High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer A Datta, H Kim, L McGee, AE Johnson, S Talwar, J Marugan, N Southall, ... Scientific reports 8 (1), 8161, 2018 | 244 | 2018 |
Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells A Datta, H Kim, M Lal, L McGee, A Johnson, AA Moustafa, JC Jones, ... Cancer letters 408, 73-81, 2017 | 183 | 2017 |
Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma … MI Davis, R Pragani, JT Fox, M Shen, K Parmar, EF Gaudiano, L Liu, ... Journal of Biological Chemistry 291 (47), 24628-24640, 2016 | 125 | 2016 |
A high-throughput screening model of the tumor microenvironment for ovarian cancer cell growth M Lal-Nag, L McGee, R Guha, E Lengyel, HA Kenny, M Ferrer SLAS DISCOVERY: Advancing Life Sciences R&D 22 (5), 494-506, 2017 | 29 | 2017 |
Exploring drug dosing regimens in vitro using real-time 3D spheroid tumor growth assays M Lal-Nag, L McGee, SA Titus, K Brimacombe, S Michael, G Sittampalam, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (5), 537-546, 2017 | 14 | 2017 |
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs JL Grit, LE McGee, EA Tovar, CJ Essenburg, E Wolfrum, I Beddows, ... Oncogene, 1-20, 2024 | | 2024 |
YAP Signaling Promotes Resistance to MEK Inhibition in NF1-Related MPNSTs LE McGee Van Andel Research Institute, 2023 | | 2023 |
Abstract A018: YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs L McGee, C Essenburg, L Turner, A Hirbe, A Dey, J Zbieg, C Graveel, ... Clinical Cancer Research 28 (18_Supplement), A018-A018, 2022 | | 2022 |
Abstract PO-115: Defining mechanisms of resistance in NF1-related malignant peripheral nerve sheath tumors L McGee, J Grit, C Essenburg, C Graveel, M Steensma Cancer Research 80 (21_Supplement), PO-115-PO-115, 2020 | | 2020 |