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Takatsugu Hirokawa
Takatsugu Hirokawa
Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Bestätigte E-Mail-Adresse bei aist.go.jp
Titel
Zitiert von
Zitiert von
Jahr
SOSUI: classification and secondary structure prediction system for membrane proteins.
T Hirokawa, S Boon-Chieng, S Mitaku
Bioinformatics (Oxford, England) 14 (4), 378-379, 1998
21621998
Ubiquitin is phosphorylated by PINK1 to activate parkin
F Koyano, K Okatsu, H Kosako, Y Tamura, E Go, M Kimura, Y Kimura, ...
Nature 510 (7503), 162-166, 2014
11992014
Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site
S Katada, T Hirokawa, Y Oka, M Suwa, K Touhara
Journal of Neuroscience 25 (7), 1806-1815, 2005
3322005
Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane–water interfaces
S Mitaku, T Hirokawa, T Tsuji
Bioinformatics 18 (4), 608-616, 2002
2422002
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
K Kawajiri, Y Kobayashi, F Ohtake, T Ikuta, Y Matsushima, J Mimura, ...
Proceedings of the national academy of sciences 106 (32), 13481-13486, 2009
2412009
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
H Koshimizu, K Kiyosue, T Hara, S Hazama, S Suzuki, K Uegaki, ...
Molecular brain 2 (1), 1-19, 2009
1932009
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants
K Nishikawa, H Li, R Kawamura, H Osaka, YL Wang, Y Hara, T Hirokawa, ...
Biochemical and biophysical research communications 304 (1), 176-183, 2003
1902003
Analysis of multiple compound–protein interactions reveals novel bioactive molecules
H Yabuuchi, S Niijima, H Takematsu, T Ida, T Hirokawa, T Hara, T Ogawa, ...
Molecular systems biology 7 (1), 472, 2011
1562011
Physicochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length
S Mitaku, T Hirokawa
Protein engineering 12 (11), 953-957, 1999
1011999
Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system
S Mitaku, M Ono, T Hirokawa, S Boon-Chieng, M Sonoyama
Biophysical Chemistry 82 (2-3), 165-171, 1999
751999
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface
Y Toyoda, K Morimoto, R Suno, S Horita, K Yamashita, K Hirata, ...
Nature chemical biology 15 (1), 18-26, 2019
732019
Engineering PQQ glucose dehydrogenase with improved substrate specificity: site-directed mutagenesis studies on the active center of PQQ glucose dehydrogenase
S Igarashi, T Hirokawa, K Sode
Biomolecular engineering 21 (2), 81-89, 2004
722004
GRIFFIN: a system for predicting GPCR–G-protein coupling selectivity using a support vector machine and a hidden Markov model
Y Yabuki, T Muramatsu, T Hirokawa, H Mukai, M Suwa
Nucleic acids research 33 (suppl_2), W148-W153, 2005
692005
Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Y Shinohara, YM Koyama, M Ukai-Tadenuma, T Hirokawa, M Kikuchi, ...
Molecular cell 67 (5), 783-798. e20, 2017
672017
Multidrug treatment with nelfinavir and cepharanthine against COVID-19
H Ohashi, K Watashi, W Saso, K Shionoya, S Iwanami, T Hirokawa, ...
BioRxiv, 2020
592020
Crystal structures of human orexin 2 receptor bound to the subtype-selective antagonist EMPA
R Suno, KT Kimura, T Nakane, K Yamashita, J Wang, T Fujiwara, ...
Structure 26 (1), 7-19. e5, 2018
582018
Molecular mechanisms for sweet-suppressing effect of gymnemic acids
K Sanematsu, Y Kusakabe, N Shigemura, T Hirokawa, S Nakamura, ...
Journal of Biological Chemistry 289 (37), 25711-25720, 2014
572014
Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation*♦
K Yamano, BB Queliconi, F Koyano, Y Saeki, T Hirokawa, K Tanaka, ...
Journal of Biological Chemistry 290 (42), 25199-25211, 2015
552015
Substrate specificity of microbial transglutaminase as revealed by three-dimensional docking simulation and mutagenesis
U Tagami, N Shimba, M Nakamura, K Yokoyama, E Suzuki, T Hirokawa
Protein Engineering, Design & Selection 22 (12), 747-752, 2009
552009
Protein structure prediction using a variety of profile libraries and 3D verification
K Tomii, T Hirokawa, C Motono
Proteins: Structure, Function, and Bioinformatics 61 (S7), 114-121, 2005
532005
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