Inhibition of Small-Conductance Ca2+-Activated K+ Channels Terminates and Protects Against Atrial Fibrillation JG Diness, US Sørensen, JD Nissen, B Al-Shahib, T Jespersen, ... Circulation: Arrhythmia and electrophysiology 3 (4), 380-390, 2010 | 208 | 2010 |
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria L Skibsbye, C Poulet, JG Diness, BH Bentzen, L Yuan, U Kappert, ... Cardiovascular research 103 (1), 156-167, 2014 | 199 | 2014 |
Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog XY Qi, JG Diness, BJJM Brundel, XB Zhou, P Naud, CT Wu, H Huang, ... Circulation 129 (4), 430-440, 2014 | 191 | 2014 |
Effects on Atrial Fibrillation in Aged Hypertensive Rats by Ca2+-Activated K+ Channel Inhibition JG Diness, L Skibsbye, T Jespersen, ED Bartels, US Sørensen, ... Hypertension 57 (6), 1129-1135, 2011 | 116 | 2011 |
The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca2+-activated K+ channels L Skibsbye, JG Diness, US Sørensen, RS Hansen, M Grunnet Journal of cardiovascular pharmacology 57 (6), 672-681, 2011 | 94 | 2011 |
Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses MM Haugaard, EZ Hesselkilde, S Pehrson, H Carstensen, M Flethøj, ... Heart rhythm 12 (4), 825-835, 2015 | 77 | 2015 |
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs JG Diness, L Skibsbye, R Simó-Vicens, JL Santos, P Lundegaard, ... Circulation: Arrhythmia and Electrophysiology 10 (10), e005125, 2017 | 68 | 2017 |
Cardiac ion channels and mechanisms for protection against atrial fibrillation M Grunnet, BH Bentzen, US Sørensen, JG Diness Reviews of Physiology, Biochemistry and Pharmacology: Volume 162, 1-58, 2012 | 48 | 2012 |
Role of calcium-activated potassium channels in atrial fibrillation pathophysiology and therapy JG Diness, BH Bentzen, US Sørensen, M Grunnet Journal of Cardiovascular Pharmacology 66 (5), 441-448, 2015 | 42 | 2015 |
Synergistic antiarrhythmic effect of combining inhibition of Ca2+-activated K+ (SK) channels and voltage-gated Na+ channels in an isolated heart model of atrial fibrillation JE Kirchhoff, JG Diness, M Sheykhzade, M Grunnet, T Jespersen Heart Rhythm 12 (2), 409-418, 2015 | 35 | 2015 |
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in … JG Diness, JE Kirchhoff, T Speerschneider, L Abildgaard, N Edvardsson, ... Frontiers in Pharmacology 11, 159, 2020 | 31 | 2020 |
Antiarrhythmic and electrophysiologic effects of flecainide on acutely induced atrial fibrillation in healthy horses MM Haugaard, S Pehrson, H Carstensen, M Flethøj, EZ Hesselkilde, ... Journal of veterinary internal medicine 29 (1), 339-347, 2015 | 29 | 2015 |
A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels R Simó‐Vicens, JE Kirchhoff, B Dolce, L Abildgaard, T Speerschneider, ... British journal of pharmacology 174 (23), 4396-4408, 2017 | 28 | 2017 |
Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes JD Nissen, JG Diness, TG Diness, RS Hansen, M Grunnet, T Jespersen Journal of cardiovascular pharmacology 54 (2), 169-177, 2009 | 28 | 2009 |
First Clinical Study with AP30663 ‐ a KCa2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation P Gal, ES Klaassen, KR Bergmann, M Saghari, J Burggraaf, MJB Kemme, ... Clinical and Translational Science 13 (6), 1336-1344, 2020 | 23 | 2020 |
Mechanisms of action of the KCa2-negative modulator AP30663, a novel compound in development for treatment of atrial fibrillation in man BH Bentzen, SH Bomholtz, R Simó-Vicens, L Folkersen, L Abildgaard, ... Frontiers in Pharmacology 11, 610, 2020 | 22 | 2020 |
Antiarrhythmic effect of IKr activation in a cellular model of LQT3 JG Diness, RS Hansen, JD Nissen, T Jespersen, M Grunnet Heart Rhythm 6 (1), 100-106, 2009 | 21 | 2009 |
pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts MA Skarsfeldt, TA Jepps, SH Bomholtz, L Abildgaard, US Sørensen, ... Pflügers Archiv-European Journal of Physiology 468, 643-654, 2016 | 20 | 2016 |
Pharmacological blockade of small conductance Ca2+-activated K+ channels by ICA reduces arrhythmic load in rats with acute myocardial infarction LA Hundahl, SM Sattler, L Skibsbye, JG Diness, J Tfelt-Hansen, ... Pflügers Archiv-European Journal of Physiology 469, 739-750, 2017 | 18 | 2017 |
Antiarrhythmic effect of either negative modulation or blockade of small conductance ca2+-activated k+ channels on ventricular fibrillation in guinea pig langendorff-perfused heart JG Diness, JE Kirchhoff, M Sheykhzade, T Jespersen, M Grunnet Journal of cardiovascular pharmacology 66 (3), 294-299, 2015 | 18 | 2015 |