| The serpins are an expanding superfamily of structurally similar but functionally diverse proteins GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ... Journal of Biological Chemistry 276 (36), 33293-33296, 2001 | 1400 | 2001 |
| Prediction of protein function from protein sequence and structure JC Whisstock, AM Lesk Quarterly reviews of biophysics 36 (3), 307, 2003 | 775 | 2003 |
| MUSTANG: a multiple structural alignment algorithm AS Konagurthu, JC Whisstock, PJ Stuckey, AM Lesk Proteins: Structure, Function, and Bioinformatics 64 (3), 559-574, 2006 | 693 | 2006 |
| Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function JA Irving, RN Pike, AM Lesk, JC Whisstock Genome research 10 (12), 1845-1864, 2000 | 683 | 2000 |
| An overview of the serpin superfamily RHP Law, Q Zhang, S McGowan, AM Buckle, GA Silverman, W Wong, ... Genome biology 7 (5), 1-11, 2006 | 596 | 2006 |
| Perforin and granzymes: function, dysfunction and human pathology I Voskoboinik, JC Whisstock, JA Trapani Nature Reviews Immunology 15 (6), 388-400, 2015 | 515 | 2015 |
| A structural basis for the selection of dominant αβ T cell receptors in antiviral immunity L Kjer-Nielsen, CS Clements, AW Purcell, AG Brooks, JC Whisstock, ... Immunity 18 (1), 53-64, 2003 | 375 | 2003 |
| AB 5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP AW Paton, T Beddoe, CM Thorpe, JC Whisstock, MCJ Wilce, J Rossjohn, ... Nature 443 (7111), 548-552, 2006 | 346 | 2006 |
| The structural basis for membrane binding and pore formation by lymphocyte perforin RHP Law, N Lukoyanova, I Voskoboinik, TT Caradoc-Davies, K Baran, ... Nature 468 (7322), 447-451, 2010 | 337 | 2010 |
| T cell receptor recognition of a'super-bulged'major histocompatibility complex class I–bound peptide FE Tynan, SR Burrows, AM Buckle, CS Clements, NA Borg, JJ Miles, ... Nature immunology 6 (11), 1114-1122, 2005 | 291 | 2005 |
| A common fold mediates vertebrate defense and bacterial attack CJ Rosado, AM Buckle, RHP Law, RE Butcher, WT Kan, CH Bird, K Ung, ... Science 317 (5844), 1548-1551, 2007 | 271 | 2007 |
| The MACPF/CDC family of pore‐forming toxins CJ Rosado, S Kondos, TE Bull, MJ Kuiper, RHP Law, AM Buckle, ... Cellular microbiology 10 (9), 1765-1774, 2008 | 266 | 2008 |
| Conservation within the myosin motor domain: implications for structure and function MJTV Cope, J Whisstock, I Rayment, J Kendrick-Jones Structure 4 (8), 969-987, 1996 | 262 | 1996 |
| Glycoprotein Ib–IX–V RK Andrews, EE Gardiner, Y Shen, JC Whisstock, MC Berndt The international journal of biochemistry & cell biology 35 (8), 1170-1174, 2003 | 258 | 2003 |
| IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction CA Nold-Petry, CY Lo, I Rudloff, KD Elgass, S Li, MP Gantier, ... Nature immunology 16 (4), 354, 2015 | 256 | 2015 |
| Perforin: structure, function, and role in human immunopathology I Voskoboinik, MA Dunstone, K Baran, JC Whisstock, JA Trapani Immunological reviews 235 (1), 35-54, 2010 | 223 | 2010 |
| The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site R Skinner, JP Abrahams, JC Whisstock, AM Lesk, RW Carrell, ... Journal of molecular biology 266 (3), 601-609, 1997 | 222 | 1997 |
| The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-κB p65 HJ Newton, JS Pearson, L Badea, M Kelly, M Lucas, G Holloway, ... PLoS Pathog 6 (5), e1000898, 2010 | 220 | 2010 |
| An atlas of serpin conformations J Whisstock, R Skinner, AM Lesk Trends in biochemical sciences 23 (2), 63-67, 1998 | 216 | 1998 |
| PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites J Song, H Tan, AJ Perry, T Akutsu, GI Webb, JC Whisstock, RN Pike PloS one 7 (11), e50300, 2012 | 207 | 2012 |
