Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids F Grein, A Müller, KM Scherer, X Liu, KC Ludwig, A Klöckner, M Strach, ... Nature communications 11 (1), 1455, 2020 | 173 | 2020 |
Host defense peptides: Dual antimicrobial and immunomodulatory action M Drayton, JP Deisinger, KC Ludwig, N Raheem, A Müller, T Schneider, ... International Journal of Molecular Sciences 22 (20), 11172, 2021 | 62 | 2021 |
The lasso peptide siamycin-I targets lipid II at the Gram-positive cell surface S Tan, KC Ludwig, A Müller, T Schneider, JR Nodwell ACS Chemical Biology 14 (5), 966-974, 2019 | 39 | 2019 |
An antibiotic from an uncultured bacterium binds to an immutable target R Shukla, AJ Peoples, KC Ludwig, S Maity, MGN Derks, S De Benedetti, ... Cell 186 (19), 4059-4073. e27, 2023 | 23 | 2023 |
Biosynthesis and mechanism of action of the cell wall targeting antibiotic hypeptin DA Wirtz, KC Ludwig, M Arts, CE Marx, S Krannich, P Barac, S Kehraus, ... Angewandte Chemie International Edition 60 (24), 13579-13586, 2021 | 22 | 2021 |
Steroids originating from bacterial bile acid degradation affect Caenorhabditis elegans and indicate potential risks for the fauna of manured soils MN Mendelski, R Dölling, FM Feller, D Hoffmann, L Ramos Fangmeier, ... Scientific Reports 9 (1), 11120, 2019 | 18 | 2019 |
A novel steroid-coenzyme A ligase from Novosphingobium sp. strain Chol11 is essential for an alternative degradation pathway for bile salts O Yücel, J Holert, KC Ludwig, S Thierbach, B Philipp Applied and Environmental Microbiology 84 (1), e01492-17, 2018 | 11 | 2018 |
THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates E Reithuber, T Wixe, KC Ludwig, A Müller, H Uvell, F Grein, AEG Lindgren, ... Proceedings of the National Academy of Sciences 118 (47), e2108244118, 2021 | 7 | 2021 |
Ca (2+)-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids. Nat Commun 2020; 11: 1455 F Grein, A Müller, KM Scherer, X Liu, KC Ludwig, A Klöckner Epub 2020/03/21. doi: 10.1038/s41467-020-15257-1 32193379, 0 | 6 | |
Impacts of NaHCO3 on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO3-Responsive versus NaHCO3-Non-Responsive Phenotypes SC Ersoy, LC Chan, MR Yeaman, HF Chambers, RA Proctor, KC Ludwig, ... Antibiotics 11 (4), 462, 2022 | 5 | 2022 |
Investigations on the Degradation of the Bile Salt Cholate via the 9,10-Seco-Pathway Reveals the Formation of a Novel Recalcitrant Steroid Compound by a Side Reaction in … FM Feller, S Eilebrecht, R Nedielkov, O Yücel, J Alvincz, G Salinas, ... Microorganisms 9 (10), 2146, 2021 | 1 | 2021 |
An antibiotic from an uncultured bacterium binds to an immutable target K Nieselt, R Shukla, AJ Peoples, KC Ludwig, S Maity, MGN Derks, ... Cell 186 (19), 2023 | | 2023 |
A new antibiotic from an uncultured bacterium binds to an immutable target R Shukla, AJ Peoples, KC Ludwig, S Maity, MGN Derks, S de Benedetti, ... bioRxiv, 2023 | | 2023 |
Lipid II-binding antibiotics–differential antibiotic activities beyond sequestration of the central peptidoglycan precursor KC Ludwig Universitäts-und Landesbibliothek Bonn, 2023 | | 2023 |
THCz E Reithuber, T Wixe, KC Ludwig, A Müller, H Uvell, F Grein, AEG Lindgren, ... Proceedings of the National Academy of Sciences of the United States of …, 2021 | | 2021 |