| Endoplasmic Reticulum Stress in Malignancy HJ Clarke, JE Chambers, E Liniker, SJ Marciniak Cancer Cell 25 (5), 563-573, 2014 | 465 | 2014 |
| The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress P van Galen, A Kreso, N Mbong, DG Kent, T Fitzmaurice, JE Chambers, ... Nature, 2014 | 366 | 2014 |
| Pharmacological targeting of endoplasmic reticulum stress in disease SJ Marciniak, JE Chambers, D Ron Nature Reviews Drug Discovery, 1-26, 2021 | 198 | 2021 |
| An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. JE Chambers, M Kubankova, RG Huber, I López-Duarte, E Avezov, ... ACS nano, 2018 | 133 | 2018 |
| Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin CE Jessop, TJ Tavender, RH Watkins, JE Chambers, NJ Bulleid Journal of Biological Chemistry 284 (4), 2194-2202, 2009 | 108 | 2009 |
| PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz A Crespillo-Casado, JE Chambers, PM Fischer, SJ Marciniak, D Ron eLife 6, e26109, 2017 | 99 | 2017 |
| ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load JE Chambers, K Petrova, G Tomba, M Vendruscolo, D Ron The Journal of Cell Biology 198 (3), 371-385, 2012 | 99 | 2012 |
| Protein misfolding and ER stress JE Chambers, SJ Marciniak American Journal of Physiology-Cell Physiology, 2014 | 94 | 2014 |
| The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1α JE Chambers, TJ Tavender, OBV Oka, S Warwood, D Knight, NJ Bulleid Journal of Biological Chemistry 285 (38), 29200-29207, 2010 | 88 | 2010 |
| Single particle trajectories reveal active endoplasmic reticulum luminal flow D Holcman, P Parutto, JE Chambers, M Fantham, LJ Young, SJ Marciniak, ... Nature Cell Biology, 1, 2018 | 86 | 2018 |
| Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation JE Chambers, LE Dalton, HJ Clarke, E Malzer, CS Dominicus, V Patel, ... eLife, e04872, 2015 | 82 | 2015 |
| Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker S Preissler, JE Chambers, A Crespillo-Casado, E Avezov, E Miranda, ... eLife, 2015 | 75 | 2015 |
| Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum T Konno, EP Melo, JE Chambers, E Avezov Cells 10 (2), 233, 2021 | 65 | 2021 |
| HaloFlippers: A General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension Changes in Living Cells K Straková, J López-Andarias, N Jiménez-Rojo, JE Chambers, ... ACS Central Science, 2020 | 45 | 2020 |
| Pulmonary endoplasmic reticulum stress—scars, smoke, and suffocation JA Dickens, E Malzer, JE Chambers, SJ Marciniak The FEBS journal 286 (2), 322-341, 2019 | 30 | 2019 |
| The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin JA Dickens, A Ordóñez, JE Chambers, AJ Beckett, V Patel, E Malzer, ... The FASEB Journal, fj. 201600430R, 2016 | 27 | 2016 |
| New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms SJ Marciniak, A Ordóñez, JA Dickens, JE Chambers, V Patel, ... Annals of the American Thoracic Society 13 (Supplement 4), S289-S296, 2016 | 26 | 2016 |
| Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly JE Chambers, CE Jessop, NJ Bulleid Journal of Biological Chemistry 283 (4), 1862-1869, 2008 | 25 | 2008 |
| The integrated stress response regulates BMP signalling through effects on translation E Malzer, CS Dominicus, JE Chambers, JA Dickens, S Mookerjee, ... BMC biology 16 (1), 34, 2018 | 21 | 2018 |
| Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state JE Chambers, N Zubkov, M Kubánková, J Nixon-Abell, I Mela, S Abreu, ... Science Advances 8 (14), eabm2094, 2022 | 14 | 2022 |
Stefan MarciniakProfessor of Respiratory Science, CambridgeVerified email at cam.ac.uk
