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ELENA MARIA TOSCA
ELENA MARIA TOSCA
Verified email at universitadipavia.it
Title
Cited by
Cited by
Year
Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy assessment
EM Tosca, D Ronchi, D Facciolo, P Magni
Biomedicines 11 (4), 1058, 2023
322023
Staggered herringbone microfluid device for the manufacturing of chitosan/TPP nanoparticles: Systematic optimization and preliminary biological evaluation
E Chiesa, A Greco, F Riva, EM Tosca, R Dorati, S Pisani, T Modena, ...
International journal of molecular sciences 20 (24), 6212, 2019
322019
Application of artificial neural networks to predict the intrinsic solubility of drug-like molecules
EM Tosca, R Bartolucci, P Magni
Pharmaceutics 13 (7), 1101, 2021
222021
Modeling tumor growth inhibition and toxicity outcome after administration of anticancer agents in xenograft mice: a dynamic energy budget (DEB) approach
N Terranova, EM Tosca, E Borella, E Pesenti, M Rocchetti, P Magni
Journal of theoretical biology 450, 1-14, 2018
142018
A tumor-in-host DEB-based approach for modeling cachexia and bevacizumab resistance
EM Tosca, M Rocchetti, E Pesenti, P Magni
Cancer Research 80 (4), 820-831, 2020
132020
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity
EM Tosca, R Bartolucci, P Magni, I Poggesi
Expert Opinion on Drug Discovery 16 (11), 1365-1390, 2021
112021
In vitro–in vivo correlation (IVIVC) population modeling for the in silico bioequivalence of a long-acting release formulation of progesterone
EM Tosca, M Rocchetti, E Pérez, C Nieto, P Bettica, J Moscoso del Prado, ...
Pharmaceutics 13 (2), 255, 2021
112021
A population dynamic energy budget-based tumor growth inhibition model for etoposide effects on Wistar rats
EM Tosca, MC Pigatto, T Dalla Costa, P Magni
Pharmaceutical research 36, 1-13, 2019
112019
Model‐based prediction of effective target exposure for MEN1611 in combination with trastuzumab in HER2‐positive advanced or metastatic breast cancer patients
EM Tosca, E Borella, C Piana, S Bouchene, G Merlino, A Fiascarelli, ...
CPT: Pharmacometrics & Systems Pharmacology 12 (11), 1626-1639, 2023
82023
mvLognCorrEst: an R package for sampling from multivariate lognormal distributions and estimating correlations from uncomplete correlation matrix
A De Carlo, EM Tosca, N Melillo, P Magni
Computer Methods and Programs in Biomedicine 235, 107517, 2023
82023
Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: a tumor‐in‐host DEB‐based approach
EM Tosca, G Gauderat, S Fouliard, M Burbridge, M Chenel, P Magni
CPT: Pharmacometrics & Systems Pharmacology 10 (11), 1396-1411, 2021
82021
A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies
EM Tosca, M Rocchetti, P Magni
Oncotarget 12 (14), 1434, 2021
82021
A translational model-based approach to inform the choice of the dose in phase 1 oncology trials: the case study of erdafitinib
EM Tosca, N Terranova, K Stuyckens, AG Dosne, T Perera, J Vialard, ...
Cancer Chemotherapy and Pharmacology 89 (1), 117-128, 2022
72022
Artificial intelligence and machine learning: just a hype or a new opportunity for pharmacometrics
R Bartolucci, S Grandoni, N Melillo, G Nicora, E Sauta, EM Tosca, ...
Page Meet 28, 2019
62019
Go beyond the limits of genetic algorithm in daily covariate selection practice
D Ronchi, EM Tosca, R Bartolucci, P Magni
Journal of Pharmacokinetics and Pharmacodynamics 51 (2), 109-121, 2024
42024
Model‐informed reinforcement learning for enabling precision dosing via adaptive dosing
EM Tosca, A De Carlo, D Ronchi, P Magni
Clinical Pharmacology & Therapeutics 116 (3), 619-636, 2024
32024
Reinforcement Learning and PK‐PD Models Integration to Personalize the Adaptive Dosing Protocol of Erdafitinib in Patients with Metastatic Urothelial Carcinoma
A De Carlo, EM Tosca, M Fantozzi, P Magni
Clinical Pharmacology & Therapeutics 115 (4), 825-838, 2024
32024
In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients
EM Tosca, A De Carlo, R Bartolucci, F Fiorentini, S Di Tollo, M Caserini, ...
CPT: Pharmacometrics & Systems Pharmacology 13 (3), 359-373, 2024
32024
A two-stages global sensitivity analysis by using the δ sensitivity index in presence of correlated inputs: application on a tumor growth inhibition model based on the dynamic …
A De Carlo, EM Tosca, N Melillo, P Magni
Journal of Pharmacokinetics and Pharmacodynamics 50 (5), 395-409, 2023
32023
Modeling resistance development to Bevacizumab in xenograft experiments by coupling hypoxia-mediated mechanism and a Dynamic Energy Budget (DEB) based tumor-in-host model
E Tosca, M Rocchetti, E Pesenti, P Magni
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 45, S25-S26, 2018
32018
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