|Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer|
CG Willett, Y Boucher, E Di Tomaso, DG Duda, LL Munn, RT Tong, ...
Nature medicine 10 (2), 145, 2004
|Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases|
F Winkler, SV Kozin, RT Tong, SS Chae, MF Booth, I Garkavtsev, L Xu, ...
Cancer cell 6 (6), 553-563, 2004
|Lymphatic metastasis in the absence of functional intratumor lymphatics|
TP Padera, A Kadambi, E di Tomaso, CM Carreira, EB Brown, Y Boucher, ...
Science 296 (5574), 1883-1886, 2002
|Normalization of the vasculature for treatment of cancer and other diseases|
S Goel, DG Duda, L Xu, LL Munn, Y Boucher, D Fukumura, RK Jain
Physiological reviews 91 (3), 1071-1121, 2011
|Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood|
YS Chang, E di Tomaso, DM McDonald, R Jones, RK Jain, LL Munn
Proceedings of the National Academy of Sciences 97 (26), 14608-14613, 2000
|Dissecting tumour pathophysiology using intravital microscopy|
RK Jain, LL Munn, D Fukumura
Nature Reviews Cancer 2 (4), 266, 2002
|Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging|
BJ Vakoc, RM Lanning, JA Tyrrell, TP Padera, LA Bartlett, ...
Nature medicine 15 (10), 1219, 2009
|Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model|
RK Jain, RT Tong, LL Munn
Cancer research 67 (6), 2729-2735, 2007
|During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.|
RJ Melder, GC Koenig, BP Witwer, N Safabakhsh, LL Munn, RK Jain
Nature medicine 2 (9), 992-997, 1996
|Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal …|
CG Willett, Y Boucher, DG Duda, E Di Tomaso, LL Munn, RT Tong, ...
Journal of Clinical Oncology 23 (31), 8136-8139, 2005
|Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy|
Y Huang, J Yuan, E Righi, WS Kamoun, M Ancukiewicz, J Nezivar, ...
Proceedings of the National Academy of Sciences 109 (43), 17561-17566, 2012
|Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors|
T Stylianopoulos, JD Martin, VP Chauhan, SR Jain, B Diop-Frimpong, ...
Proceedings of the National Academy of Sciences 109 (38), 15101-15108, 2012
|Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre‐clinical models|
DAI Fukumura, DG Duda, LL Munn, RK Jain
Microcirculation 17 (3), 206-225, 2010
|Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors|
RB Campbell, D Fukumura, EB Brown, LM Mazzola, Y Izumi, RK Jain, ...
Cancer research 62 (23), 6831-6836, 2002
|Fluid forces control endothelial sprouting|
JW Song, LL Munn
Proceedings of the National Academy of Sciences 108 (37), 15342-15347, 2011
|Mechanical compression drives cancer cells toward invasive phenotype|
MT Janet, G Cheng, JA Tyrrell, SA Wilcox-Adelman, Y Boucher, RK Jain, ...
Proceedings of the National Academy of Sciences 109 (3), 911-916, 2012
|Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells|
G Cheng, J Tse, RK Jain, LL Munn
PLoS one 4 (2), e4632, 2009
|Modeling the flow of dense suspensions of deformable particles in three dimensions|
MM Dupin, I Halliday, CM Care, L Alboul, LL Munn
Physical Review E 75 (6), 066707, 2007
|Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis|
S Patan, LL Munn, RK Jain
Microvascular research 51 (2), 260-272, 1996
|Edema control by cediranib, a vascular endothelial growth factor receptor–targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice|
WS Kamoun, CD Ley, CT Farrar, AM Duyverman, J Lahdenranta, ...
Journal of clinical oncology 27 (15), 2542, 2009