Paolo Puccetti
Paolo Puccetti
Professor of Pharmacology
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Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
T Zelante, RG Iannitti, C Cunha, A De Luca, G Giovannini, G Pieraccini, ...
Immunity 39 (2), 372-385, 2013
Modulation of tryptophan catabolism by regulatory T cells
F Fallarino, U Grohmann, KW Hwang, C Orabona, C Vacca, R Bianchi, ...
Nature immunology 4 (12), 1206-1212, 2003
CTLA-4–Ig regulates tryptophan catabolism in vivo
U Grohmann, C Orabona, F Fallarino, C Vacca, F Calcinaro, A Falorni, ...
Nature immunology 3 (11), 1097-1101, 2002
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells
F Fallarino, U Grohmann, S You, BC McGrath, DR Cavener, C Vacca, ...
The Journal of Immunology 176 (11), 6752-6761, 2006
T cell apoptosis by tryptophan catabolism
F Fallarino, U Grohmann, C Vacca, R Bianchi, C Orabona, A Spreca, ...
Cell Death & Differentiation 9 (10), 1069-1077, 2002
Tolerance, DCs and tryptophan: much ado about IDO
U Grohmann, F Fallarino, P Puccetti
Trends in immunology 24 (5), 242-248, 2003
Indoleamine 2, 3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
MT Pallotta, C Orabona, C Volpi, C Vacca, ML Belladonna, R Bianchi, ...
Nature immunology 12 (9), 870-878, 2011
Natural killer cells: characteristics and regulation of activity
RB Herberman, JY Djeu, HD Kay, JR Ortaldo, C Riccardi, GD Bonnard, ...
Immunological reviews 44, 43-70, 1979
IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
T Zelante, A De Luca, P Bonifazi, C Montagnoli, S Bozza, S Moretti, ...
European journal of immunology 37 (10), 2695-2706, 2007
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
A Bessede, M Gargaro, MT Pallotta, D Matino, G Servillo, C Brunacci, ...
Nature 511 (7508), 184-190, 2014
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
L Romani, F Fallarino, A De Luca, C Montagnoli, C D’Angelo, T Zelante, ...
Nature 451 (7175), 211-215, 2008
IL-23 and Th17 cells enhance Th2-cell–mediated eosinophilic airway inflammation in mice
H Wakashin, K Hirose, Y Maezawa, S Kagami, A Suto, N Watanabe, ...
American journal of respiratory and critical care medicine 178 (10), 1023-1032, 2008
IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation
P Puccetti, U Grohmann
Nature Reviews Immunology 7 (10), 817-823, 2007
Gut CD103+ dendritic cells express indoleamine 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
G Matteoli, E Mazzini, ID Iliev, E Mileti, F Fallarino, P Puccetti, M Chieppa, ...
Gut 59 (5), 595-604, 2010
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
C Orabona, U Grohmann, ML Belladonna, F Fallarino, C Vacca, R Bianchi, ...
Nature immunology 5 (11), 1134-1142, 2004
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
U Grohmann, C Volpi, F Fallarino, S Bozza, R Bianchi, C Vacca, ...
Nature medicine 13 (5), 579-586, 2007
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.
L Romani, A Mencacci, E Cenci, R Spaccapelo, C Toniatti, P Puccetti, ...
The Journal of experimental medicine 183 (4), 1345-1355, 1996
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
ML Belladonna, JC Renauld, R Bianchi, C Vacca, F Fallarino, C Orabona, ...
The Journal of Immunology 168 (11), 5448-5454, 2002
IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production
U Grohmann, ML Belladonna, R Bianchi, C Orabona, E Ayroldi, ...
Immunity 9 (3), 315-323, 1998
Interleukin‐4 and interleukin‐10 inhibit nitric oxide‐dependent macrophage killing of Candida albicans
E Cenci, L Romani, A Mencacci, R Spaccapelo, E Schiaffella, P Puccetti, ...
European journal of immunology 23 (5), 1034-1038, 1993
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