| 5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits C Denise, P Paoli, M Calvani, ML Taddei, E Giannoni, S Kopetz, ... Oncotarget 6 (39), 41706, 2015 | 139 | 2015 |
| Ras-dependent carbon metabolism and transformation in mouse fibroblasts F Chiaradonna, E Sacco, R Manzoni, M Giorgio, M Vanoni, L Alberghina Oncogene 25 (39), 5391-5404, 2006 | 138 | 2006 |
| Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma C Raggi, ML Taddei, E Sacco, N Navari, M Correnti, B Piombanti, ... Journal of hepatology 74 (6), 1373-1385, 2021 | 66 | 2021 |
| Natural Compounds in Cancer Prevention: Effects of Coffee Extracts and Their Main Polyphenolic Component, 5‐O‐Caffeoylquinic Acid, on Oncogenic Ras Proteins A Palmioli, C Ciaramelli, R Tisi, M Spinelli, G De Sanctis, E Sacco, ... Chemistry–An Asian Journal 12 (18), 2457-2466, 2017 | 57 | 2017 |
| First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand A Palmioli, E Sacco, S Abraham, CJ Thomas, A Di Domizio, L De Gioia, ... Bioorganic & medicinal chemistry letters 19 (15), 4217-4222, 2009 | 55 | 2009 |
| Systems metabolomics: From metabolomic snapshots to design principles C Damiani, D Gaglio, E Sacco, L Alberghina, M Vanoni Current opinion in biotechnology 63, 190-199, 2020 | 47 | 2020 |
| Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RasG13D A Palmioli, E Sacco, C Airoldi, F Di Nicolantonio, A D’Urzo, S Shirasawa, ... Biochemical and Biophysical Research Communications 386 (4), 593-597, 2009 | 46 | 2009 |
| Characterization and properties of dominant-negative mutants of the Ras-specific guanine nucleotide exchange factor CDC25Mm M Vanoni, R Bertini, E Sacco, L Fontanella, M Rieppi, S Colombo, ... Journal of Biological Chemistry 274 (51), 36656-36662, 1999 | 29 | 1999 |
| Comparative analysis of the molecular mechanisms controlling the initiation of chromosomal DNA replication in yeast and in mammalian cells E Sacco, MM Hasan, L Alberghina, M Vanoni Biotechnology advances 30 (1), 73-98, 2012 | 27 | 2012 |
| Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells E Sacco, D Metalli, M Spinelli, R Manzoni, M Samalikova, R Grandori, ... Biotechnology advances 30 (1), 233-243, 2012 | 25 | 2012 |
| A comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks MM Hasan, S Brocca, E Sacco, M Spinelli, E Papaleo, M Lambrughi, ... Frontiers in physiology 4, 57552, 2014 | 24 | 2014 |
| Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007–present) E Sacco, M Spinelli, M Vanoni Expert opinion on therapeutic patents 22 (11), 1263-1287, 2012 | 21 | 2012 |
| Binding properties and biological characterization of new sugar-derived Ras ligands E Sacco, SJ Abraham, A Palmioli, G Damore, A Bargna, E Mazzoleni, ... MedChemComm 2 (5), 396-401, 2011 | 21 | 2011 |
| Profiling and targeting of energy and redox metabolism in grade 2 bladder cancer cells with different invasiveness properties V Pasquale, G Ducci, G Campioni, A Ventrici, C Assalini, S Busti, ... Cells 9 (12), 2669, 2020 | 19 | 2020 |
| Tumor heterogeneity: preclinical models, emerging technologies, and future applications M Proietto, M Crippa, C Damiani, V Pasquale, E Sacco, M Vanoni, ... Frontiers in Oncology 13, 1164535, 2023 | 16 | 2023 |
| Acquired glucose sensitivity of k-ras transformed fibroblasts F Chiaradonna, C Magnani, E Sacco, R Manzoni, L Alberghina, M Vanoni Biochemical Society Transactions 33 (1), 297-299, 2005 | 16 | 2005 |
| Catalytic competence of the Ras–GEF domain of hSos1 requires intra-REM domain interactions mediated by Phenylalanine 577 E Sacco, D Metalli, S Busti, S Fantinato, A D’Urzo, V Mapelli, L Alberghina, ... FEBS letters 580 (27), 6322-6328, 2006 | 14 | 2006 |
| An optimized workflow for the analysis of metabolic fluxes in cancer spheroids using Seahorse technology G Campioni, V Pasquale, S Busti, G Ducci, E Sacco, M Vanoni Cells 11 (5), 866, 2022 | 13 | 2022 |
| RalGPS2 interacts with Akt and PDK1 promoting tunneling nanotubes formation in bladder cancer and kidney cells microenvironment A D’Aloia, E Arrigoni, B Costa, G Berruti, E Martegani, E Sacco, M Ceriani Cancers 13 (24), 6330, 2021 | 13 | 2021 |
| Natural products attenuating biosynthesis, processing, and activity of ras oncoproteins: state of the art and future perspectives R Tisi, V Gaponenko, M Vanoni, E Sacco Biomolecules 10 (11), 1535, 2020 | 12 | 2020 |
