| Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Y Zhao, P Gong, Y Chen, JC Nwachukwu, S Srinivasan, CM Ko, ... Science translational medicine 7 (271), 271ra9-271ra9, 2015 | 165 | 2015 |
| Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ... elife 3, e02057, 2014 | 142 | 2014 |
| Structural mechanism for signal transduction in RXR nuclear receptor heterodimers DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ... Nature communications 6 (1), 8013, 2015 | 133 | 2015 |
| Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells JD Stender, JC Nwachukwu, I Kastrati, Y Kim, T Strid, M Yakir, ... Molecular cell 65 (6), 1122-1135. e5, 2017 | 109 | 2017 |
| Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland OY Khan, G Fu, A Ismail, S Srinivasan, X Cao, Y Tu, S Lu, Z Nawaz Molecular endocrinology 20 (3), 544-559, 2006 | 101 | 2006 |
| Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α S Srinivasan, JC Nwachukwu, AA Parent, V Cavett, J Nowak, TS Hughes, ... Nature chemical biology 9 (5), 326-332, 2013 | 66 | 2013 |
| Thiophene-core estrogen receptor ligands having superagonist activity J Min, P Wang, S Srinivasan, JC Nwachukwu, P Guo, M Huang, ... Journal of medicinal chemistry 56 (8), 3346-3366, 2013 | 60 | 2013 |
| Full antagonism of the estrogen receptor without a prototypical ligand side chain S Srinivasan, JC Nwachukwu, NE Bruno, V Dharmarajan, D Goswami, ... Nature chemical biology 13 (1), 111-118, 2017 | 59 | 2017 |
| Predictive features of ligand‐specific signaling through the estrogen receptor JC Nwachukwu, S Srinivasan, Y Zheng, S Wang, J Min, C Dong, Z Liao, ... Molecular Systems Biology 12 (4), 864, 2016 | 47 | 2016 |
| Systems structural biology analysis of ligand effects on ERα predicts cellular response to environmental estrogens and anti-hormone therapies JC Nwachukwu, S Srinivasan, NE Bruno, J Nowak, NJ Wright, F Minutolo, ... Cell chemical biology 24 (1), 35-45, 2017 | 43 | 2017 |
| Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure–activity relationships of estrogen receptor ligands based on bridged oxabicyclic … M Zhu, C Zhang, JC Nwachukwu, S Srinivasan, V Cavett, Y Zheng, ... Organic & biomolecular chemistry 10 (43), 8692-8700, 2012 | 41 | 2012 |
| E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth S Srinivasan, Z Nawaz Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1809 (2), 119-127, 2011 | 40 | 2011 |
| GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 MR Mahamud, X Geng, YC Ho, B Cha, Y Kim, J Ma, L Chen, G Myers, ... Development 146 (21), dev184218, 2019 | 39 | 2019 |
| ERα, SKP2 and E2F-1 form a feed forward loop driving late ERα targets and G1 cell cycle progression W Zhou, S Srinivasan, Z Nawaz, JM Slingerland Oncogene 33 (18), 2341-2353, 2014 | 37 | 2014 |
| Development of selective estrogen receptor modulator (SERM)‐like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7 … Y Zheng, M Zhu, S Srinivasan, JC Nwachukwu, V Cavett, J Min, ... ChemMedChem 7 (6), 1094-1100, 2012 | 33 | 2012 |
| Adamantyl antiestrogens with novel side chains reveal a spectrum of activities in suppressing estrogen receptor mediated activities in breast cancer cells J Min, VS Guillen, A Sharma, Y Zhao, Y Ziegler, P Gong, CG Mayne, ... Journal of medicinal chemistry 60 (14), 6321-6336, 2017 | 29 | 2017 |
| Dual-mechanism estrogen receptor inhibitors J Min, JC Nwachukwu, CK Min, JW Njeri, S Srinivasan, ES Rangarajan, ... Proceedings of the National Academy of Sciences 118 (35), e2101657118, 2021 | 26 | 2021 |
| Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor ZQ Liao, C Dong, KE Carlson, S Srinivasan, JC Nwachukwu, RW Chesnut, ... Journal of medicinal chemistry 57 (8), 3532-3545, 2014 | 26 | 2014 |
| A new CIS curriculum design approach for the 21st century S Srinivasan, J Guan, AL Wright Journal of Computer Information Systems 39 (3), 99-106, 1999 | 24 | 1999 |
| LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus Q Zhou, B Yu, C Anderson, ZP Huang, J Hanus, W Zhang, Y Han, ... Elife 8, e40470, 2019 | 21 | 2019 |
