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Julie Klint
Julie Klint
Lundbeck A/S
Email verificata su lundbeck.com
Titolo
Citata da
Citata da
Anno
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads
JK Klint, S Senff, DB Rupasinghe, SY Er, V Herzig, GM Nicholson, ...
Toxicon 60 (4), 478-491, 2012
2472012
Discovery of a selective NaV1. 7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
S Yang, Y Xiao, D Kang, J Liu, Y Li, EAB Undheim, JK Klint, M Rong, ...
Proceedings of the National Academy of Sciences 110 (43), 17534-17539, 2013
2082013
Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli
JK Klint, S Senff, NJ Saez, R Seshadri, HY Lau, NS Bende, EAB Undheim, ...
PloS one 8 (5), e63865, 2013
1732013
From foe to friend: using animal toxins to investigate ion channel function
J Kalia, M Milescu, J Salvatierra, J Wagner, JK Klint, GF King, BM Olivera, ...
Journal of molecular biology 427 (1), 158-175, 2015
1682015
Seven novel modulators of the analgesic target NaV1.7 uncovered using a high‐throughput venom‐based discovery approach
JK Klint, JJ Smith, I Vetter, DB Rupasinghe, SY Er, S Senff, V Herzig, ...
British journal of pharmacology 172 (10), 2445-2458, 2015
902015
Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and …
S Werner, S Mesch, RC Hillig, A Ter Laak, J Klint, I Neagoe, ...
Journal of Medicinal Chemistry 62 (24), 11194-11217, 2019
382019
Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1. 7
JK Klint, YKY Chin, M Mobli
Molecular Pharmacology 88 (6), 1002-1010, 2015
322015
Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels
JK Klint, G Berecki, T Durek, M Mobli, O Knapp, GF King, DJ Adams, ...
Biochemical Pharmacology 89 (2), 276-286, 2014
232014
Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization
J Gonzales, G Pirovano, CY Chow, PD de Souza Franca, LM Carter, ...
EJNMMI research 10, 1-8, 2020
152020
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3. 1 channel reveal a novel binding site for positive modulators
M Botte, S Huber, D Bucher, JK Klint, D Rodríguez, L Tagmose, M Chami, ...
PNAS nexus 1 (3), pgac083, 2022
52022
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3. 1 reveal a novel binding site for positive modulators
M Botte, S Huber, D Bucher, JK Klint, D Rodríguez, L Tagmose, M Chami, ...
bioRxiv, 2021.07. 13.452180, 2021
22021
31. Spider-venom Peptides that Target the Human NaV1. 7 channel: Potential Analgesics for the Treatment of Chronic Pain
J Klint, R Anangi, M Mobli, O Knapp, DJ Adams, GF King
Toxicon 2 (60), 110-111, 2012
22012
Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization
G Junior, P Giacomo, CY Chow, LM Carter, JK Klint, G Navjot, JS Lewis, ...
EJNMMI Research 10 (1), 2020
2020
So potent wie Morphin
S Yang, Y Xiao, D Kang, J Liu, Y Li, EA Undheim, JK Klint, M Rong, R Lai, ...
Journal Club Schmerzmedizin 3 (01), 46-46, 2014
2014
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional
JK Klint, S Senff, NJ Saez, R Seshadri, HY Lau
2013
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
Articoli 1–15