxins 2022 6th International Conference, s61-s62, 2022 | | 2022 |
Extremely potent Human Monoclonal Antibodies for the Prophylaxis and Therapy of Tetanus M Pirazzini, A Grinzato, D Corti, S Barbieri, O Leka, F Vallese, M Tonellato, ... bioRxiv, 2021.05. 24.445390, 2021 | | 2021 |
Blocking tetanus with purified human monoclonal antibodies M Pirazzini, S Barbieri, A Grinzato, O Leka, F Vallese, G Zanetti, ... Toxicon 190, S60-S60, 2021 | | 2021 |
Hsp90, thioredoxin and thioredoxin reductase form a chaperone-redox machinery enabling the catalytic activity of clostridial neurotoxins inside nerve terminals M Pirazzini, DA Tehran, G Zanetti, O Leka, A Mattarei, T Binz, R Lista, ... JOURNAL OF NEUROCHEMISTRY 142, 217-217, 2017 | | 2017 |
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals. M Pirazzini, O Leka, A Mattarei, F Lista, T Binz, O Rossetto, C Montecucco Cellular Microbiology 19 (2), 2016 | | 2016 |
Structural and functional characterization of AB toxins: diphtheria toxin and clostridial neurotoxins O Leka Università degli studi di Padova, 2016 | | 2016 |
169. A WEISSELLA ORYZAE BOTULINUM-LIKE TOXIN CLEAVES VAMP WITHIN THE JUXTAMEMBRANE DOMAIN C Montecucco, I Zornetta, G Arrigoni, F Anniballi, L Bano, O Leka, ... Abstracts/Toxicon 123 (S2eS90), S2eS90, 2016 | | 2016 |
Hsp90, thioredoxin, and thioredoxin reductase form a chaperone-redox machinery enabling the catalytic activity of clostridial neurotoxins inside nerve terminals M Pirazzini, G Zanetti, O Leka, T Binz, F Lista, A Mattarei, O Rossetto, ... Toxicon, S68, 2016 | | 2016 |