Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS L Banci, I Bertini, A Durazo, S Girotto, EB Gralla, M Martinelli, JS Valentine, ... Proceedings of the National Academy of Sciences 104 (27), 11263-11267, 2007 | 279 | 2007 |
SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization L Banci, I Bertini, M Boca, S Girotto, M Martinelli, JS Valentine, M Vieru PloS one 3 (2), e1677, 2008 | 256 | 2008 |
Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants L Banci, I Bertini, M Boca, V Calderone, F Cantini, S Girotto, M Vieru Proceedings of the National Academy of Sciences 106 (17), 6980-6985, 2009 | 142 | 2009 |
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function N Plotegher, G Berti, E Ferrari, I Tessari, M Zanetti, L Lunelli, E Greggio, ... Scientific reports 7 (1), 40699, 2017 | 130 | 2017 |
Reduced affinity for isoniazid in the S315T mutant ofMycobacterium tuberculosis KatG is a key factor in antibiotic resistance S Yu, S Girotto, C Lee, RS Magliozzo Journal of Biological Chemistry 278 (17), 14769-14775, 2003 | 128 | 2003 |
DJ-1 is a copper chaperone acting on SOD1 activation S Girotto, L Cendron, M Bisaglia, I Tessari, S Mammi, G Zanotti, ... Journal of Biological Chemistry 289 (15), 10887-10899, 2014 | 103 | 2014 |
Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53 S Girotto, M Sturlese, M Bellanda, I Tessari, R Cappellini, M Bisaglia, ... Journal of Biological Chemistry 287 (22), 18738-18749, 2012 | 87 | 2012 |
Identification and Characterization of Tyrosyl Radical Formation in Mycobacterium tuberculosisCatalase-Peroxidase (KatG) S Chouchane, S Girotto, S Yu, RS Magliozzo Journal of Biological Chemistry 277 (45), 42633-42638, 2002 | 84 | 2002 |
Rapid formation of compound II and a tyrosyl radical in the Y229F mutant of Mycobacterium tuberculosis catalase-peroxidase disrupts catalase but not peroxidase function S Yu, S Girotto, X Zhao, RS Magliozzo Journal of Biological Chemistry 278 (45), 44121-44127, 2003 | 73 | 2003 |
Analysis of heme structural heterogeneity in Mycobacterium tuberculosis catalase-peroxidase (KatG) S Chouchane, S Girotto, S Kapetanaki, JPM Schelvis, S Yu, RS Magliozzo Journal of Biological Chemistry 278 (10), 8154-8162, 2003 | 61 | 2003 |
Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase D Pizzirani, A Bach, N Realini, A Armirotti, L Mengatto, I Bauer, S Girotto, ... Angewandte Chemie 127 (2), 495-499, 2015 | 45 | 2015 |
Keys to lipid selection in fatty acid amide hydrolase catalysis: structural flexibility, gating residues and multiple binding pockets G Palermo, I Bauer, P Campomanes, A Cavalli, A Armirotti, S Girotto, ... PLoS computational biology 11 (6), e1004231, 2015 | 44 | 2015 |
Evidence for radical formation at Tyr-353 in Mycobacterium tuberculosis catalase-peroxidase (KatG) X Zhao, S Girotto, S Yu, RS Magliozzo Journal of Biological Chemistry 279 (9), 7606-7612, 2004 | 43 | 2004 |
Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy S Kapetanaki, S Chouchane, S Girotto, S Yu, RS Magliozzo, JPM Schelvis Biochemistry 42 (13), 3835-3845, 2003 | 40 | 2003 |
Investigating drug–target residence time in kinases through enhanced sampling simulations D Gobbo, V Piretti, RMC Di Martino, SK Tripathi, B Giabbai, P Storici, ... Journal of Chemical Theory and Computation 15 (8), 4646-4659, 2019 | 38 | 2019 |
Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells M Roberti, F Schipani, G Bagnolini, D Milano, E Giacomini, F Falchi, ... European Journal of Medicinal Chemistry 165, 80-92, 2019 | 38 | 2019 |
Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib G Bagnolini, D Milano, M Manerba, F Schipani, JA Ortega, D Gioia, ... Journal of Medicinal Chemistry 63 (5), 2588-2619, 2020 | 33 | 2020 |
Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer … K Ranguelova, S Girotto, GJ Gerfen, S Yu, J Suarez, L Metlitsky, ... Journal of biological chemistry 282 (9), 6255-6264, 2007 | 33 | 2007 |
NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells N Plotegher, C Stringari, S Jahid, M Veronesi, S Girotto, E Gratton, ... The FASEB Journal 29 (6), 2484, 2015 | 32 | 2015 |
Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis E Ferrari, M Engelen, E Monzani, M Sturini, S Girotto, L Bubacco, L Zecca, ... JBIC Journal of Biological Inorganic Chemistry 18, 81-93, 2013 | 29 | 2013 |