Peter Orth
Peter Orth
BEST, Merck & Co.
Email verificata su merck.com
TitoloCitata daAnno
Crystal structure of photosystem II from Synechococcus elongatus at 3.8 ┼ resolution
A Zouni, HT Witt, J Kern, P Fromme, N Krauss, W Saenger, P Orth
Nature 409 (6821), 739-743, 2001
22822001
Structural basis of gene regulation by the tetracycline inducible Tet repressor–operator system
P Orth, D Schnappinger, W Hillen, W Saenger, W Hinrichs
Nature structural biology 7 (3), 215-219, 2000
4902000
Excited-state dynamics in photosystem II: Insights from the x-ray crystal structure
S Vasil'ev, P Orth, A Zouni, TG Owens, D Bruce
Proceedings of the National Academy of Sciences 98 (15), 8602-8607, 2001
1492001
The tetracycline repressor—a paradigm for a biological switch
W Saenger, P Orth, C Kisker, W Hillen, W Hinrichs
Angewandte Chemie International Edition 39 (12), 2042-2052, 2000
1492000
Conformational changes of the Tet repressor induced by tetracycline trapping
P Orth, F Cordes, D Schnappinger, W Hillen, W Saenger, W Hinrichs
Journal of molecular biology 279 (2), 439-447, 1998
1441998
Crystal structure of the catalytic domain of human ADAM33
P Orth, P Reichert, W Wang, WW Prosise, T Yarosh-Tomaine, ...
Journal of molecular biology 335 (1), 129-137, 2004
892004
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography
P Orth, L Xiao, LD Hernandez, P Reichert, PR Sheth, M Beaumont, ...
Journal of biological chemistry 289 (26), 18008-18021, 2014
882014
Tetracycline-Chelated Mg2+ Ion Initiates Helix Unwinding in Tet Repressor Induction,
P Orth, W Saenger, W Hinrichs
Biochemistry 38 (1), 191-198, 1999
861999
Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ reduction
AW Stamford, JD Scott, SW Li, S Babu, D Tadesse, R Hunter, Y Wu, ...
ACS medicinal chemistry letters 3 (11), 897-902, 2012
852012
Photosystem II single crystals studied by EPR spectroscopy at 94 GHz: The tyrosine radical Y
W Hofbauer, A Zouni, R Bittl, J Kern, P Orth, F Lendzian, P Fromme, ...
Proceedings of the National Academy of Sciences 98 (12), 6623-6628, 2001
852001
Discovery of the 3-imino-1, 2, 4-thiadiazinane 1, 1-dioxide derivative verubecestat (MK-8931)–A β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatmentá…
JD Scott, SW Li, APJ Brunskill, X Chen, K Cox, JN Cumming, M Forman, ...
Journal of medicinal chemistry 59 (23), 10435-10450, 2016
802016
Crystal structure of ω transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 ┼ resolution
K Murayama, P Orth, AB de la Hoz, JC Alonso, W Saenger
Journal of molecular biology 314 (4), 789-796, 2001
772001
Engineered anti-IL-23 antibodies
LG Presta, BM Beyer, RN Ingram, P Orth, YH Liu
US Patent 7,807,160, 2010
682010
Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity
H Lan, CC Cheng, TJ Kowalski, L Pang, L Shan, CC Chuang, J Jackson, ...
Journal of lipid research 52 (4), 646-656, 2011
642011
Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N, N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline
P Orth, D Schnappinger, PE Sum, GA Ellestad, W Hillen, W Saenger, ...
Journal of molecular biology 285 (2), 455-461, 1999
601999
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation
M Mandal, Z Zhu, JN Cumming, X Liu, C Strickland, RD Mazzola, ...
Journal of medicinal chemistry 55 (21), 9331-9345, 2012
552012
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
J Cumming, S Babu, Y Huang, C Carrol, X Chen, L Favreau, W Greenlee, ...
Bioorganic & medicinal chemistry letters 20 (9), 2837-2842, 2010
552010
Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex
GJ Palm, T Lederer, P Orth, W Saenger, M Takahashi, W Hillen, ...
JBIC Journal of Biological Inorganic Chemistry 13 (7), 1097, 2008
542008
Discovery and optimization of antibacterial AccC inhibitors
CC Cheng, GW Shipps Jr, Z Yang, B Sun, N Kawahata, KA Soucy, ...
Bioorganic & medicinal chemistry letters 19 (23), 6507-6514, 2009
532009
Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
BM Beyer, R Ingram, L Ramanathan, P Reichert, HV Le, V Madison, ...
Journal of molecular biology 382 (4), 942-955, 2008
492008
Il sistema al momento non pu˛ eseguire l'operazione. Riprova pi¨ tardi.
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