| DNA topoisomerase II as the primary target of anti-tumor anthracyclines. F Zunino, G Capranico Anti-cancer drug design 5 (4), 307-317, 1990 | 292 | 1990 |
| Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development G Capranico, S Tinelli, CA Austin, ML Fisher, F Zunino Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1132 (1 …, 1992 | 285 | 1992 |
| Anthracyclines: selected new developments M Binaschi, M Bigioni, A Cipollone, C Rossi, C Goso, CA Maggi, ... Current Medicinal Chemistry-Anti-Cancer Agents 1 (2), 113-130, 2001 | 262 | 2001 |
| Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. C Jaxel, G Capranico, D Kerrigan, KW Kohn, Y Pommier Journal of Biological Chemistry 266 (30), 20418-20423, 1991 | 259 | 1991 |
| Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin G Capranico, KW Kohn, Y Pommier Nucleic acids research 18 (22), 6611-6619, 1990 | 257 | 1990 |
| In hepatocellular carcinoma miR‐519d is up‐regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2 F Fornari, M Milazzo, P Chieco, M Negrini, E Marasco, G Capranico, ... The Journal of pathology 227 (3), 275-285, 2012 | 221 | 2012 |
| Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity G Capranico, F Zunino, KW Kohn, Y Pommier Biochemistry 29 (2), 562-569, 1990 | 198 | 1990 |
| DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells A De Magis, SG Manzo, M Russo, J Marinello, R Morigi, O Sordet, ... Proceedings of the National Academy of Sciences 116 (3), 816-825, 2019 | 196 | 2019 |
| Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide Y Pommier, G Capranico, A Orr, KW Kohn Nucleic acids research 19 (21), 5973-5980, 1991 | 187 | 1991 |
| Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II. K Wassermann, J Markovits, C Jaxel, G Capranico, KW Kohn, Y Pommier Molecular pharmacology 38 (1), 38-45, 1990 | 181 | 1990 |
| Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression G Giaccone, AF Gazdar, H Beck, F Zunino, G Capranico Cancer research 52 (7), 1666-1674, 1992 | 174 | 1992 |
| DNA sequence selectivity of topoisomerases and topoisomerase poisons G Capranico, M Binaschi Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1400 (1-3 …, 1998 | 170 | 1998 |
| Anthracyclines as topoisomerase II poisons: from early studies to new perspectives J Marinello, M Delcuratolo, G Capranico International journal of molecular sciences 19 (11), 3480, 2018 | 164 | 2018 |
| Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors R Filosa, A Peduto, S Di Micco, P de Caprariis, M Festa, A Petrella, ... Bioorganic & Medicinal Chemistry 17 (1), 13-24, 2009 | 136 | 2009 |
| A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons G Capranico, M Binaschi, ME Borgnetto, F Zunino, M Palumbo Trends in Pharmacological Sciences 18 (4), 323-329, 1997 | 134 | 1997 |
| New developments in antitumor anthracyclines F Arcamone, F Animati, G Capranico, P Lombardi, G Pratesi, S Manzini, ... Pharmacology & therapeutics 76 (1-3), 117-124, 1997 | 130 | 1997 |
| Relationship between lethal effects and topoisomerase II-mediated double-stranded DNA breaks produced by anthracyclines with different sequence specificity M Binaschi, G Capranico, L Dal Bo, F Zunino Molecular pharmacology 51 (6), 1053-1059, 1997 | 126 | 1997 |
| DNA Topoisomerase I differentially modulates R-loops across the human genome SG Manzo, SR Hartono, LA Sanz, J Marinello, S De Biasi, A Cossarizza, ... Genome biology 19, 1-18, 2018 | 121 | 2018 |
| Characterization of novel antisense HIF-1α transcripts in human cancers D Bertozzi, R Iurlaro, O Sordet, J Marinello, N Zaffaroni, G Capranico Cell cycle 10 (18), 3189-3197, 2011 | 119 | 2011 |
| Topoisomerase poisoning activity of novel disaccharide anthracyclines F Guano, P Pourquier, S Tinelli, M Binaschi, M Bigioni, F Animati, ... Molecular Pharmacology 56 (1), 77-84, 1999 | 111 | 1999 |
