| Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ... Journal of medicinal chemistry 52 (24), 7950-7953, 2009 | 246 | 2009 |
| Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines. F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ... Journal of medicinal chemistry 53 (15), 5844-5857, 2010 | 218 | 2010 |
| Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ... Nature Chemical Biology, 2013 | 188 | 2013 |
| Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines F Liu, D Barsyte-Lovejoy, A Allali-Hassani, Y He, M Herold, X Chen, ... Journal of medicinal chemistry, 2011 | 162 | 2011 |
| Small-molecule ligands of methyl-lysine binding proteins JM Herold, TJ Wigle, JL Norris, R Lam, VK Korboukh, C Gao, ... Journal of medicinal chemistry 54 (7), 2504-2511, 2011 | 136 | 2011 |
| Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins TJ Wigle, J Martin Herold, GA Senisterra, M Vedadi, DB Kireev, ... Journal of biomolecular screening 15 (1), 62-71, 2010 | 99 | 2010 |
| Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 A Ma, W Yu, F Li, RM Bleich, JM Herold, KV Butler, JL Norris, V Korboukh, ... Journal of medicinal chemistry 57 (15), 6822-6833, 2014 | 94 | 2014 |
| Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3 LI James, VK Korboukh, L Krichevsky, BM Baughman, JM Herold, ... Journal of medicinal chemistry 56 (18), 7358-7371, 2013 | 80 | 2013 |
| Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds D Kireev, TJ Wigle, J Norris-Drouin, JM Herold, WP Janzen, SV Frye Journal of medicinal chemistry 53 (21), 7625-7631, 2010 | 58 | 2010 |
| Small molecule IL-36γ antagonist as a novel therapeutic approach for plaque psoriasis V Todorović, Z Su, CB Putman, SJ Kakavas, KM Salte, HA McDonald, ... Scientific reports 9 (1), 9089, 2019 | 47 | 2019 |
| Structure–activity relationships of methyl-lysine reader antagonists JM Herold, LI James, VK Korboukh, C Gao, KE Coil, DJ Bua, JL Norris, ... MedChemComm 3 (1), 45-51, 2012 | 44 | 2012 |
| Suppl 1: Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins JM Herold, LA Ingerman, C Gao, SV Frye Current chemical genomics 5, 51, 2011 | 42 | 2011 |
| Biophysical probes reveal a “compromise” nature of the methyl-lysine binding pocket in L3MBTL1 C Gao, JM Herold, D Kireev, T Wigle, JL Norris, S Frye Journal of the American Chemical Society 133 (14), 5357-5362, 2011 | 39 | 2011 |
| Primary carboxamides as BTK inhibitors D Bonafoux, HM Davis, KE Frank, MM Friedman, JM Herold, ... US Patent 9,567,339, 2017 | 33 | 2017 |
| Palladium-and copper-catalyzed 1, 4-additions of organozinc compounds to conjugated aldehydes JA Marshall, M Herold, HS Eidam, P Eidam Organic Letters 8 (24), 5505-5508, 2006 | 30 | 2006 |
| Heterocyclic kinase inhibitors MM Friedman, P Cox, KE Frank, MZ Hoemann, A Osuma, NS Wilson, ... US Patent 10,280,184, 2019 | 20 | 2019 |
| Assessment of free energy predictors for ligand binding to a methyllysine histone code reader C Gao, JM Herold, D Kireev Journal of Computational Chemistry 33 (6), 659-665, 2012 | 8 | 2012 |
| Primary carboxamides as btk inhibitors D Bonafoux, HM Davis, KE Frank, MM Friedman, JM Herold, ... | 3 | 2019 |
| Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712 E Breinlinger, S Van Epps, M Friedman, M Argiriadi, E Chien, G Chhor, ... Journal of Medicinal Chemistry 66 (20), 14335-14356, 2023 | 1 | 2023 |
| Identification of potent and selective inhibitors of PKR via virtual screening and traditional design KP Cusack, MA Argiriadi, TD Gordon, CM Harris, JM Herold, ... Bioorganic & Medicinal Chemistry Letters 79, 129047, 2023 | 1 | 2023 |
