| Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 181 | 2012 |
| Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels OB Clarke, AT Caputo, AP Hill, JI Vandenberg, BJ Smith, JM Gulbis Cell 141 (6), 1018-1029, 2010 | 167 | 2010 |
| Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases—not glycolipid processing enzymes AC Sayce, DS Alonzi, SS Killingbeck, BE Tyrrell, ML Hill, AT Caputo, ... PLoS neglected tropical diseases 10 (3), e0004524, 2016 | 82 | 2016 |
| Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals AT Caputo, DS Alonzi, L Marti, IB Reca, JL Kiappes, WB Struwe, A Cross, ... Proceedings of the National Academy of Sciences 113 (32), E4630-E4638, 2016 | 78 | 2016 |
| Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4 KL Warfield, EM Plummer, AC Sayce, DS Alonzi, W Tang, BE Tyrrell, ... Antiviral research 129, 93-98, 2016 | 68 | 2016 |
| Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint P Roversi, L Marti, AT Caputo, DS Alonzi, JC Hill, KC Dent, A Kumar, ... Proceedings of the National Academy of Sciences 114 (32), 8544-8549, 2017 | 55 | 2017 |
| ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting antiflaviviral activity JL Kiappes, ML Hill, DS Alonzi, JL Miller, R Iwaki, AC Sayce, AT Caputo, ... ACS Chemical Biology 13 (1), 60-65, 2018 | 45 | 2018 |
| Low pH and anionic lipid-dependent fusion of Uukuniemi phlebovirus to liposomes D Bitto, S Halldorsson, A Caputo, JT Huiskonen Journal of Biological Chemistry 291 (12), 6412-6422, 2016 | 45 | 2016 |
| Targeting endoplasmic reticulum α-glucosidase I with a single-dose iminosugar treatment protects against lethal influenza and dengue virus infections KL Warfield, DS Alonzi, JC Hill, AT Caputo, P Roversi, JL Kiappes, ... Journal of Medicinal Chemistry 63 (8), 4205-4214, 2020 | 42 | 2020 |
| Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability … Y Joho, V Vongsouthi, MA Spence, J Ton, C Gomez, LL Tan, ... Biochemistry 62 (2), 437-450, 2022 | 29 | 2022 |
| Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines RL Ambrose, AM Brice, AT Caputo, MR Alexander, L Tribolet, YC Liu, ... Heliyon 6 (6), 2020 | 14 | 2020 |
| Target highlights from the first post‐PSI CASP experiment (CASP12, May–August 2016) A Kryshtafovych, R Albrecht, A Basle, P Bule, AT Caputo, AL Carvalho, ... Proteins: Structure, Function, and Bioinformatics 86, 27-50, 2018 | 11 | 2018 |
| Allylic Azide Rearrangement in Tandem with Intramolecular Huisgen Cycloaddition for Iminosugar and Glycomimetic Synthesis: Functionalized Piperidine, Pyrrolidine, and … R Chadda, P McArdle, PV Murphy Synthesis 49 (10), 2138-2152, 2017 | 9 | 2017 |
| Bicyclic 1-azafagomine derivatives: synthesis and glycosidase inhibitory testing TCS Evangelista, Ó Lopéz, MO Sydnes, JG Fernandez-Bolanos, ... Synthesis 51 (21), 4066-4077, 2019 | 7 | 2019 |
| Dengue and Zika: Control and Antiviral Treatment Strategies AT Caputo, DS Alonzi, JL Kiappes, WB Struwe, A Cross, S Basu, B Darlot, ... Advances in experimental medicine and biology 1062, 265-276, 2018 | 7 | 2018 |
| Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II AT Caputo, DS Alonzi, JL Kiappes, WB Struwe, A Cross, S Basu, B Darlot, ... Dengue and Zika: Control and Antiviral Treatment Strategies, 265-276, 2018 | 7 | 2018 |
| Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor S Vasiljevic, EV Beale, C Bonomelli, IS Easthope, LK Pritchard, ... Molecular immunology 68 (2), 234-243, 2015 | 6 | 2015 |
| Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant … AT Caputo, OM Eder, H Bereznakova, H Pothuis, A Ardevol, J Newman, ... Scientific Reports 11 (1), 5247, 2021 | 5 | 2021 |
| Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed FH Ahmed, AT Caputo, NG French, TS Peat, J Whitfield, AC Warden, ... Acta Crystallographica Section D: Structural Biology 78 (5), 599-612, 2022 | 3 | 2022 |
| Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint AT Caputo, R Ibba, JD Le Cornu, B Darlot, M Hensen, CB Lipp, ... Frontiers in Molecular Biosciences 9, 960248, 2022 | 2 | 2022 |
