| Autoregulation of Parkin activity through its ubiquitin‐like domain VK Chaugule, L Burchell, KR Barber, A Sidhu, SJ Leslie, GS Shaw, ... The EMBO journal 30 (14), 2853-2867, 2011 | 360 | 2011 |
| Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ... The EMBO journal 34 (20), 2506-2521, 2015 | 185 | 2015 |
| A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly N Eisenhardt, VK Chaugule, S Koidl, M Droescher, E Dogan, J Rettich, ... Nature structural & molecular biology 22 (12), 959-967, 2015 | 109 | 2015 |
| Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity A Kumar, VK Chaugule, TEC Condos, KR Barber, C Johnson, R Toth, ... Nature structural & molecular biology 24 (5), 475-483, 2017 | 100 | 2017 |
| Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae H Klug, M Xaver, VK Chaugule, S Koidl, G Mittler, F Klein, A Pichler Molecular cell 50 (5), 625-636, 2013 | 88 | 2013 |
| Specificity and disease in the ubiquitin system VK Chaugule, H Walden Biochemical Society Transactions 44 (1), 212-227, 2016 | 67 | 2016 |
| Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 AF Alpi, V Chaugule, H Walden Biochemical Journal 473 (20), 3401-3419, 2016 | 65 | 2016 |
| SUMO rules: regulatory concepts and their implication in neurologic functions M Droescher, VK Chaugule, A Pichler Neuromolecular medicine 15, 639-660, 2013 | 57 | 2013 |
| Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation L Burchell, VK Chaugule, H Walden PloS one 7 (4), e34748, 2012 | 46 | 2012 |
| Synergistic recruitment of UbcH7~ Ub and phosphorylated Ubl domain triggers parkin activation TEC Condos, KM Dunkerley, EA Freeman, KR Barber, JD Aguirre, ... The EMBO journal 37 (23), e100014, 2018 | 38 | 2018 |
| RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation F Bustos, A Segarra-Fas, VK Chaugule, L Brandenburg, E Branigan, ... Cell reports 23 (6), 1599-1611, 2018 | 37 | 2018 |
| DHX15 regulates CMTR1-dependent gene expression and cell proliferation F Inesta-Vaquera, VK Chaugule, A Galloway, L Chandler, ... Life science alliance 1 (3), 2018 | 36 | 2018 |
| Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening FE Morreale, A Bortoluzzi, VK Chaugule, C Arkinson, H Walden, A Ciulli Journal of medicinal chemistry 60 (9), 4093-4098, 2017 | 35 | 2017 |
| The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability S Koidl, N Eisenhardt, C Fatouros, M Droescher, VK Chaugule, A Pichler The international journal of biochemistry & cell biology 79, 478-487, 2016 | 33 | 2016 |
| Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA ML Rennie, K Lemonidis, C Arkinson, VK Chaugule, M Clarke, J Streetley, ... EMBO reports 21 (7), e50133, 2020 | 32 | 2020 |
| The Fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL JA Miles, MG Frost, E Carroll, ML Rowe, MJ Howard, A Sidhu, ... Journal of Biological Chemistry 290 (34), 20995-21006, 2015 | 27 | 2015 |
| Structural basis of FANCD2 deubiquitination by USP1− UAF1 ML Rennie, C Arkinson, VK Chaugule, R Toth, H Walden Nature Structural & Molecular Biology 28 (4), 356-364, 2021 | 26 | 2021 |
| Modes of allosteric regulation of the ubiquitination machinery ML Rennie, VK Chaugule, H Walden Current Opinion in Structural Biology 62, 189-196, 2020 | 26 | 2020 |
| Allosteric mechanism for site-specific ubiquitination of FANCD2 VK Chaugule, C Arkinson, ML Rennie, O Kämäräinen, R Toth, H Walden Nature Chemical Biology 16 (3), 291-301, 2020 | 26* | 2020 |
| Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements FE Morreale, A Testa, VK Chaugule, A Bortoluzzi, A Ciulli, H Walden Journal of medicinal chemistry 60 (19), 8183-8191, 2017 | 23 | 2017 |
Helen WaldenUniversity of GlasgowEmail verificata su glasgow.ac.uk
