|Circulating microRNAs as novel biomarkers for platelet activation|
P Willeit, A Zampetaki, K Dudek, D Kaudewitz, A King, NS Kirkby, ...
Circulation research 112 (4), 595-600, 2013
|The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?|
NS Kirkby, PWF Hadoke, AJ Bagnall, DJ Webb
British journal of pharmacology 153 (6), 1105-1119, 2008
|Pyridine‐and Imidazoledicarboxylates of Zinc: Hydrothermal Synthesis, Structure, and Properties|
P Mahata, S Natarajan
European journal of inorganic chemistry 2005 (11), 2156-2163, 2005
|Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system|
NS Kirkby, MH Lundberg, LS Harrington, PDM Leadbeater, GL Milne, ...
Proceedings of the National Academy of Sciences 109 (43), 17597-17602, 2012
|Systematic study of constitutive cyclooxygenase-2 expression: role of NF-κB and NFAT transcriptional pathways|
NS Kirkby, MV Chan, AK Zaiss, E Garcia-Vaz, J Jiao, LM Berglund, ...
Proceedings of the National Academy of Sciences 113 (2), 434-439, 2016
|In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation|
PCJ Armstrong, PD Leadbeater, MV Chan, NS Kirkby, JA Jakubowski, ...
Journal of Thrombosis and Haemostasis 9 (3), 552-561, 2011
|Evidence for the involvement of type I interferon in pulmonary arterial hypertension|
PM George, E Oliver, P Dorfmuller, OD Dubois, DM Reed, NS Kirkby, ...
Circulation research 114 (4), 677-688, 2014
|Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs|
B Ahmetaj-Shala, NS Kirkby, R Knowles, M Al’Yamani, S Mazi, Z Wang, ...
Circulation 131 (7), 633-642, 2015
|Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α|
MA Brooke, HJ Longhurst, V Plagnol, NS Kirkby, JA Mitchell, ...
Gut 63 (1), 96-104, 2014
|Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel|
NS Kirkby, PDM Leadbeater, MV Chan, S Nylander, JA Mitchell, ...
Journal of Thrombosis and Haemostasis 9 (10), 2103, 2011
|LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression|
NS Kirkby, AK Zaiss, P Urquhart, J Jiao, PJ Austin, M Al-Yamani, ...
PloS one 8 (7), e69524, 2013
|Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide|
NS Kirkby, MH Lundberg, MV Chan, I Vojnovic, AB Solomon, M Emerson, ...
Proceedings of the National Academy of Sciences 110 (39), 15782-15787, 2013
|Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay|
M Lordkipanidzé, GC Lowe, NS Kirkby, MV Chan, MH Lundberg, ...
Blood, The Journal of the American Society of Hematology 123 (8), e11-e22, 2014
|Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing|
MV Chan, PCJ Armstrong, F Papalia, NS Kirkby, TD Warner
Platelets 22 (7), 485-494, 2011
|Role of prostacyclin in pulmonary hypertension|
JA Mitchell, B Ahmetaj-Shala, NS Kirkby, WR Wright, LS Mackenzie, ...
Global Cardiology Science and Practice 2014 (4), 53, 2015
|Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia|
RE di Villa Bianca, E Mitidieri, MND Di Minno, NS Kirkby, TD Warner, ...
Proceedings of the National Academy of Sciences 110 (39), 15812-15817, 2013
|COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks|
NS Kirkby, MH Lundberg, WR Wright, TD Warner, MJ Paul-Clark, ...
PloS one 9 (6), e98165, 2014
|Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system|
JA Mitchell, NS Kirkby
British journal of pharmacology 176 (8), 1038-1050, 2019
|Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies|
NS Kirkby, AK Zaiss, WR Wright, J Jiao, MV Chan, TD Warner, ...
Biochemical and biophysical research communications 438 (2), 249-256, 2013
|Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse|
PC Armstrong, NS Kirkby, ZN Zain, M Emerson, JA Mitchell, TD Warner
PLoS One 6 (5), e20062, 2011