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Timothy J Opperman
Timothy J Opperman
Senior Principal Scientist, Microbiotix, inc.
Verified email at microbiotix.com
Title
Cited by
Cited by
Year
Recent advances toward a molecular mechanism of efflux pump inhibition
TJ Opperman, ST Nguyen
Frontiers in microbiology 6, 140720, 2015
2832015
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
H Sjuts, AV Vargiu, SM Kwasny, ST Nguyen, HS Kim, X Ding, AR Ornik, ...
Proceedings of the National Academy of Sciences 113 (13), 3509-3514, 2016
2032016
A model for a umuDC-dependent prokaryotic DNA damage checkpoint
T Opperman, S Murli, BT Smith, GC Walker
Proceedings of the National Academy of Sciences 96 (16), 9218-9223, 1999
2031999
Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli
TJ Opperman, SM Kwasny, HS Kim, ST Nguyen, C Houseweart, ...
Antimicrobial agents and chemotherapy 58 (2), 722-733, 2014
2012014
Static biofilm cultures of Gram‐positive pathogens grown in a microtiter format used for anti‐biofilm drug discovery
SM Kwasny, TJ Opperman
Current protocols in pharmacology 50 (1), 13A. 8.1-13A. 8.23, 2010
1712010
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors
AV Vargiu, P Ruggerone, TJ Opperman, ST Nguyen, H Nikaido
Antimicrobial agents and chemotherapy 58 (10), 6224-6234, 2014
1632014
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 6,699,703, 2004
1552004
The Escherichia coli SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase
MD Sutton, T Opperman, GC Walker
Proceedings of the National Academy of Sciences 96 (22), 12373-12378, 1999
1241999
Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium
X Wang-Kan, JMA Blair, B Chirullo, J Betts, RM La Ragione, A Ivens, ...
MBio 8 (4), 10.1128/mbio. 00968-17, 2017
1132017
Phylogenetic analysis of sequences from diverse bacteria with homology to the Escherichia coli rho gene
T Opperman, JP Richardson
Journal of bacteriology 176 (16), 5033-5043, 1994
1011994
Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors
ST Nguyen, SM Kwasny, X Ding, SC Cardinale, CT McCarthy, HS Kim, ...
Bioorganic & medicinal chemistry 23 (9), 2024-2034, 2015
882015
Dimerization of the UmuD'protein in solution and its implications for regulation of SOS mutagenesis.
AE Ferentz, T Opperman, GC Walker, G Wagner
Nature structural biology 4 (12), 979-983, 1997
781997
Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation
TJ Opperman, SM Kwasny, JD Williams, AR Khan, NP Peet, DT Moir, ...
Antimicrobial agents and chemotherapy 53 (10), 4357-4367, 2009
722009
A Role for the umuDC Gene Products ofEscherichia coli in Increasing Resistance to DNA Damage in Stationary Phase by Inhibiting the Transition to Exponential …
S Murli, T Opperman, BT Smith, GC Walker
Journal of bacteriology 182 (4), 1127-1135, 2000
642000
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 7,378,514, 2008
632008
Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, C Houseweart
US Patent App. 11/524,787, 2007
632007
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 7,893,230, 2011
612011
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 7,893,230, 2011
612011
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 7,893,230, 2011
612011
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
L Doucette-Stamm, D Bush, Q Zeng, T Opperman, CE Houseweart
US Patent 7,893,230, 2011
612011
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