| The serpins are an expanding superfamily of structurally similar but functionally diverse proteins evolution, mechanism of inhibition, novel functions, and a revised nomenclature GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ... Journal of Biological Chemistry 276 (36), 33293-33296, 2001 | 1361 | 2001 |
| Prediction of protein function from protein sequence and structure JC Whisstock, AM Lesk Quarterly reviews of biophysics 36 (3), 307, 2003 | 750 | 2003 |
| Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function JA Irving, RN Pike, AM Lesk, JC Whisstock Genome research 10 (12), 1845-1864, 2000 | 677 | 2000 |
| MUSTANG: a multiple structural alignment algorithm AS Konagurthu, JC Whisstock, PJ Stuckey, AM Lesk Proteins: Structure, Function, and Bioinformatics 64 (3), 559-574, 2006 | 675 | 2006 |
| An overview of the serpin superfamily RHP Law, Q Zhang, S McGowan, AM Buckle, GA Silverman, W Wong, ... Genome biology 7 (5), 1-11, 2006 | 567 | 2006 |
| Perforin and granzymes: function, dysfunction and human pathology I Voskoboinik, JC Whisstock, JA Trapani Nature Reviews Immunology 15 (6), 388-400, 2015 | 461 | 2015 |
| A structural basis for the selection of dominant αβ T cell receptors in antiviral immunity L Kjer-Nielsen, CS Clements, AW Purcell, AG Brooks, JC Whisstock, ... Immunity 18 (1), 53-64, 2003 | 368 | 2003 |
| AB 5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP AW Paton, T Beddoe, CM Thorpe, JC Whisstock, MCJ Wilce, J Rossjohn, ... Nature 443 (7111), 548-552, 2006 | 341 | 2006 |
| The structural basis for membrane binding and pore formation by lymphocyte perforin RHP Law, N Lukoyanova, I Voskoboinik, TT Caradoc-Davies, K Baran, ... Nature 468 (7322), 447-451, 2010 | 318 | 2010 |
| T cell receptor recognition of a'super-bulged'major histocompatibility complex class I–bound peptide FE Tynan, SR Burrows, AM Buckle, CS Clements, NA Borg, JJ Miles, ... Nature immunology 6 (11), 1114-1122, 2005 | 283 | 2005 |
| Conservation within the myosin motor domain: implications for structure and function MJTV Cope, J Whisstock, I Rayment, J Kendrick-Jones Structure 4 (8), 969-987, 1996 | 262 | 1996 |
| A common fold mediates vertebrate defense and bacterial attack CJ Rosado, AM Buckle, RHP Law, RE Butcher, WT Kan, CH Bird, K Ung, ... Science 317 (5844), 1548-1551, 2007 | 260 | 2007 |
| Glycoprotein Ib–IX–V RK Andrews, EE Gardiner, Y Shen, JC Whisstock, MC Berndt The international journal of biochemistry & cell biology 35 (8), 1170-1174, 2003 | 252 | 2003 |
| The MACPF/CDC family of pore‐forming toxins CJ Rosado, S Kondos, TE Bull, MJ Kuiper, RHP Law, AM Buckle, ... Cellular microbiology 10 (9), 1765-1774, 2008 | 248 | 2008 |
| IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction CA Nold-Petry, CY Lo, I Rudloff, KD Elgass, S Li, MP Gantier, ... Nature immunology 16 (4), 354, 2015 | 242 | 2015 |
| The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-κB p65 HJ Newton, JS Pearson, L Badea, M Kelly, M Lucas, G Holloway, ... PLoS Pathog 6 (5), e1000898, 2010 | 220 | 2010 |
| The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site R Skinner, JP Abrahams, JC Whisstock, AM Lesk, RW Carrell, ... Journal of molecular biology 266 (3), 601-609, 1997 | 217 | 1997 |
| Perforin: structure, function, and role in human immunopathology I Voskoboinik, MA Dunstone, K Baran, JC Whisstock, JA Trapani Immunological reviews 235 (1), 35-54, 2010 | 216 | 2010 |
| An atlas of serpin conformations J Whisstock, R Skinner, AM Lesk Trends in biochemical sciences 23 (2), 63-67, 1998 | 215 | 1998 |
| PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites J Song, H Tan, AJ Perry, T Akutsu, GI Webb, JC Whisstock, RN Pike PloS one 7 (11), e50300, 2012 | 193 | 2012 |
