Joseph Edward Chambers
Joseph Edward Chambers
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Endoplasmic Reticulum Stress in Malignancy
HJ Clarke, JE Chambers, E Liniker, SJ Marciniak
Cancer Cell 25 (5), 563-573, 2014
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
P van Galen, A Kreso, N Mbong, DG Kent, T Fitzmaurice, JE Chambers, ...
Nature, 2014
Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin
CE Jessop, TJ Tavender, RH Watkins, JE Chambers, NJ Bulleid
Journal of Biological Chemistry 284 (4), 2194-2202, 2009
ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load
JE Chambers, K Petrova, G Tomba, M Vendruscolo, D Ron
The Journal of Cell Biology 198 (3), 371-385, 2012
The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1α
JE Chambers, TJ Tavender, OBV Oka, S Warwood, D Knight, NJ Bulleid
Journal of Biological Chemistry 285 (38), 29200-29207, 2010
Protein misfolding and ER stress
JE Chambers, SJ Marciniak
American Journal of Physiology-Cell Physiology, 2014
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
A Crespillo-Casado, JE Chambers, PM Fischer, SJ Marciniak, D Ron
eLife 6, e26109, 2017
An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles.
JE Chambers, M Kubankova, RG Huber, I López-Duarte, E Avezov, ...
ACS nano, 2018
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation
JE Chambers, LE Dalton, HJ Clarke, E Malzer, CS Dominicus, V Patel, ...
eLife, e04872, 2015
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker
S Preissler, JE Chambers, A Crespillo-Casado, E Avezov, E Miranda, ...
eLife, 2015
Single particle trajectories reveal active endoplasmic reticulum luminal flow
D Holcman, P Parutto, JE Chambers, M Fantham, LJ Young, SJ Marciniak, ...
Nature Cell Biology, 1, 2018
Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly
JE Chambers, CE Jessop, NJ Bulleid
Journal of Biological Chemistry 283 (4), 1862-1869, 2008
New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms
SJ Marciniak, A Ordóńez, JA Dickens, JE Chambers, V Patel, ...
Annals of the American Thoracic Society 13 (Supplement 4), S289-S296, 2016
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin
JA Dickens, A Ordóńez, JE Chambers, AJ Beckett, V Patel, E Malzer, ...
The FASEB Journal, fj. 201600430R, 2016
HaloFlippers: A General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension Changes in Living Cells
K Straková, J López-Andarias, N Jiménez-Rojo, JE Chambers, ...
ACS Central Science, 2020
The integrated stress response regulates BMP signalling through effects on translation
E Malzer, CS Dominicus, JE Chambers, JA Dickens, S Mookerjee, ...
BMC biology 16 (1), 34, 2018
Spontaneous pneumothorax can be associated with TGFBR2 mutation
JE Chambers, LE Dalton, DN Subramanian, B Gooptu, A Balan, S Park, ...
European Respiratory Society, 2015
Linker length affects photostability of protein-targeted sensor of cellular microviscosity
M Kubankova, J Chambers, R Huber, P Bond, S Marciniak, M Kuimova
Methods and applications in fluorescence, 2019
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice
V Patel, G Bidault, JE Chambers, S Carobbio, AJT Everden, C Garces, ...
Scientific Reports 9 (1), 2903, 2019
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum
T Konno, EP Melo, JE Chambers, E Avezov
Cells 10 (2), 233, 2021
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