Andrew D. Mesecar
Andrew D. Mesecar
Walther Professor of Structural Biology, Purdue University, Department of Biochemistry
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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
AL Eggler, G Liu, JM Pezzuto, RB Van Breemen, AD Mesecar
Proceedings of the National Academy of Sciences 102 (29), 10070-10075, 2005
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
N Barretto, D Jukneliene, K Ratia, Z Chen, AD Mesecar, SC Baker
Journal of virology 79 (24), 15189-15198, 2005
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds
YM BŠez-Santos, SES John, AD Mesecar
Antiviral research 115, 21-38, 2015
The allosteric regulation of pyruvate kinase by fructose-1, 6-bisphosphate
MS Jurica, A Mesecar, PJ Heath, W Shi, T Nowak, BL Stoddard
Structure 6 (2), 195-210, 1998
Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis,
JD Dombrauckas, BD Santarsiero, AD Mesecar
Biochemistry 44 (27), 9417-9429, 2005
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme
K Ratia, KS Saikatendu, BD Santarsiero, N Barretto, SC Baker, ...
Proceedings of the National Academy of Sciences 103 (15), 5717-5722, 2006
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms: direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
X Zhang, L Gan, H Pan, S Guo, X He, ST Olson, A Mesecar, S Adam, ...
Journal of Biological Chemistry 277 (47), 45276-45284, 2002
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
K Ratia, S Pegan, J Takayama, K Sleeman, M Coughlin, S Baliji, ...
Proceedings of the National Academy of Sciences 105 (42), 16119-16124, 2008
Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling
M Frieman, K Ratia, RE Johnston, AD Mesecar, RS Baric
Journal of virology 83 (13), 6689-6705, 2009
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor
JE Burdette, J Liu, S Chen, DS Fabricant, CE Piersen, EL Barker, ...
Journal of Agricultural and Food Chemistry 51 (19), 5661-5670, 2003
Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2
AL Eggler, KA Gay, AD Mesecar
Molecular nutrition & food research 52 (S1), S84-S94, 2008
Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase
BM Dietz, YH Kang, G Liu, AL Eggler, P Yao, LR Chadwick, GF Pauli, ...
Chemical research in toxicology 18 (8), 1296-1305, 2005
Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences
AD Mesecar, BL Stoddard, DE Koshland
Science 277 (5323), 202-206, 1997
Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases
MA Clementz, Z Chen, BS Banach, Y Wang, L Sun, K Ratia, ...
Journal of virology 84 (9), 4619-4629, 2010
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris
BY Hwang, BN Su, H Chai, Q Mi, LBS Kardono, JJ Afriastini, S Riswan, ...
The Journal of organic chemistry 69 (10), 3350-3358, 2004
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga, L Pache, ...
Nature 586 (7827), 113-119, 2020
Modification of keap1 cysteine residues by sulforaphane
C Hu, AL Eggler, AD Mesecar, RB Van Breemen
Chemical research in toxicology 24 (4), 515-521, 2011
New Chemical Constituents of Euphorbia quinquecostata and Absolute Configuration Assignment by a Convenient Mosher Ester Procedure Carried Out in NMR†…
BN Su, EJ Park, ZH Mbwambo, BD Santarsiero, AD Mesecar, HHS Fong, ...
Journal of natural products 65 (9), 1278-1282, 2002
Sites of alkylation of human Keap1 by natural chemoprevention agents
Y Luo, AL Eggler, D Liu, G Liu, AD Mesecar, RB van Breemen
Journal of the American Society for Mass Spectrometry 18 (12), 2226-2232, 2007
Pleiotropic mechanisms facilitated by resveratrol and its metabolites
B Calamini, K Ratia, MG Malkowski, M Cuendet, JM Pezzuto, ...
Biochemical Journal 429 (2), 273-282, 2010
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