Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines Y Lu, JP Welsh, JR Swartz Proceedings of the National Academy of Sciences 111 (1), 125-130, 2014 | 244 | 2014 |
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening M Bailly, C Mieczkowski, V Juan, E Metwally, D Tomazela, J Baker, ... Mabs 12 (1), 1743053, 2020 | 145 | 2020 |
Multiply mutated Gaussia luciferases provide prolonged and intense bioluminescence JP Welsh, KG Patel, K Manthiram, JR Swartz Biochemical and biophysical research communications 389 (4), 563-568, 2009 | 103 | 2009 |
A practical strategy for using miniature chromatography columns in a standardized high‐throughput workflow for purification development of monoclonal antibodies JP Welsh, MG Petroff, P Rowicki, H Bao, T Linden, DJ Roush, JM Pollard Biotechnology progress 30 (3), 626-635, 2014 | 67 | 2014 |
Escherichia coli‐based cell free production of flagellin and ordered flagellin display on virus‐like particles Y Lu, JP Welsh, W Chan, JR Swartz Biotechnology and bioengineering 110 (8), 2073-2085, 2013 | 62 | 2013 |
Cell‐free production of trimeric influenza hemagglutinin head domain proteins as vaccine antigens JP Welsh, Y Lu, XS He, HB Greenberg, JR Swartz Biotechnology and bioengineering 109 (12), 2962-2969, 2012 | 44 | 2012 |
Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling SW Benner, JP Welsh, MA Rauscher, JM Pollard Journal of Chromatography A 1593, 54-62, 2019 | 40 | 2019 |
Comparing the functional properties of the Hsp70 chaperones, DnaK and BiP J Bonomo, JP Welsh, K Manthiram, JR Swartz Biophysical chemistry 149 (1-2), 58-66, 2010 | 33 | 2010 |
Toward in silico CMC: An industrial collaborative approach to model‐based process development D Roush, D Asthagiri, DK Babi, S Benner, C Bilodeau, G Carta, P Ernst, ... Biotechnology and Bioengineering 117 (12), 3986-4000, 2020 | 30 | 2020 |
High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody MG Petroff, H Bao, JP Welsh, M van Beuningen–de Vaan, JM Pollard, ... Biotechnology and bioengineering 113 (6), 1273-1283, 2016 | 23 | 2016 |
Localization of BiP to translating ribosomes increases soluble accumulation of secreted eukaryotic proteins in an Escherichia coli cell‐free system JP Welsh, J Bonomo, JR Swartz Biotechnology and bioengineering 108 (8), 1739-1748, 2011 | 20 | 2011 |
Opportunities and challenges for model utilization in the biopharmaceutical industry: current versus future state DK Babi, J Griesbach, S Hunt, F Insaidoo, D Roush, R Todd, A Staby, ... Current Opinion in Chemical Engineering 36, 100813, 2022 | 19 | 2022 |
High‐throughput techniques to evaluate the effect of ligand density for impurity separations with multimodal cation exchange resins JP Welsh, H Bao, K Barlow, JM Pollard, E Brekkan, KM Lacki, TO Linden, ... Engineering in Life Sciences 16 (2), 160-168, 2016 | 13 | 2016 |
Domain antibody downstream process optimization: High‐throughput strategy and analytical methods JP Welsh, MA Rauscher, H Bao, S Meissner, IK Han, TO Linden, ... Engineering in Life Sciences 16 (2), 133-142, 2016 | 12 | 2016 |
Highland Games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences J Coffman, B Marques, R Orozco, M Aswath, H Mohammad, ... Biotechnology and Bioengineering 117 (7), 2100-2115, 2020 | 10 | 2020 |
Solubility partner IF2 Domain I enables high yield synthesis of transducible transcription factors in Escherichia coli WC Yang, JP Welsh, J Lee, JP Cooke, JR Swartz Protein expression and purification 80 (1), 145-151, 2011 | 10 | 2011 |
Application of simplex‐based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing S Konstantinidis, JP Welsh, DJ Roush, A Velayudhan Biotechnology progress 32 (2), 404-419, 2016 | 9 | 2016 |
Pushing the limits of high-throughput chromatography process development: current state and future directions J Welsh Pharmaceutical Bioprocessing 3 (1), 1-3, 2015 | 9 | 2015 |
Demonstrating β-glucan clearance in CHO-and yeast-produced monoclonal antibodies during downstream purification processes F Wang, H Li, Z Chen, JP Welsh, D Richardson, JM Pollard, D Richardson, ... J Bioprocess Biotech 4 (185), 2, 2014 | 9 | 2014 |
Isotherm model discrimination for multimodal chromatography using mechanistic models derived from high-throughput batch isotherm data SH Altern, JP Welsh, JY Lyall, AJ Kocot, S Burgess, V Kumar, C Williams, ... Journal of Chromatography A 1693, 463878, 2023 | 7 | 2023 |