| Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 943 | 2013 |
| The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ... British journal of pharmacology 178, S27-S156, 2021 | 445 | 2021 |
| Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ... Nature 503 (7475), 295-299, 2013 | 431 | 2013 |
| Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner … C Koole, D Wootten, J Simms, C Valant, R Sridhar, OL Woodman, ... Molecular pharmacology 78 (3), 456-465, 2010 | 225 | 2010 |
| A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND∗ C Valant, KJ Gregory, NE Hall, PJ Scammells, MJ Lew, PM Sexton, ... Journal of biological chemistry 283 (43), 29312-29321, 2008 | 197 | 2008 |
| The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein–coupled receptors C Valant, J Robert Lane, PM Sexton, A Christopoulos Annual review of pharmacology and toxicology 52, 153-178, 2012 | 186 | 2012 |
| Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor AE Davey, K Leach, C Valant, AD Conigrave, PM Sexton, A Christopoulos Endocrinology 153 (3), 1232-1241, 2012 | 180 | 2012 |
| Endogenous allosteric modulators of G protein–coupled receptors ET van der Westhuizen, C Valant, PM Sexton, A Christopoulos Journal of Pharmacology and Experimental Therapeutics 353 (2), 246-260, 2015 | 149 | 2015 |
| Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects C Valant, CC Felder, PM Sexton, A Christopoulos Molecular pharmacology 81 (1), 41-52, 2012 | 142 | 2012 |
| Allosteric Modulators of the Adenosine A1 Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes L Aurelio, C Valant, BL Flynn, PM Sexton, A Christopoulos, PJ Scammells Journal of medicinal chemistry 52 (14), 4543-4547, 2009 | 133 | 2009 |
| Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist C Valant, LT May, L Aurelio, CH Chuo, PJ White, JA Baltos, PM Sexton, ... Proceedings of the National Academy of Sciences 111 (12), 4614-4619, 2014 | 116 | 2014 |
| Orthosteric/allosteric bitopic ligands C Valant, PM Sexton, A Christopoulos Molecular interventions 9 (3), 125, 2009 | 113 | 2009 |
| A novel, conformation‐specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties EL Maillet, N Pellegrini, C Valant, B Bucher, M Hibert, JJ Bourguignon, ... The FASEB Journal 21 (9), 2124-2134, 2007 | 100 | 2007 |
| Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation C Koole, D Wootten, J Simms, C Valant, LJ Miller, A Christopoulos, ... Molecular pharmacology 80 (3), 486-497, 2011 | 97 | 2011 |
| Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia CJ Draper-Joyce, R Bhola, J Wang, A Bhattarai, ATN Nguyen, ... Nature 597 (7877), 571-576, 2021 | 92 | 2021 |
| Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor Y Miao, DA Goldfeld, EV Moo, PM Sexton, A Christopoulos, ... Proceedings of the National Academy of Sciences 113 (38), E5675-E5684, 2016 | 91 | 2016 |
| Allosteric modulation of endogenous metabolites as an avenue for drug discovery D Wootten, EE Savage, C Valant, LT May, KW Sloop, J Ficorilli, ... Molecular pharmacology 82 (2), 281-290, 2012 | 84 | 2012 |
| Synthesis and Pharmacological Profiling of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) as Allosteric Modulators of the M1 Muscarinic Receptor SN Mistry, C Valant, PM Sexton, B Capuano, A Christopoulos, ... Journal of medicinal chemistry 56 (12), 5151-5172, 2013 | 75 | 2013 |
| Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor P Keov, L Lopez, SM Devine, C Valant, JR Lane, PJ Scammells, ... Journal of Biological Chemistry 289 (34), 23817-23837, 2014 | 73 | 2014 |
| Crystal structure of the M5 muscarinic acetylcholine receptor Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ... Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019 | 70 | 2019 |
Arthur ChristopoulosMonash UniversityVerified email at monash.edu
