| The serpins are an expanding superfamily of structurally similar but functionally diverse proteins GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ... Journal of Biological Chemistry 276 (36), 33293-33296, 2001 | 1573 | 2001 |
| C. elegans in high-throughput drug discovery LP O'Reilly, CJ Luke, DH Perlmutter, GA Silverman, SC Pak Advanced drug delivery reviews 69, 247-253, 2014 | 265 | 2014 |
| Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous … GA Silverman, JC Whisstock, DJ Askew, SC Pak, CJ Luke, S Cataltepe, ... Cellular and Molecular Life Sciences CMLS 61, 301-325, 2004 | 211 | 2004 |
| Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z SJ Gosai, JH Kwak, CJ Luke, OS Long, DE King, KJ Kovatch, ... PloS one 5 (11), e15460, 2010 | 208 | 2010 |
| An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury CJ Luke, SC Pak, YS Askew, TL Naviglia, DJ Askew, SM Nobar, ... Cell 130 (6), 1108-1119, 2007 | 202 | 2007 |
| Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems GA Silverman, JC Whisstock, SP Bottomley, JA Huntington, D Kaiserman, ... Journal of Biological Chemistry 285 (32), 24299-24305, 2010 | 163 | 2010 |
| Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner CG Drummond, AM Bolock, C Ma, CJ Luke, M Good, CB Coyne Proceedings of the National Academy of Sciences 114 (7), 1672-1677, 2017 | 141 | 2017 |
| Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions JC Whisstock, GA Silverman, PI Bird, SP Bottomley, D Kaiserman, ... Journal of Biological Chemistry 285 (32), 24307-24312, 2010 | 124 | 2010 |
| Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans GA Silverman, CJ Luke, SR Bhatia, OS Long, AC Vetica, DH Perlmutter, ... Pediatric research 65 (1), 10-18, 2009 | 120 | 2009 |
| Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells Y Uemura, SC Pak, C Luke, S Çataltepe, C Tsu, C Schick, Y Kamachi, ... International journal of cancer 89 (4), 368-377, 2000 | 95 | 2000 |
| The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases M Al-Khunaizi, CJ Luke, YS Askew, SC Pak, DJ Askew, S Cataltepe, ... Biochemistry 41 (9), 3189-3199, 2002 | 84 | 2002 |
| Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis MM Myerburg, EE McKenna, CJ Luke, RA Frizzell, TR Kleyman, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 294 (5 …, 2008 | 71 | 2008 |
| SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases YS Askew, SC Pak, CJ Luke, DJ Askew, S Cataltepe, DR Mills, H Kato, ... Journal of Biological Chemistry 276 (52), 49320-49330, 2001 | 71 | 2001 |
| Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer S Markovina, S Wang, LE Henke, CJ Luke, SC Pak, T DeWees, JD Pfeifer, ... British journal of cancer 118 (1), 72-78, 2018 | 60 | 2018 |
| Simple Modifications of the Serpin Reactive Site Loop Convert SCCA2 into a Cysteine Proteinase Inhibitor: A Critical Role for the P3 ‘Proline in Facilitating RSL Cleavage C Luke, C Schick, C Tsu, JC Whisstock, JA Irving, D Brömme, L Juliano, ... Biochemistry 39 (24), 7081-7091, 2000 | 60 | 2000 |
| Recombinant Semliki Forest virus vector exhibits potential for avian virus vaccine development KV Phenix, K Wark, CJ Luke, MA Skinner, JA Smyth, KA Mawhinney, ... Vaccine 19 (23-24), 3116-3123, 2001 | 59 | 2001 |
| Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2 S Çataltepe, C Schick, CJ Luke, SCO Pak, D Goldfarb, P Chen, ... Clinica chimica acta 295 (1-2), 107-127, 2000 | 53 | 2000 |
| SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins SC Pak, V Kumar, C Tsu, CJ Luke, YS Askew, DJ Askew, DR Mills, ... Journal of Biological Chemistry 279 (15), 15448-15459, 2004 | 51 | 2004 |
| A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans MT Miedel, NJ Graf, KE Stephen, OS Long, SC Pak, DH Perlmutter, ... PloS one 7 (7), e40145, 2012 | 44 | 2012 |
| A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency LP O'Reilly, OS Long, MC Cobanoglu, JA Benson, CJ Luke, MT Miedel, ... Human molecular genetics 23 (19), 5123-5132, 2014 | 43 | 2014 |
Gary A SilvermanWashington University Scool of MedicineVerified email at wustl.edu
