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Nicolas Lehrbach
Nicolas Lehrbach
Assistant Professor, Basic Sciences, Fred Hutchinson Cancer Research Center
Verified email at fredhutch.org - Homepage
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Cited by
Year
piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
A Ashe, A Sapetschnig, EM Weick, J Mitchell, MP Bagijn, AC Cording, ...
Cell 150 (1), 88-99, 2012
8012012
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline
PP Das, MP Bagijn, LD Goldstein, JR Woolford, NJ Lehrbach, ...
Molecular cell 31 (1), 79-90, 2008
4852008
Function, targets, and evolution of Caenorhabditis elegans piRNAs
MP Bagijn, LD Goldstein, A Sapetschnig, EM Weick, S Bouasker, ...
Science 337 (6094), 574-578, 2012
3982012
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
NJ Lehrbach, J Armisen, HL Lightfoot, KJ Murfitt, A Bugaut, ...
Nature structural & molecular biology 16 (10), 1016-1020, 2009
2932009
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
NJ Lehrbach, G Ruvkun
elife 5, e17721, 2016
2162016
A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
A Ashe, T Bélicard, J Le Pen, P Sarkies, L Frézal, NJ Lehrbach, MA Félix, ...
elife 2, e00994, 2013
1672013
Tertiary siRNAs Mediate Paramutation in C. elegans
A Sapetschnig, P Sarkies, NJ Lehrbach, EA Miska
PLoS Genetics 11 (3), e1005078, 2015
1162015
Complex patterns of transcription at the insertion site of a retrotransposon in the mouse
R Druker, TJ Bruxner, NJ Lehrbach, E Whitelaw
Nucleic acids research 32 (19), 5800-5808, 2004
1142004
Protein sequence editing of SKN-1A/Nrf1 by peptide: N-glycanase controls proteasome gene expression
NJ Lehrbach, PC Breen, G Ruvkun
Cell 177 (3), 737-750. e15, 2019
1012019
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans
M Jovanovic, L Reiter, P Picotti, V Lange, E Bogan, B A Hurschler, ...
Nature methods 7 (10), 837-842, 2010
972010
The Conserved miR-51 microRNA Family Is Redundantly Required for Embryonic Development and Pharynx Attachment in Caenorhabditis elegans
WR Shaw, J Armisen, NJ Lehrbach, EA Miska
Genetics 185 (3), 897-905, 2010
762010
Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans
NJ Lehrbach, C Castro, KJ Murfitt, C Abreu-Goodger, JL Griffin, EA Miska
Rna 18 (12), 2220-2235, 2012
622012
Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
NJ Lehrbach, G Ruvkun
Elife 8, e44425, 2019
582019
A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing
HL Lightfoot, A Bugaut, J Armisen, NJ Lehrbach, EA Miska, ...
Biochemistry 50 (35), 7514-7521, 2011
512011
A study of Caenorhabditis elegans DAF-2 mutants by metabolomics and differential correlation networks
C Castro, J Krumsiek, NJ Lehrbach, SA Murfitt, EA Miska, JL Griffin
Molecular BioSystems 9 (7), 1632-1642, 2013
472013
RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans
A Akay, A Craig, N Lehrbach, M Larance, E Pourkarimi, JE Wright, ...
Open biology 3 (11), 130151, 2013
292013
Next‐Generation Sequencing for Identification of EMS‐Induced Mutations in Caenorhabditis elegans
NJ Lehrbach, F Ji, R Sadreyev
Current protocols in molecular biology 117 (1), 7.29. 1-7.29. 12, 2017
252017
Regulation of pre-miRNA Processing
NJ Lehrbach, EA Miska
Adv Exp Med Biol 700 (4), 67-75, 2010
232010
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
AG Charlesworth, U Seroussi, NJ Lehrbach, MS Renaud, AE Sundby, ...
Nucleic Acids Research 49 (15), 8836-8865, 2021
222021
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans
EJ Tillman, CE Richardson, DJ Cattie, KC Reddy, NJ Lehrbach, R Droste, ...
Genetics 210 (4), 1329-1337, 2018
202018
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