| MLL targets SET domain methyltransferase activity to Hox gene promoters TA Milne, SD Briggs, HW Brock, ME Martin, D Gibbs, CD Allis, JL Hess Molecular cell 10 (5), 1107-1117, 2002 | 1268 | 2002 |
| Altered Hox expression and segmental identity in Mll-mutant mice BD Yu, JL Hess, SE Horning, GAJ Brown, SJ Korsmeyer Nature 378 (6556), 505-508, 1995 | 1051 | 1995 |
| Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF Y Dou, TA Milne, AJ Tackett, ER Smith, A Fukuda, J Wysocka, CD Allis, ... Cell 121 (6), 873-885, 2005 | 790 | 2005 |
| Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus CM Hughes, O Rozenblatt-Rosen, TA Milne, TD Copeland, SS Levine, ... Molecular cell 13 (4), 587-597, 2004 | 727 | 2004 |
| Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors TA Milne, CM Hughes, R Lloyd, Z Yang, O Rozenblatt-Rosen, Y Dou, ... Proceedings of the National Academy of Sciences 102 (3), 749-754, 2005 | 534 | 2005 |
| A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification D Mueller, C Bach, D Zeisig, MP Garcia-Cuellar, S Monroe, A Sreekumar, ... Blood, The Journal of the American Society of Hematology 110 (13), 4445-4454, 2007 | 445 | 2007 |
| MLL: a histone methyltransferase disrupted in leukemia JL Hess Trends in molecular medicine 10 (10), 500-507, 2004 | 441 | 2004 |
| Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia J Grembecka, S He, A Shi, T Purohit, AG Muntean, RJ Sorenson, ... Nature chemical biology 8 (3), 277-284, 2012 | 422 | 2012 |
| MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis BD Yu, RD Hanson, JL Hess, SE Horning, SJ Korsmeyer Proceedings of the National Academy of Sciences 95 (18), 10632-10636, 1998 | 410 | 1998 |
| Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization BB Zeisig, T Milne, MP García-Cuéllar, S Schreiner, ME Martin, U Fuchs, ... Molecular and cellular biology 24 (2), 617-628, 2004 | 398 | 2004 |
| The pathogenesis of mixed-lineage leukemia AG Muntean, JL Hess Annual Review of Pathology: Mechanisms of Disease 7, 283-301, 2012 | 368 | 2012 |
| Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo D Borkin, S He, H Miao, K Kempinska, J Pollock, J Chase, T Purohit, ... Cancer cell 27 (4), 589-602, 2015 | 353 | 2015 |
| Mammalian Trithorax and Polycomb-group homologues are antagonistic regulators of homeotic development RD Hanson, JL Hess, BD Yu, P Ernst, M Van Lohuizen, A Berns, ... Proceedings of the National Academy of Sciences 96 (25), 14372-14377, 1999 | 334 | 1999 |
| Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos JL Hess, BD Yu, B Li, R Hanson, SJ Korsmeyer Blood, The Journal of the American Society of Hematology 90 (5), 1799-1806, 1997 | 334 | 1997 |
| Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia A Akalin, FE Garrett-Bakelman, M Kormaksson, J Busuttil, L Zhang, ... PLoS genetics 8 (6), e1002781, 2012 | 330 | 2012 |
| Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia F Cao, EC Townsend, H Karatas, J Xu, L Li, S Lee, L Liu, Y Chen, ... Molecular cell 53 (2), 247-261, 2014 | 319 | 2014 |
| MLL associates specifically with a subset of transcriptionally active target genes TA Milne, Y Dou, ME Martin, HW Brock, RG Roeder, JL Hess Proceedings of the National Academy of Sciences 102 (41), 14765-14770, 2005 | 277 | 2005 |
| The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis AG Muntean, J Tan, K Sitwala, Y Huang, J Bronstein, JA Connelly, ... Cancer cell 17 (6), 609-621, 2010 | 268 | 2010 |
| Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications TA Milne, ME Martin, HW Brock, RK Slany, JL Hess Cancer research 65 (24), 11367-11374, 2005 | 231 | 2005 |
| Identification and characterization of Hoxa9 binding sites in hematopoietic cells Y Huang, K Sitwala, J Bronstein, D Sanders, M Dandekar, C Collins, ... Blood, The Journal of the American Society of Hematology 119 (2), 388-398, 2012 | 227 | 2012 |
Thomas A MilneUniversity of Oxford, Weatherall Institute of Molecular MedicineVerified email at imm.ox.ac.uk
