| The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids AJ Brown, SM Goldsworthy, AA Barnes, MM Eilert, L Tcheang, D Daniels, ... Journal of Biological Chemistry 278 (13), 11312-11319, 2003 | 2435 | 2003 |
| Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein–coupled receptors C Southern, JM Cook, Z Neetoo-Isseljee, DL Taylor, CA Kettleborough, ... Journal of biomolecular screening 18 (5), 599-609, 2013 | 208 | 2013 |
| Engineering a model cell for rational tuning of GPCR signaling WM Shaw, H Yamauchi, J Mead, GOF Gowers, DJ Bell, D Öling, ... Cell 177 (3), 782-796. e27, 2019 | 163 | 2019 |
| Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation JH White, M Chiano, M Wigglesworth, R Geske, J Riley, N White, S Hall, ... Human molecular genetics 17 (13), 1890-1903, 2008 | 82 | 2008 |
| Increasing the delivery of next generation therapeutics from high throughput screening libraries MJ Wigglesworth, DC Murray, CJ Blackett, M Kossenjans, JWM Nissink Current Opinion in Chemical Biology 26, 104-110, 2015 | 55 | 2015 |
| Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides RH Clare, C Bardelle, P Harper, WD Hong, U Börjesson, KL Johnston, ... Nature communications 10 (1), 11, 2019 | 54 | 2019 |
| Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ... Journal of Medicinal Chemistry 59 (24), 11120-11137, 2016 | 53 | 2016 |
| Understanding cytotoxicity and cytostaticity in a high-throughput screening collection LH Mervin, Q Cao, IP Barrett, MA Firth, D Murray, L McWilliams, ... ACS chemical biology 11 (11), 3007-3023, 2016 | 53 | 2016 |
| Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74 PS Miller, J Barwell, DR Poyner, MJ Wigglesworth, SL Garland, ... Biochemical and biophysical research communications 391 (1), 437-442, 2010 | 44 | 2010 |
| Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders M Gianotti, M Botta, S Brough, R Carletti, E Castiglioni, C Corti, M Dal-Cin, ... Journal of medicinal chemistry 53 (21), 7778-7795, 2010 | 26 | 2010 |
| High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern AM Gravagnuolo, L Faqih, C Cronshaw, J Wynn, P Klapper, ... EBioMedicine 70, 2021 | 25* | 2021 |
| Management of Chemical and Biological Samples for Screening Applications M Wigglesworth, T Wood John Wiley & Sons, 2012 | 25 | 2012 |
| CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells AJ Clark, N Mullooly, D Safitri, M Harris, T de Vries, ... Communications biology 4 (1), 776, 2021 | 22 | 2021 |
| Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders M Gianotti, C Corti, S Delle Fratte, R Di Fabio, CP Leslie, F Pavone, ... Bioorganic & medicinal chemistry letters 20 (17), 5069-5073, 2010 | 22 | 2010 |
| Innovation leading the way: application of lean manufacturing to sample management M Allen, MJ Wigglesworth Journal of biomolecular screening 14 (5), 515-522, 2009 | 22 | 2009 |
| Use of cryopreserved cells for enabling greater flexibility in compound profiling MJ Wigglesworth, KJ Lawless, DJ Standing, EK Mackenzie, VR Kitchen, ... Journal of biomolecular screening 13 (5), 354-362, 2008 | 20 | 2008 |
| Enabling 1536-well high-throughput cell-based screening through the application of novel centrifugal plate washing S Knight, H Plant, L McWilliams, D Murray, R Dixon-Steele, A Varghese, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (6), 732-742, 2017 | 18 | 2017 |
| Access to 3D Alicyclic Amine-Containing Fragments through Transannular C–H Arylation M Lee, A Adams, PB Cox, MS Sanford Synlett 30 (04), 417-422, 2019 | 17 | 2019 |
| The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor B Wroblowski, MJ Wigglesworth, PG Szekeres, GD Smith, SS Rahman, ... Journal of medicinal chemistry 52 (3), 818-825, 2009 | 17 | 2009 |
| A perspective on synthetic biology in drug discovery and development—current impact and future opportunities F David, AM Davis, M Gossing, MA Hayes, E Romero, LH Scott, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (5), 581-603, 2021 | 16 | 2021 |
Fiona MarshallPresident Biomedical Research NovartisVerified email at novartis.com
